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异功膏摩对幼鼠生长发育及相关激素影响的探索性研究

Study of Effect of Yigong Ointment Massage on Growth and Development of Infant Rats and Related Hormone Levels
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摘要 目的:观察异功膏摩对幼鼠生长发育及生长激素、胃动素、胃泌素的影响,为探索早产儿的有效干预方法提供前期研究基础。方法:幼鼠出生后第4天(P4),对各笼内幼鼠进行编号并随机分组,各笼内实验组和对照组数量对半,实验组与对照组总计均为10只。实验组予异功膏摩,对照组予凡士林膏摩。每日定时检测体质量并记录睁眼时间;第22天(P22)处死,对生长激素、胃动素、胃泌素进行检测。结果:两组幼鼠实验结束时,体质量及睁眼时间比较差异具有统计学意义(P<0.05),实验组优于对照组;两组幼鼠生长激素比较差异无统计学意义(P> 0.05);胃动素比较实验组高于对照组,差异具有统计学意义(P<0.05);胃泌素比较实验组虽低于对照组,但差异无统计学意义(P> 0.05)。结论:异功膏摩能够促进幼鼠的生长发育,可作为生长发育问题的干预手段之一。生长发育除受中枢调控外,还可能与消化系统即中医后天之本脾胃相关。 Objective:To observe the effect of Yigong ointment massage on the growth and development,growth hormone,motilin and gastrin of the infant rat,and to provide a research basis of the effective intervention for the premature birth. Methods:Infant rats were randomly divided into the experimental group and control group 4 days after birth,with 10 rats in each group. The experimental group received Yigong ointment massage,while the control group received vaseline ointment massage. The body weight was measured and the time of eyes-open was recorded every day. Rats were executed at the age of 22 days and growth hormone,motilin and gastrin were tested. Results:On the body weight and eyes-open time,the experimental group was better than the control group,with statistically significant difference(P<0.05). On the level of growth hormone,there was no difference between the two groups(P> 0.05).On the level of motilin,the experimental group was significantly higher than the control group,with statistically significant difference(P<0.05). On the level of gastrin,the experimental group was lower than the control group,but without statistically significant difference(P> 0.05). Conclusion:Yigong ointment massage can improve the growth and development of infant rat,and it may be an effective intervention for growth and development. In addition to the central nerve system,the digestive system,the foundation of acquired constitution,may also play a role in the regulation of growth and development.
作者 张星贺 宋咏丽 王厚融 施英华 邰先桃 井夫杰 ZHANG Xinghe;SONG Yongli;WANG Hourong;SHI Yinghua;TAI Xiantao;JING Fujie(College of Acupuncture-Moxibustion and Tuina,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;School of Basic Medical Sciences,Kunming Medical University,Kunming 650500,Kunming China;College of Acupuncture,Moxibustion,Tuina and Rehabilitation,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China)
出处 《山东中医杂志》 2019年第1期72-76,共5页 Shandong Journal of Traditional Chinese Medicine
基金 山东省科技攻关计划资助项目(编号:2013G0021807) 云南省科技厅-云南中医学院应用基础研究联合专项重点项目(编号:2017FF17-006).
关键词 异功膏摩 生长发育 生长激素 胃动素 胃泌素 Yigong ointment massage growth and development growth hormone motilin gastrin
作者简介 张星贺(1991-),男,河南平顶山人,2017年级博士研究生,主要从事推拿早期干预高危儿的基础及临床研究。邮箱:doczhangxh@163.com;通信作者:井夫杰(1970-),男,山东日照人,教授,博士研究生导师,主要从事推拿治疗儿科常见病的研究。邮箱:jingfujie@126.com。
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