Objective To explore the effect of Jiao long Capsule and its main components on ulcerative colitis (UC) in mice. Method The model of ulcerative colitis was established by 2.5% DSS, and was randomly divided into 8 groups. At the same time, each treatment group was given the corresponding therapeutic drugs. The model group and the normal group were administrated with normal saline for 7 days. Activity index and colonic mucosal injury index score, serum NO and TNF-α levels and SP and VIP content in colon tissue were measured. Results Jiao long Capsule and its main components including gentiopicroside and loganic acid, can significantly improve the DAI and CMDI scores of UC mice, and dramatically reduce the serum NO and TNF-α levels in UC mice, and decrease the SP and VIP content in colon tissues. Conclusion Jiao long Capsule has a significant therapeutic effect on ulcerative colitis, and its functional ingredients are gentiopicroside and mazonic acid.
Guizhou Medical Journal
Jiao long Capsule