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海带多糖对受照小鼠脑血管损伤的保护作用 预览

Protective effect of Laminaria Japonica Polysaccharides on vessel in cerebral cortex
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摘要 为观察海带多糖对照射后脑皮层中小胶质细胞及微血管的影响,将120只雌性昆明小鼠随机分为对照组、单纯给药组、照射组及照射给药组,用60Coγ射线局部照射昆明小鼠脑部以建立放射性损伤的动物模型。分别于照射后1 d、7 d、14 d,对小鼠进行麻醉,取脑组织,通过免疫组织化学法测定小鼠脑皮层中血管CollagenⅣ蛋白及小胶质细胞Iba-Ⅰ蛋白的表达情况。结果表明,海带多糖可在有效抑制脑皮层中小胶质细胞激活的同时减少皮层微血管的丢失,从而进一步减轻小鼠的放射性脑损伤,有望成为一种安全有效的放射防护剂。 In order to observe the effect of Laminaria Japonica Polysaccharides ( LJP) on microglia and vessel in cerebral cortex after radiation , 120 female Kunming mice were randomly divided into four groups: control group, LJP group , radiation group and LJP + radiation group. The model of radiation-induced brain injury of mice was established by using 60^Coγ ray. The mice in the radiation and LJP + radiation groups were injected intraperitoneally with LJP at the dose of 100 mg/kg body weight everyday, while those in the control and LJP groups received solvent only. At 1 day, 7 day and 14 day after localized irradiation, brain tissues were collected for immunohistochemistry. Results showed that Laminaria japonica polysaccharides can effectively inhibit microglia activation and increase microvessel density in the cerebral cortex after irradiation. Laminaria japonica polysaccharides may be expected to become a safe and effective radiation protect agent.
作者 柴溶 张思琴 刘文其 徐杨 韦力 陈晨 符桢琳 CHAI Rong;ZHANG Siqi;LIU Wenqi;XU Yang;WEI Li;CHEN Chen;FU Zhenlin(College of Stomatology,Guangxi Medical University,Nanning 530021;Department of Radiology,The Second Affiliated of Guangxi Medical University,Nanning 530021;Department of Human Anatomy,Guangxi Medical University,Nanning 530021;Guangxi Key Laboratory of Regenerative Medicine,Nanning 530021)
出处 《辐射防护》 CAS CSCD 北大核心 2019年第3期249-253,共5页 Radiation Protection
基金 国家自然科学基金项目(81460479) 广西自然科学基金项目(2018JJA140600) 广西教育厅基金(ZD2014031)。
关键词 海带多糖 微血管密度 小胶质细胞 放射性脑损伤 Laminaria Japonica Polysaccharides microvessel density microliga radiation-induced brain injury
作者简介 柴溶(1994-),女,2015年7月毕业于山西医科大学口腔医学专业,现为广西医科大学口腔基础医学专业硕士研究生。E-mail:1710835755@qq.com;通讯作者:韦力。E-mail:759649859@qq.com.
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