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多西环素联合克林霉素治疗女性生殖道支原体感染的临床疗效和安全性的效果观察

Clinical Efficacy and Safety of Doxycycline Combined with Clindamycin in the Treatment of Female Genital Mycoplasma Infection
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摘要 目的探讨生殖道支原体感染的女性患者应用克林霉素+多西环素治疗的临床效果及其安全性。方法方便择取该院于2018年1月—2019年1月期间收治的生殖道支原体感染女性患者92例,根据患者的入院先后顺序将其划分为单一组和联合组,每组46例,单一组患者接受单一多西环素治疗,联合组患者在多西环素治疗的基础上加用克林霉素,对比两组患者的临床治疗效果(痊愈、缓解、无效)及不良反应(恶心、静脉炎、皮疹、头痛、腹泻、腹痛、呕吐)。结果联合组中痊愈25例、缓解19例、无效2例,治疗有效率为95.7%(44/46),单一组中痊愈15例、缓解22例、无效9例,治疗有效率为80.4%(37/46),联合组优于单一组,组间数据差异有统计学意义(χ^2=5.060,P=0.024<0.05);单一组中恶心1例、静脉炎1例、皮疹1例、头痛1例、腹泻0例、腹痛2例、呕吐1例,联合组中恶心0例、静脉炎1例、皮疹2例、头痛2例、腹泻1例、腹痛1例、呕吐1例,联合组不良反应率17.4%(8/46),单一组为15.2%(7/46),组间数据差异无统计学意义(χ^2=0.080,P=0.778>0.05)。结论针对生殖道支原体感染的女性患者应用克林霉素+多西环素治疗,相较于单一地使用多西环素治疗,能够有效改善临床治疗效果,且患者不良反应较少,安全性较高,具有重要的临床意义,值得推广和应用。 Objective To investigate the clinical efficacy and safety of clindamycin+doxycycline in female patients with genital mycoplasma infection.Methods Convenient select a total of 92 female patients with genital mycoplasma infection who were admitted to our hospital from January 2018 to January 2019 were enrolled.The patients were divided into single group and combined group according to the order of admission,with 46 cases in each group.A single group of patients received a single treatment with doxycycline,and the combination group received clindamycin on the basis of doxycycline therapy,comparing the clinical effects(healing,remission,ineffectiveness)and adverse reactions of the two groups of patients(nausea,phlebitis,rash,headache,diarrhea,abdominal pain,vomiting).Results In the combined group,25 cases were cured,19 cases were relieved,and 2 cases were ineffective.The effective rate was 95.7%(44/46).In the single group,15 cases were cured,22 cases were relieved,and 9 cases were ineffective.The effective rate was 80.4%(37/46),the combination group was better than the single group,and there was statistical difference between the groups(χ^2=5.060,P=0.024<0.05);In the single group,1 case of nausea 1 case of phlebitis,1 case of rash,1 case of headache 0 cases of diarrhea,2 cases of abdominal pain,1 case of vomiting,and in combined group 0 cases of nausea,1 case of phlebitis,2 cases of rash,2 cases of headache,1 case of diarrhea,1 case of abdominal pain,1 case of vomiting,adverse reaction rate of combined group 17.4%(8/46),15.2%(7/46)in the single group,there was no statistical difference between the groups(χ^2=0.080,P=0.778>0.05).Conclusion The treatment of clindamycin+doxycycline in women with genital mycoplasma infection can effectively improve the clinical treatment effect compared with the single use of doxycycline treatment,and the patient has fewer adverse reactions and higher safety,which has important clinical significance,and is worthy of promotion and application.
作者 孙金莉 陈曦 SUN Jin-li;CHEN Xi(Reproductive Center of the First Affiliated Hospital of Xiamen University,Xiamen,Fujian Province,361003 China)
出处 《中外医疗》 2019年第26期4-7,共4页 China & Foreign Medical Treatment
基金 福建省卫生计生青年科研课题项目(2017-2-100) 福建省自然科学基金计划项目(2018J01376,2019J01574)。
关键词 多西环素 克林霉素 女性患者 生殖道支原体感染 疗效观察 Doxycycline Clindamycin Female patients Genital mycoplasma infection Efficacy observation
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