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复方甘草酸单铵S致高血压1例 预览

Hypertension induced by intravenous infusion of compound ammonium glycyrrhetate S injection
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摘要 1例68岁女性糖尿病患者,因肝脓肿入院。给予哌拉西林他唑巴坦(4.5 g,q 12 h,ivgtt)抗感染;因肝功能异常(天门冬氨酸氨基转移酶118 U·L^-1、丙氨酸氨基转移酶65 U·L^-1、直接胆红素20.8μmol∙L^-1、总胆红素30.0μmol∙L^-1)给予复方甘草酸单铵S注射液(20 mL,qd,ivgtt)保肝降酶;给予盐酸二甲双胍片、西格列汀片口服和精蛋白锌重组赖脯胰岛素混合注射液25R皮下注射控制血糖。用药第5天,患者静脉滴注复方甘草酸单铵S后出现面部发红、头痛、心慌等症状,测血压186/110 mm Hg。立即停用复方甘草酸单铵S注射液,给予硝苯地平片30 mg口服降压,30 min后临床症状缓解。 A 68-year-old female patient with diabetes was hospitalized mainly because of hepatapostema.Then the patient was treated with piperacillin sodium and tazobactam sodium(4.5 g,q 12 h,ivgtt)for anti-infection.Because of abnormal liver function,compound ammonium glycyrrhetate S injection(20 mL,qd)was given for protecting liver and lowering transaminase(Aspartate aminotransferase 118 U·L^-1,Alanine aminotransferase 65 U·L^-1,Direct bilirubin 20.8μmol·L^-1,Total bilirubin 30.0μmol·L-1).Metformin hydrochloride tablets,sitagliptin tablets and mixed protamine zinc recombinant human insulin lispro injection(25R)were used to control blood glucose.On day 5,the patient showed facial redness,headache and palpitation,whose blood pressure was 186/110 mm Hg after use of compound ammonium glycyrrhetate S injection,and then this preparation was stopped,and nifedipine tablets 30 mg was orally received.About 30 minutes later,the patient's symptoms subsided completely.
作者 王金明 申昌龙 董德强 魏静 周雪峰 夏修远 曹明雪 WANG Jin-ming;SHEN Chang-long;DONG De-qiang;WEI Jing;ZHOU Xue-feng;XIA Xiu-yuan;CAO Ming-xue(Department of Pharmacy,Municipal Hospital Affiliated to Medical College of Taizhou University,Taizhou 318000,China;Yanbian Hospital of Traditional TCM Hospital Yanji,Yanji 133000,China;The People's Hospital of Dehui City,Dehui 130300,China;Department of Pharmacy,302 Hospital of PLA,Beijing 100039,China)
出处 《中国药物应用与监测》 CAS 2019年第4期251-253,共3页 Chinese Journal of Drug Application and Monitoring
基金 浙江省药学会医院药学专项科研项目(2017ZYY28) 椒江区科技计划项目(122083) 台州市立医院青年项目(TZMH-17-7)
关键词 复方甘草酸单铵S 高血压 药品不良反应 Compound ammonium glycyrrhetate S injection Hypertension Adverse drug reaction
作者简介 王金明,男,副主任药师,研究方向:临床药学。E-mail:wjm6688@163.com
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