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孕妇与新生儿脐血及对应儿童的乙型肝炎病毒标志物的对比分析 预览

Comparative Analysis of HBV Markers in Pregnant Women and Newborn Umbilical Cord Blood and Corresponding Children
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摘要 目的:探讨孕妇、新生儿和对应儿童的乙型肝炎病毒标志物的对比关系。方法:回顾性分析2016年1月~2019年1月某院妇产科收治的孕妇、新生儿和对应儿童60例,利用自动酶免仪和乙型肝炎病毒检测试剂盒(HBV)进行乙型肝炎病毒标志物对比分析。结果:HBV标志物的常见9种组合中,HBsAg阳性模式对应的垂直传播率为46.15%;孕妇的HBsAg阳性率为43.33%,新生儿脐带血为38.3%,对应儿童为20%,三者呈现HBsAg阳性率递减趋势(P<0.05);孕妇HBeAg阳性率为51.7%,新生儿脐带血为38.3%,对应儿童为25%,三者呈现HBeAg阳性率递减趋势,并存在显著差异(P<0.05)。结论:孕前乙型肝炎免疫球蛋白干预、新生儿和对应儿童的抗病毒治疗,以及乙型肝炎防治宣传,可以有效阻断母婴垂直传播。 Objective:To explore the comparative relationship of hepatitis B virus markers in pregnant women,newborns and corresponding children.Methods:Retrospective analysis of 60 cases of pregnant women,newborns and corresponding children admitted to the department of gynaecology and obstetrics of a hospital from January 2016 to January 2019,and the hepatitis B virus markers were compared and analyzed by automatic enzyme immunoassay and detection kit(HBV).Results:Among the 9 common combinations of HBV markers,the corresponding vertical transmission rate of HBsAg positive pattern was 46.15%.The positive rate of HBsAg was 43.33%for pregnant women,38.3%for neonatal cord blood,and 20%for corresponding children.There was a decreasing trend of HBsAg positive rate among the three groups(P<0.05).The vertical transmission rate of HBeAg was 51.7%in pregnant,38.3%in neonatal cord blood,and 25%in corresponding children.The positive rate of HBeAg showed a decreasing trend among the three groups,with a significant difference(P<0.05).Conclusion:Pre-pregnancy hepatitis b immunoglobulin intervention,antiviral therapy for neonates and corresponding children,and hepatitis B prevention publicity can effectively block the vertical transmission from mother to child.
作者 张淑仪 黄素然 Zhang Shuyi(Department of Obstetrics and Gynecology, Dongguan Guancheng Hospital, Dongguan 523000)
出处 《数理医药学杂志》 2019年第7期1025-1026,共2页 Journal of Mathematical Medicine
关键词 孕妇 新生儿 脐带血 乙型肝炎标志物 pregnant newborn cord blood HBV markers
作者简介 通讯作者:黄素然.
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