以吐温80为乳化剂,采用超声乳化法制备了杜仲籽油纳米乳液,研究了超声功率、超声时间、杜仲籽油体积分数、乳化剂质量浓度对纳米乳液平均粒径及Zeta电位绝对值的影响,通过响应面法优化了制备条件并对杜仲籽油纳米乳液的稳定性进行初步评价。结果表明:超声乳化法制备杜仲籽油纳米乳液的最佳工艺参数为超声时间5 min、超声功率432. 47 W、杜仲籽油体积分数7. 62%、乳化剂质量浓度0. 12 g/mL,在该条件下杜仲籽油纳米乳液的平均粒径为(121. 5±1. 43)nm,Zeta电位绝对值为(28. 6±0. 35) mV。当贮藏时间短于20 d且温度低于25℃时,制备的杜仲籽油纳米乳液的Zeta电位绝对值保持在30~20 mV之间,平均粒径处于100~150 nm,表明采用超声乳化法制备的杜仲籽油纳米乳液具有较好的贮藏稳定性。
The Eucommia seed oil nanoemulsion was prepared by ultrasonic emulsification with Tween 80 as emulsifier. The effects of ultrasonic power,ultrasonic time,volume fraction of Eucommia seed oil and mass concentration of emulsifier on the average particle size of the nanoemulsion were studied. The preparation conditions of Eucommia seed oil nanoemulsion were optimized by response surface methodology and the stability was preliminarily evaluated. The results showed that the optimal conditions for preparing Eucommia seed oil nanoemulsion by ultrasonic emulsification were obtained as follows: ultrasonic time5 min,ultrasonic power 432. 47 W,volume fraction of Eucommia seed oil 7. 62% and mass concentration of emulsifier 0. 12 g/mL. Under these conditions,the average particle size of Eucommia seed oil nanoemulsion was (121. 5 ± 1. 43) nm,and the absolute value of the Zeta potential was (28. 6 ± 0. 35)mV. When the Eucommia seed oil nanoemulsion was stored for less than 20 d and below 25 ℃,the absolute value of the Zeta potential of Eucommia seed oil nanoemulsion was 30-20 mV,and the average particle size was 100-150 nm,indicating that the Eucommia seed oil nanoemulsion prepared by ultrasonic emulsification had good storage stability.
China Oils and Fats
Eucommia seed oil