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真菌Chaetomium sp.的次级代谢产物研究 预览

Study on the secondary metabolites of the fungus Chaetomium sp.
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摘要 目的对海洋毛壳属真菌Chaetomium sp.的次级代谢产物进行研究。方法 运用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、HPLC等现代色谱方法对Chaetomium sp.的发酵产物进行分离纯化,利用现代波谱技术结合文献报道进行结构鉴定。结果共分离得到4个十元环内酯化合物,botryolides A、botryolides B、botryolides D和decarestrictine I,1个倍半萜类化合物trichothecolone。结论本研究是对海洋真菌Chaetomium sp.次级代谢产物的首次报道,5种化合物均为首次从该种真菌中分离得到。 Objective To investigate the secondary metabolites of the marine fungi Chaetomium sp..Methods The EtOAc extract of Chaetomium sp.fermentation was purified by repeated column chromatography on silica gel,Sephadex LH-20,and high-performance liquid chromatography.The isolated compounds were structurally elucidated by spectroscopic analysis and by comparison with literatures previously reported.Results Four nonanolides including botryolides A ,B ,D ,decarestrictine I ,together with one sesquiterpene trichothecolone were isolated and structurally elucidated. Conclusion 5 Compounds were reported for the first time from the marine fungi Chaetomium sp.
作者 孟慧 许勇 MENG Hui;XU Yong(No.905 hospital of PLA Navy,Shanghai 200052,China)
出处 《药学实践杂志》 CAS 2019年第4期314-317,共4页 The Journal of Pharmaceutical Practice
基金 国家自然科学基金(81573342).
关键词 海洋真菌 毛壳属 十元环内酯 倍半萜 细胞毒活性 marine fungi Chaetomium sp. nonanolide sesquiterpene cytotoxicity
作者简介 孟慧,主任药师. 研究方向:药效物质基础;通讯作者:许勇,副主任药师.研究方向:药效物质基础. Email:xyong95@hotmail.com.
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