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甘桔冰梅片联合头孢他美酯治疗急性咽炎的临床研究

Clinical study on Ganju Binmei Tablets combined with cefetamet pivoxil in treatment of acute pharyngitis
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摘要 目的探讨甘桔冰梅片联合头孢他美酯治疗急性咽炎的临床疗效。方法选取2016年2月—2018年2月在重庆市巴南区人民医院进行治疗的312例急性咽炎,根据入院号的奇偶数分为对照组和治疗组,每组各161例。对照组口服盐酸头孢他美酯片,0.5 g/次,2次/d。治疗组在对照组患者治疗基础上口服甘桔冰梅片,0.4 g/次,3次/d。两组均治疗7 d进行效果比较。观察两组的临床疗效,比较两组治疗前后症状积分和血清学指标的变化情况。结果治疗后,对照组和治疗组的总有效率分别是84.47%、98.14%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组咽痛评分、咽部黏膜充血评分、咽部干燥评分、咽部灼热感评分、咳嗽评分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组这些症状积分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组这些血清炎性因子水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论甘桔冰梅片联合头孢他美酯治疗急性咽炎具有较好的临床疗效,可有效改善患者临床症状,降低机体炎症因子水平,具有一定的临床推广应用价值。 Objective To investigate the clinical efficacy of Ganju Binmei Tablets combined with cefetamet pivoxil in treatment of acute pharyngitis.Methods 312 Patients with acute pharyngitis in People’s Hospital of Banan District in Chongqing from February2016 to February 2018 were divided into control(161 cases)and treatment(161 cases)groups according to the odd and even number of admission numbers.Patients in the control group were po administered with Cefetamet Pivoxil Hydrochloride Tablets,0.5 g/time,twice daily.Patients in the treatment group were po administered with Ganju Binmei Tablets on the basis of the control group,0.4 g/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical efficacy was evaluated,and the changes of symptom scores and serological indicators in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control and treatment groups were 84.47%and 98.14%,respectively,and there were differences between two groups(P<0.05).After treatment,pharynx pain score,pharynx mucosa hyperemia score,pharynx dryness score,pharynx burning sensation score and cough score were all significantly decreased in the two groups,and there were differences in the same group(P<0.05).After treatment,hs-CRP,IL-1β,IL-6,and TNF-αin two groups were significantly decreased,and there were differences in the same group(P<0.05).After treatment,these serological indicators in the treatment group were lower than those in the control group,and there were differences between two groups(P<0.05).Conclusion Ganju Binmei Tablets combined with cefetamet pivoxil has significant effect in treatment of acute pharyngitis,and can effectively improve the clinical symptoms and reduce the inflammatory factors in the body,which has a certain clinical application value.
作者 毕丹 蒋睿果 BI Dan;JIANG Rui-guo(Otolaryngology Head and Neck Surgery,People’s Hospital of Banan District in Chongqing,Chongqing 401320,China)
出处 《现代药物与临床》 CAS 2019年第4期1129-1132,共4页 Drugs & Clinic
关键词 甘桔冰梅片 盐酸头孢他美酯片 急性咽炎 症状积分 超敏C反应蛋白 白细胞介素-1Β 白细胞介素-6 Ganju Binmei Tablets Cefetamet Pivoxil Hydrochloride Tablets acute pharyngitis symptom score hs-CRP IL-1β IL-6
作者简介 毕丹,主治医师,研究方向是耳鼻喉头颈科疾病的诊疗。E-mail:bidan2003@163.com;通讯作者:蒋睿果,男,主治医师。E-mail:snipeapple@163.com
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