Objective:To analyze the relationship between serum tumor markers in patients with primary liver cancer and the expression of apoptosis-regulating genes in tumor tissues.Methods:From August 2017 to August 2018 were 50 cases of patients with primary liver cancer (research group) and have a medical examination during the same period of 50 cases of healthy volunteers (control group) as the research object, the detection of two groups of serum tumor markers GP73, TK1 and DKK1 expression level, analysis of apoptosis regulating gene expression in tumor tissues.Results:The serum levels of GP73, TK1 and DKK1 were higher in the study group, and the difference between the two groups was statistically significant (P<0.05). The expression levels of apoptosis inhibiting genes such as Livin, Plk1 and Xiap in liver cancer tissues were significantly higher than those in normal adjacent tissues (P<0.05), while the expression levels of pro-apoptotic genes such as caspase-3, caspase-8 and MTS1 in liver cancer tissues were significantly lower than those in normal adjacent tissues (P<0.05). The expression levels of serum gp-73, TK1 and DKK1 were positively correlated with the expression levels of apoptotic inhibiting genes in liver tissues, and negatively correlated with the expression levels of pro-apoptotic genes.Conclusion:The expression levels of tumor markers TK1, gp-73 and DKK1 in serum of patients with primary liver cancer are abnormally increased, and positively correlated with the expression of apoptotic inhibiting genes in liver tissues, and negatively correlated with the expression of pro-apoptotic genes.
Heilongjiang Medicine and Pharmacy
primary liver cancer
serum tumor markers
apoptotic regulatory genes