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超声引导聚桂醇泡沫硬化剂治疗对大隐静脉曲张患者外周血CEC、ET-1及NO值的影响 预览

Influence of ultrasound-guided lauromacrogol foam sclerotherapy on peripheral blood levels of CEC,ET-1 and NO in patients with saphenous vein varicosis
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摘要 目的:探讨超声引导聚桂醇泡沫硬化剂治疗对大隐静脉曲张患者外周血内皮细胞计数(CEC)、内皮素(ET)-1及一氧化氮(NO)水平的影响。方法:我院大隐静脉曲张患者90例,随机分为聚桂醇组(n=45,采用超声引导聚桂醇泡沫硬化剂进行治疗)和常规治疗组(n=45,采用常规剥脱术进行治疗)。比较两组手术前后患者外周血CEC、ET-1及NO等临床相关指标变化,评价其临床疗效及并发症发生情况。结果:与常规治疗组比较,聚桂醇组术中时间[(81.79±16.88)min比(40.55±10.19)min]和住院时间[(3.94±1.36)d比(2.17±1.31)d]均显著缩短,住院费用[(7640.15±1025.11)元比(3998.89±910.67)元]显著减少( P 均=0.001);术后与常规治疗组比较,聚桂醇组总并发症发生率(17.78%比4.44%)显著下降,病情Ⅰ级比例(6.67%比25.00%)显著增加,Ⅳ级比例(17.78%比4.44%)显著下降,外周CEC[(5562.48±1194.73)个/L比(4655.87±1209.88)个/L]、ET-1[(70.32±10.30) ng/L比(62.95±13.78) ng/L]水平均显著降低,NO[(1.27±0.42)μmol/L比(1.59±0.51)μmol/L]水平显著升高( P <0.05或<0.01)。结论:对大隐静脉曲张患者给予超声引导聚桂醇泡沫硬化剂治疗可显著提高疗效,改善血管内皮功能,且并发症少。 Objective: To explore influence of ultrasound-guided lauromacrogol foam sclerotherapy on peripheral blood levels of counting of endothelial cells (CEC),endothelin (ET)-1 and nitric oxide (NO) in patients with saphenous vein varicosis. Methods: A total of 90 patients with saphenous vein varicosis were randomly and equally divided into lauromacrogol group (received ultrasound-guided lauromacrogol foam sclerotherapy) and routine treatment group (received routine stripping). Peripheral blood levels of CEC,ET-1 and NO were observed and compared between two groups before and after surgery,and therapeutic effect and incidence of complications were evaluated. Results: Compared with routine treatment group,there were significant reductions in surgery time [(81.79±16.88)min vs.(40.55±10.19)min],hospitalization time [(3.94±1.36)d vs.(2.17±1.31)d] and hospitalization fee [(7640.15±1025.11) RMB vs.(3998.89±910.67)RMB] in lauromacrogol group, P =0.001 all. Compared with routine treatment group after surgery,there were significant reductions in incidence rate of total complications (17.78% vs. 4.44%),percentage of patient's condition class IV (17.78% vs. 4.44%),peripheral blood levels of CEC[(5562.48±1194.73)/L vs.(4655.87±1209.88)/L] and ET-1[(70.32±10.30) ng/L vs.(62.95±13.78) ng/L],and significant rise in percentage of patient’s condition class I (6.67% vs. 25.00%) and peripheral blood NO level [(1.27±0.42)μmol/L vs.(1.59±0.51)μmol/L] in lauromacrogol group, P <0.05 or <0.01. Conclusion: Ultrasound- guided lauromacrogol foam sclerotherapy can significantly increase therapeutic effect,improve vascular endothelial function in patients with saphenous vein varicosis. And its complications are few.
作者 单绍银 袁鹏 岳天华 吴式 吴锦丹 黄献琛 SHAN Shao-yin;YUAN Peng;YUE Tian-hua;WU Shi;WU Jin-dan;HUANG Xian-chen(Department of Interventional and Vascular Surgery,Jianhu County People′s Hospital of Jiangsu Province,Yancheng,Jiangsu,224700,China)
出处 《心血管康复医学杂志》 CAS 2019年第4期486-490,共5页 Chinese Journal of Cardiovascular Rehabilitation Medicine
基金 南京市医学科技发展项目(YKK12082).
关键词 静脉曲张 内皮 血管 治疗 Varicose veins Endothelium,vascular Therapy
作者简介 通讯作者:黄献琛,E-mail:Huangxc1981@163.com.
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