目的探究宫腔用交联透明质酸钠凝胶在宫腔粘连分离术后的应用效果。方法选取2018年1月—2019年1月于开封市妇产医院妇一科行宫腔粘连分离术患者122例,随机分为对照组和治疗组,每组各61例。对照组患者行常规宫腔粘连分离术,治疗组患者在常规宫腔粘连分离术后,借助医用宫腔导管注入3 mL宫腔用交联透明质酸钠凝胶,注入完成后嘱患者平躺30 min。观察两组的临床疗效,比较两组术后3个月月经恢复、美国生育协会(AFS)评分情况。结果治疗后,对照组和治疗组的总有效率分别是75.41%、90.16%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者月经复潮痛经情况少于对照组,复潮时间早于对照组,月经量异常情况少于对照组,两组比较差异具有统计学意义(P<0.05)。患者术后3个月的AFS评分中,治疗组宫腔粘连累及范围评分、月经模式评分和总分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论宫腔粘连分离术后适量注入宫腔用交联透明质酸钠凝胶疗效显著,可减轻患者复潮痛经情况,使月经恢复正常,降低宫腔粘连程度,具有一定的临床推广应用价值。
Objective To explore the clinical efficacy of hyaluronic acid in treatment of intrauterine adhesion.Methods Patients(122 cases)with intrauterine adhesion in Kaifeng Obstetrics and Gynecology Hospital from January 2018 to January 2019 were randomly divided into control(61 cases)and treatment(61 cases)groups.Patients in the control group received conventional intrauterine adhesion and separation.Patients in the treatment group were injected with 3 mL of Crosslinked Sodium Hyaluronate Gel for uterine cavity with the help of medical intrauterine catheter after conventional intrauterine adhesion and separation.After the injection,patients were instructed to lie flat for 30 min.After treatment,the clinical efficacy was evaluated,and the menstrual recovery and AFS scores in two groups were compared 3 months after operation.Results After treatment,the clinical efficacy in the control and treatment groups were 75.41%and 90.16%,respectively,and there were differences between two groups(P<0.05).After treatment,the cases of menstrual dysmenorrhea in the treatment group were less than that in the control group,and the retidal time was earlier than that in the control group,and the cases of abnormal menstrual volume were less than that in the control group,and there were differences between two groups(P<0.05).Three months after surgery,intrauterine adhesion involvement scale scores,menstrual pattern score and total score of AFS scores in the treatment group were lower than those in the control group,and there were differences between two groups(P<0.05).Conclusion After intrauterine adhesion separation,proper injection of intrauterine cavity with Crosslinked Sodium Hyaluronate Gel for uterine cavity has a significant effect,and can reduce patients’dysmenorrhea,and can make menstruation return to normal,also can reduce the degree of uterine cavity adhesion,which has a certain clinical application value.
Drugs & Clinic
Crosslinked Sodium Hyaluronate Gel for uterine cavity
intrauterine adhesion and separation