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新型湿性敷料联合内服托毒生肌散治疗慢性复杂创面临床研究

The Clinical Research into Chronic Complex wound Treated with New-Type Wet Dressing Combined with Tuodu Shengji Powder
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摘要 目的:观察新型湿性敷料联合内服托毒生肌散治疗慢性复杂创面的临床疗效。方法:选取2016年1月至2018年1月在本院创面治疗中心治疗的慢性复杂创面患者185例,随机分为中西医结合组93例和西医组92例。西医组单独使用新型敷料按时换药,中西医结合组在使用新型敷料换药的同时给予托毒生肌散加减内服。两组均以1个月为1个疗程。治疗前后检测创面渗出液中转化生长因子-β1(transforming growth factor-β1,TGF-β1)和白细胞介素-1β(interleukin-1β,IL-1β)的水平,并比较两组患者治疗效果。结果:中西医结合组有效率95.24%明显高于西医组82.26%,差异有统计学意义(P<0.05);中西医结合组出现上皮化时间、创面愈合时间均比西医组短,差异有统计学意义(P<0.05);两组治疗后与治疗前比较,TGF-β1水平明显升高,IL-1β水平明显降低,差异有统计学意义(P<0.05),且组间比较差异有统计学意义(P<0.05)。结论:新型湿性敷料联合内服托毒生肌散治疗慢性复杂创面,能缩短创面愈合时间,改善调控伤口愈合的相关生长因子。 Objective:To observe the clinical curative effect of new-type wet dressing combined with Tuodu Shengji Powder(TDSJP).Methods:One hundred and eighty-five patients with chronic complex wounds treated in Wound Treatment Center in our hospital from January 2016 to January 2018 were randomly divided into the integrated traditional Chinese with 93 cases and the Western medicine group with 92 cases.The western medicine group used the new-type dressing to change dressings on time,while the integrated traditional Chinese and Western medicine group used the new-type dressing to change dressings combined with Modified TDSJP for oral administration.The ones in both groups were treated for one month as a course.The levels of transforming growth factor-β1(TGF-beta 1) and interleukin-1(IL-1β1) in wound exudates were measured before and after the treatment,and the therapeutic effects were compared between the two groups.Results:The effective rate of the integrated traditional Chinese and Western medicine group was 95.24%,which was higher than that of the Western medicine group(82.26%,P<0.05).The time of epithelialization and wound healing in the integrated traditional Chinese and Western medicine group was shorter than that in the Western medicine group(P<0.05).After the treatment,the levels of TGF-β and IL-1β in the two groups were significantly higher than those before the treatment(P<0.05).The differences were statistically significant(P<0.05).After the treatment,the levels of TGF-β1 and IL-1β in the two groups were significantly higher than those before the treatment(P<0.05),and there were significant differences between the two groups(P<0.05).Conclusion:New-type wet dressing combined with TDSJP has a remarkable clinical curative effect on chronic complex wound,can shorten the time of wound healing and improve the growth factors related to wound healing.
作者 王瑞淑 左庆选 李新丽 齐永奇 WANG Rui-shu;ZUO Qing-xuan;LI Xin-li;QI Yong-qi(Puyang People's Hospital,Puyang,Henan,China,457000;North China University of Water Resources and Hydropower,Zhengzhou,Henan,China,450000)
出处 《河南中医》 2019年第4期587-590,共4页 Henan Traditional Chinese Medicine
基金 河南省高等学校重点科研项目(15A413015).
关键词 慢性复杂创面 新型敷料 托毒生肌散 转化生长因子-β1 白细胞介素-1β chronic complex wound new-type dressing Tuodu Shengji Powder(TDSJP) transforming growth factor-β1(TGF-β1) interleukin 1(IL-1β)
作者简介 王瑞淑(1968-),女,河南濮阳人,主管护师。
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