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“神农33号”对多器官功能障碍综合征大鼠细胞因子的影响 预览 被引量:88

Effects of Shennong 33 on cytokines in rats with multiple organ dysfunction syndrome
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摘要 目的研究中药"神农33号"注射液对血瘀证多脏器功能障碍综合征(MODS)大鼠细胞因子的影响.方法利用Wister大鼠制备血瘀证MODS动物模型,将大鼠随机分为4组:对照组,模型组,低剂量中药组,高剂量中药组.检测各组血清内毒素及TNF-α、IL-1β、IL-6水平,探讨"神农33号"的作用及细胞因子之间的关系.结果模型组TNF-α水平与IL-1β、IL-6呈正相关(P<0.01),其血清TNF-α、IL-1β、IL-6明显高于正常对照组(P<0.01);与模型组相比,中药组尤其高剂量中药组的血清TNF-α、IL-6水平明显降低(P<0.01).结论中药"神农33号"注射液对MODS大鼠的血清TNF-α、IL-6有明显的下调作用,在一定程度上缓解了炎症,有保护组织器官及防治MODS的作用. Objective To determine the effect of Shenong 33 on cytokines in rats with MODS.Methods Rats with MODS model were randomly divided into 4 groups:normal group,model group,high dose group and low dose group.Serum levels of TNF α,IL 1β,IL 6 and LPS were measured.The effect of Shennong 33 and its relationship with the cytokines were eveluated.Results Serum levels of TNF α,IL 1β and IL 6 in the model group increased significantly(P<0 01).However,compared to the model group,serum levels of TNF α and IL 6 in the high dose group decreased significantly(P<0 01).Conclusion Shennong 33 down regulates serum levels of TNF α and IL 6 in rats with MODS. [
作者 曹书华 高红梅 王永强 常文秀 CAO Shuhua,GAO Hongmei,WANG Yongqiang,et al.Department of ICU,The First Central Hospital of Tianjin,Tianjin,300192
出处 《中华急诊医学杂志》 CAS 2003年第2期 94-96,共3页 Chinese Journal of Emergency Medicine
基金 天津市科委科研项目
关键词 多器官功能障碍综合征 “神农33号”注射液 中医药治疗 细胞因子 TNF-Α IL-6 动物实验 Multiple organ dysfunction syndrome Cytokine Shennong 33
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