期刊文献+

皮肌炎病情反复风险因素的分析

Analysis of risk factors for relapse of dermatomyositis
收藏 分享 导出
摘要 目的:探讨皮肌炎(DM)患者治疗缓解后出现病情反复的风险因素及总结抗Ro-52抗体阳性患者的临床特点。方法:收集2014年1月—2017年12月贵州医科大学附属医院皮肤科住院治疗的77例DM患者的流行病学、实验室及辅助检查结果、治疗及随访情况等,并采用SPSS18.0软件进行统计分析。联合Kaplan-Meier检验和比例风险回归模型(Cox)分析影响患者病情反复的因素。结果:抗Ro-52抗体阳性和并发恶性肿瘤是DM患者病情平稳后出现反复的独立风险因素。抗Ro-52抗体阳性的DM患者并发间质性肺炎(ILD)、并发心脏损害、并发恶性肿瘤、病情反复及死亡率均高于抗Ro-52抗体阴性者。结论:抗Ro-52抗体阳性和并发恶性肿瘤是DM患者病情稳定后反复的风险因素,且抗Ro-52阳性提示并发ILD、并发心脏损害、并发恶性肿瘤及高死亡率。 Objective: To summarize the risk factors for relapse of dermatomyositis(DM) after remission and the clinical features of the patients with anti Ro-52 antibody positive. Methods: Data of epidemiology, auxiliary examination results, treat ment and follow up were collected from patients with DM in the Department of Dermatology, Affiliated Hospital of Guizhou Med ical University from January 2014 to December 2017. SPSS18.0 was used to analyze the data. Kaplan-meier test and Cox regression analysis were used to assess the risk factors for relapse of DM after remission. Results: Anti-Ro-52 antibody positive and cancer were independent risk factors for relapse. Patients with anti-Ro-52 antibody positive displayed higher rates of interstitial lung disease(ILD), heart damage, cancer, relapse and deaths than those with anti-Ro-52 antibody negative. Conclusions: Both anti-Ro-52 antibody positive and cancer are independent risk factors for relapse of DM. The anti-Ro-52 antibody positive indicates that the patients could be complicated by ILD, heart damage and cancer along with higher mortality.
作者 欧阳叶艮 张伟 余德厚 陆洪光 OUYANG Ye-gen;ZHANG Wei;YU De-hou;LU Hong-guang(Department of Graduate School,Guizhou Medical University,Guiyang 550001,China)
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2019年第2期78-81,共4页 Journal of Clinical Dermatology
关键词 皮肌炎 病情反复 抗Ro-52抗体 dermatomyositis relapse anti-Ro-52 antibodies
作者简介 通讯作者:陆洪光,E-mail:hongguanglu@hotmail.com
  • 相关文献

参考文献5

二级参考文献40

  • 1周亚欧,左晓霞,游运辉,罗卉.皮肌炎/多发性肌炎肺间质病变的临床及相关因素分析[J].中华风湿病学杂志,2005,9(5):318-319. 被引量:24
  • 2陈瑞林,陶怡.多发性肌炎/皮肌炎134例临床分析[J].广州医学院学报,2006,34(2):29-33. 被引量:6
  • 3谭艳红,刘冬舟,肖学吕,冯小欣,孙保东,洪小平,黄勤,蔡文虹.多发性肌炎和皮肌炎72例临床分析[J].实用医学杂志,2007,23(13):2044-2045. 被引量:6
  • 4Alspaugh M,Maddison P.Resolution of the identity of certain antigen-antibody system in systemic lupus erthematosus and Sj(o)gren's syndrome:an interlaboratory collaboration[J].Arthritis Rheum,1979,22(7):796-798. 被引量:1
  • 5Ottosson L.Molecular characterization of the Ro52 autoantigen and its disease related epitopes[M].Stockholm:Repro Print AB,2005. 被引量:1
  • 6Ottosson L,Henning J,Espinosa A,et al.Structural,functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sj(o)gren's syndrome[J].Mol Immunol,2006,43(6):588-598. 被引量:1
  • 7Seto M H,Liu H L,Zajchowski D A,et al.Protein fold analysis of the B30.2-like domain[J].Proteins,1999,35(2):235-249. 被引量:1
  • 8Yang Y,Eversole T,Lee D J,et al.Protein-protein interactions between native Ro52 and immunoglobulin G heavy chain[J].Scand J Immunol,1999,49(6):620-628. 被引量:1
  • 9Peek R,Pruijn G J,van der Kemp A J,et al.Subcellular distribution of Ro ribonucleoprotein complexes and their constituens[J].J Cell Sci,1993,106(pt 3):929-935. 被引量:1
  • 10Pourmand N,Blange I,Ringertz N,et al.Intracellular localisation of the Ro52 auto-antigen in HeLa cells visualised with green fouorescent protein chimeras[J].Autoimmunity,1998,28(4):225-233. 被引量:1

共引文献9

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈