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杞贞滋阴合剂治疗迟发性性腺功能减退症的临床评价

Clinical evaluation of Qizhen Ziyin Mixture in the treatment of late onset hypogonadism
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摘要 目的观察杞贞滋阴合剂治疗迟发性性腺功能减退症(肾阴亏虚型)的临床疗效。方法将152例迟发性性腺功能减退症(肾阴亏虚型)患者随机分为治疗组和对照组,每组76例。治疗组给予杞贞滋阴合剂治疗,对照组给予十一酸睾酮治疗,两组疗程均为8周,观察中医证候积分、迟发性性腺功能减退症症状调查表(SILOH)评分、血清总睾酮水平(TT)、体质量指数(BMI)变化情况。结果①治疗前后组内比较,两组腰膝酸软、神疲乏力、潮热盗汗、失眠健忘、性欲冷漠、勃起障碍积分差异均有统计学意义(P<0.05);组间治疗后比较,治疗组潮热盗汗积分低于对照组(P<0.05),对照组勃起障碍积分低于治疗组(P<0.05),其余各项积分差异无统计学意义(P>0.05)。②治疗前后组内比较,两组SILOH体能血管舒缩症状、精神心理症状及性功能症状积分差异均有统计学意义(P<0.05);组间治疗后比较,性功能症状积分差异有统计学意义(P<0.05),其余各项积分差异无统计学意义(P>0.05)。③治疗前后组内比较,两组睾酮水平差异均有统计学意义(P<0.05),体质量指数均无显著变化(P>0.05);组间治疗后比较,睾酮水平差异有统计学意义(P<0.05),体质量指数差异无统计学意义(P>0.05)。结论杞贞滋阴合剂在改善迟发性性腺功能减退症(肾阴亏虚型)患者临床症状方面,具有和激素替代疗法相似的效果。 Objective To observe the clinical efficacy of Qizhen Ziyin Mixture in the treatment of late onset hypogonadism with syndrome of kidney-yin deficiency.Methods 152 patients of late onset hypogonadism with syndrome of kidney-yin deficiency were randomly divided into the treatment group and control group,76 cases in each group. The treatment group was treated with Qizhen Ziyin Mixture,and the control group was treated with testosterone undecanoate,with a course of 8 weeks. The changes of TCM syndrome scores,symptomatic inventory for screening late onset hypogonadism( SILOH) scores,the serum level of total testosterone( TT) and body mass index( BMI) were observed. Results ①For the comparison of treatment before and after,the differences on the scores of soreness and weakness of waist and knees,spiritlessness and weakness,tidal fever and night sweating,insomnia and amnesia,asexuality and erectile dysfunction in both groups were statistically significant( P < 0. 05). For the comparison after treatment,the score of tidal fever and night sweating in the treatment group was lower than that in the control group( P < 0. 05),the score of erectile dysfunction in the control group was lower than that in the treatment group( P < 0. 05),and there were no statistically significant differences on the other scores between the two groups( P > 0. 05). ②For the comparison of treatment before and after,the differences on the SILOH scores of physical fitness,vasodilation and vasoconstriction symptoms,mental and psychological symptoms and sexual function symptoms in both groups were statistically significant( P < 0. 05). For the comparison after treatment,there was statistically significant difference on the score of sexual function symptoms between the two groups( P < 0. 05),and the differences on the other scores were not statistically significant between the two groups( P > 0. 05). ③For the comparison of treatment before and after,the difference on the testosterone level in both groups was statistically significant( P < 0. 05),th
作者 郁超 龚华 何晓锋 曹宏文 悉之骏 赵友康 曾荣财 陈磊 YU Chao;GONG Hua;HE Xiao-feng;CAO Hong-wen;XI Zhi-jun;ZHAO You-kang;ZENG Rong-cai;CHEN Lei;Department of Surgery,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Zhou Zhiheng’s Studio,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Department of Pharmacy,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
出处 《上海中医药杂志》 2017年第5期68-71,共4页 Shanghai Journal of Traditional Chinese Medicine
基金 上海市科委科技支撑项目(13401901702) 上海市卫计委综合医院中西医结合专项课题重点项目(ZHYYZXYJHZX-1-03)
关键词 迟发性性腺功能减退症 杞贞滋阴合剂 中医药疗法 替代疗法 late onset hypogonadism Qizhen Ziyin Mixture therapy of traditional Chinese medicine alternative therapy
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