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rt-PA溶栓的配套护理干预措施对急性脑卒中患者日常生活能力、神经功能及炎症因子水平的影响 预览

Supportive intervention measures for rt-PA thrombolysis in patients with acute cerebral palsy and its effect on ADL score of patients
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摘要 目的:探讨重组组织型纤溶酶原激活剂(rt-PA)溶栓的配套护理干预措施对急性脑卒中患者日常生活能力(ADL)、神经功能及血清炎症因子水平的影响。方法:选取2016年1月至2018年1月首都医科大学附属北京友谊医院收治的急性脑卒中患者88例作为研究对象,随机分为对照组与研究组,每组44例。两组均行rt-PA溶栓治疗,对照组采用常规护理干预,研究组在对照组基础上进行综合康复护理干预。分别于干预前及干预1 d、7 d、14 d后,比较两组ADL评分、美国国立卫生研究院卒中量表(NIHSS)评分及血清炎症因子水平。结果:干预后各时间点,研究组ADL评分显著高于对照组,NIHSS评分显著低于对照组(P<0. 05);干预14 d后,研究组患者血清C反应蛋白(CRP)、肿瘤坏死因子(TNF)-α、白介素(IL)-6水平均低于对照组(均P<0. 05)。结论:对急性脑卒中患者进行rt-PA溶栓及配套护理干预措施,可显著提高患者ADL评分,改善神经功能缺损状况,减轻炎症反应。 Objective: To investigate the effect of thrombolytic therapy with rt-PA on daily life ability(ADL),nerve function and serum inflammatory factor levels in patients with acute cerebral infarction. Methods: 88 patients with acute cerebral infarction in our hospital from January 2016 to January 2018 were selected,and randomly divided into a control group and a research group,with 44 cases in each group. Patients in both groups were treated with rt-PA thrombolysis. The patients in the control group received routine nursing care,and those in the observation group were treated as the control group with addition of comprehensive rehabilitation nursing care. The ADL score,NIHSS score and serum levels of inflammatory factors were compared between the two groups. Results: At each time point after intervention,the ADL score of the study group was higher than that of the control group,and the NIHSS score was significantly lower(P<0. 05). The levels of serum C-reactive protein(CRP),tumor necrosis factor(TNF)-α and interleukin(IL)-6 in the study group were lower than those in the control group after 14 days of intervention(P<0. 05). Conclusion: rt-PA thrombolysis and supporting intervention measures could significantly elevate ADL score,improve neurological function,and attenuate inflammatory response in patients with acute cerebral infarction.
作者 李亚男 王倩 Li Yanan;Wang Qian(Emergency Department,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China;Cardiothoracic Surgery,Beijing Anzhen Hospital Affiliated to Capital Medical University,Beijing 100029,China)
出处 《广西医科大学学报》 CAS 2019年第10期1692-1695,共4页 Journal of Guangxi Medical University
基金 北京市医院管理局重点医学专业发展计划课题资助项目(No.ZYLX201802)。
关键词 急性脑卒中 RT-PA溶栓 配套干预措施 ADL评分 acute cerebral infarction rt-PA thrombolysis supporting intervention measures ADL score
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