富氢水抗炎活性及分子机制研究进展

Anti-inflammatory activity and molecular mechanisms of hydrogen-rich water:recent progress

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摘要炎症与氧化应激是多种疾病病理过程的2个方面,它们互相促进,造成疾病的恶性循环。富氢水是富含氢气的水,研究表明,富氢水可选择性清除过量羟自由基,有效减轻机体氧化损伤,在不同病理状态下减轻组织的炎性损伤。近年来研究发现,富氢水可以改善类风湿关节炎、结肠炎、肝炎、胰腺炎等多种炎性状态,其抗炎作用的发挥与减轻氧化应激损伤和参与p38-MAPK、NF-κB等信号转导通路的调控有关。本文就富氢水的抗炎活性及其作用机制作一综述。 Inflammation and oxidative stress are two aspects of the pathology of many diseases,and they also promote each other,causing a vicious cycle of the disease.Hydrogen-rich water is the water rich in hydrogen.Studies have proved that hydrogen-rich water can selectively reduce hydroxyl radicals and ameliorate oxidative and inflammatory injuries to organs and tissues under different pathological conditions.In recent years,it has been found that hydrogen-rich water can improve the inflammatory conditions of rheumatoid arthritis,colitis,hepatitis,pancreatitis,etc.Its anti-inflammatory effects are related to the amelioration of oxidative stress and regulation of the signal transduction pathways such as p38-mitogen-activated protein kinase(p38-MAPK)and nuclear factorκB(NF-κB).In the present review,the anti-inflammatory activity of hydrogen-rich water and its molecular mechanisms are summarized and discussed.

作者姜婧张瑶蒋芮李雅婷宋立华 JIANG Jing;ZHANG Yao;JIANG Rui;LI Ya-ting;SONG Li-hua(Department of Food Science&Technology,Shanghai Jiao Tong University School of Agriculture and Biology,Shanghai 200240,China)

机构地区上海交通大学农业与生物学院食品科学与工程系

出处《第二军医大学学报》 CAS CSCD 北大核心 2020年第7期798-802,共5页 Academic Journal of Second Military Medical University

基金上海市科技兴农项目(2019-02-08-00-08-F01154)。

关键词氢富氢水炎性疾病抗炎活性抗氧化活性信号通路 hydrogen hydrogen-rich water inflammatory diseases anti-inflammatory activity antioxidant activity signaling pathway

分类号 R364.5 [医药卫生—病理学]

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