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我院522例抗菌药物不良反应报告及相关因素分析 预览

Analysis of 522 cases of antibiotics-induced adverse drug reaction reports and related factors in our hospital
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摘要 目的研究我院抗菌药物不良反应(ADR)发生的一般规律及特点,为临床合理安全用药提供参考依据。方法收集我院2013年1月~2017年12月上报的522份ADR报告,按照患者基本情况、给药途径、药物种类、临床表现、反应分级及转归情况进行回顾性分析。结果522例报告中发生ADR的患者中女性略多于男性,其中≤10岁的患者最多(30.46%);静脉滴注是引起ADR的最主要给药途径(97.70%);药品以头孢菌素类占比最高(41.18%);单品种以注射用左氧氟沙星(13.03%)所致的ADR最多;以皮肤及其附件损害最为常见(62.64%)。结论临床应进一步重视和加强抗菌药物ADR的监测工作,加强临床合理用药,确保患者用药安全。 Objective To investigate the characteristics and regularity of adverse drug reaction(ADR)induced by antibiotics in our hospital and provide reference for clinical rational drug use.Methods Totally 522 ADR reports were collected from our hospital from Jan 2013 to Dec 2017.Retrospective analysis was performed according to the patient′s basic information,route of administration,drug categories,clinical manifestations,reaction grading and regression.Results Among the 522 cases of ADR reports,the number of females was slightly higher than that of males;Younger than or equal to 10 years old of children were in the majority(30.46%);Most of ADR(97.70%)were related to intravenous infusion.The highest proportion was cephalosporins(41.18%).Levofloxacin occupied the top,accounting for 13.03%.The major organs involved in ADR were skin and accessories(62.64%).Conclusion The clinical should strengthen the monitoring of ADR induced by antimicrobial drugs,strengthen rational clinical application and ensure the patient medication safety.
作者 吴雨亭 冷静 WU Yuting;LENG Jing(Nanjing General Hospital of the Chinese People′s Liberation Army,Nanjing 210002,China)
出处 《西北药学杂志》 CAS 2019年第4期560-563,共4页 Northwest Pharmaceutical Journal
关键词 药物不良反应 抗菌药物 回顾性分析 adverse drug reaction(ADR) antimicrobial drugs retrospective analysis
作者简介 吴雨亭,女,药师;通信作者:冷静,男,主管药师.
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