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海洋真菌Arthrinium sp.UJNMF0008代谢产物的研究 预览

Secondary metabolites of marine fungus Arthrinium sp.UJNMF0008
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摘要 为丰富海洋真菌的化学多样性,发现海洋真菌活性代谢产物,对海洋沉积物来源真菌Arthriniumsp.UJNMF0008的化学成分及其生物活性进行研究,采用硅胶柱色谱、凝胶柱色谱、反向柱色谱和高效液相色谱等方法从海洋沉积物来源真菌Arthriniumsp.UJNMF0008的发酵提取物中分离到5个化合物,通过核磁共振、质谱等方法,结合文献对照,鉴定了化合物的结构分别为arthoneF(1)、arthoneG(2)、sydoxanthoneC(3)、(3R,4R)-cis-4-hydroxymellein(4)和2-(2′S-hydroxypropyl)-5-methyl-7-hydroxychromone(5),其中化合物1和2是新化合物,化合物3首次从该属真菌中分离到。活性测试显示,化合物1~5在50μmoL/L的测试浓度下均没有表现出明显的抗氧自由基活性、抗菌活性以及NO释放抑制活性。 To enrich the chemical diversity of marine fungi and explore their active metabolites,the secondary metabolites of marine-derived fungus Arthrinium sp.UJNMF0008 were investigated and their biological activities were evaluated.Five compounds were yielded from the fermentation extract of marine-sediment derived fungus Arthrinium sp.UJNMF0008 based on silica gel,Sephadex LH-20,ODS and HPLC methods,including arthone F ( 1),arthone G (2),sydoxanthone C (3 ),( 3R,4R )- cis -4-hydroxymellein ( 4 ) and 2-(2′ S -hydroxypropyl)-5-methyl-7-hydroxychromone ( 5 ).The structures of them were elucidated by the analysis of NMR data,MS and comparison with literatures.Compounds 1 and 2 were new compounds,while compound 3 was obtained from genus Arthrinium for the first time.However,no compounds indicated obvious bioactivity in our antimicrobial,antiradical and lipopolysaccharide-induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells.
作者 曾红 王荫荫 翟慧娟 贺菲 鲍洁 ZENG Hong;WANG Yin-yin;ZHAI Hui-juan;HE Fei;BAO Jie(Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization ofBiological Resources in Tarim Basin,Tarim University,Alar 843300 ,China;School of Biological Science and Technology,University of Jinan,Jinan 250022 ,China)
出处 《天然产物研究与开发》 CAS CSCD 北大核心 2019年第7期1211-1215,1191共6页 Natural Product Research and Development
基金 新疆生产建设兵团塔里木盆地生物资源保护利用重点实验室开放课题基金(BRYB1501) 山东省高校科研计划(J18KA255) 国家自然科学基金(41506148).
关键词 海洋真菌 Arthriniumsp. 次级代谢产物 聚酮 marine fungi Arthrinium sp. secondary metabolites polyketone
作者简介 通信作者:鲍洁,E-mail:bio_baoj@ujn.edu.cn.
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