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广西北部湾放线菌的分离筛选及活性产物的鉴定 预览

Isolation and screening of actinomycetes to produce antibiotic metabolites from Beibu Gulf nearby Guangxi
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摘要 为从广西北部湾的泥样和植物中分离海洋放线菌,筛选具有抑菌活性的菌株,分离活性化合物。研究采用普通稀释法分离菌株,对发酵产物进行抑菌活性测试,利用活性追踪分离活性化合物,并通过波谱方法确定化合物结构。结果表明从6个海泥样品和3个植物样品中共分离73株放线菌,筛选得到具有抑香蕉枯萎病和金黄色葡萄球菌活性的菌株7株,并从其中的1株链霉菌 Streptomyces sp.MDCW-126的次级代谢产物中分离鉴定了星形孢菌素。从广西北部湾分离的药用活性菌株资源具有开发和深入研究价值。 To isolate marine actinomycetes from Beibu Gulf nearby Guangxi soil and plants,and to screen antibiotic actinomycete strains,and to isolate active compounds.The isolation of actinomycetes was performed by normal methods,the screening of active fermentation products was preceded by antibacterial assays,the isolation of compounds were performed by bioassay-guided method,the structure of compound was elucidated through the spectroscopic analysis.The results showed that 73 actinomycetes strains were isolated from Beibu Gulf nearby Guangxi soil and plants,7 of which showed antimicrobial activities against Fusarium oxysporum f.sp. cubense , Staphylococcus aureus .And staurosporin was identified from the secondary metabolites of Streptomyces sp.MDCW-126.Actinomycetes from Beibu Gulf nearby Guangxi are potential resources for active strains and need further study.
作者 王聪 王坤 姜明国 谭学才 雷福厚 杜方凯 邱子言 孙坤来 WANG Cong;WANG Kun;JIANG Ming-guo;TAN Xue-cai;LEI Fu-hou;DU Fang-kai;QIU Zi-yan;SUN Kun-lai(Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Key Laboratory of Guangxi Collegesand Universities for Food Safety and Pharmaceutical Analytical Chemistry,School of Chemistry andChemical Engineering,Guangxi University for Nationalities;Guangxi Colleges and Universities Key Laboratory of Utilization of Microbial and Botanical Resources,School of Marine Sciences and Biotechnology,Guangxi University for Nationalities,Nanning 530006 ,China;Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products,School of Food and Pharmacy,Zhejiang Ocean University,Zhoushan 316022 ,China)
出处 《天然产物研究与开发》 CAS CSCD 北大核心 2019年第7期1170-1176,共7页 Natural Product Research and Development
基金 广西民族大学青年基金(2018MDQN003) 2018年广西高校中青年教师基础能力提升项目(2018KY0177) 广西科技基地和人才专项(桂科AD18126005) 广西创新驱动发展重大专项子课题(桂科AA17204087--21) 广西自然科学基金联合资助培育项目(2018GXNSFAA 294044).
关键词 广西北部湾 放线菌 抑菌活性 星形孢菌素 Beibu Gulf nearby Guangxi actinomycetes antimicrobial activity staurosporin
作者简介 通信作者:王聪,Tel:86-018776156656;E-mail:wangcong@gxun.edu.cn,wangcong123206@163.com.
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