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活血潜阳祛痰方干预肥胖高血压患者左室重构的临床观察 被引量:1

Clinical observation of effects of Huoxue Qianyang Qutan Recipe on left ventricular remodeling in obese patients with hypertension
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摘要 目的 观察活血潜阳祛痰方治疗肥胖高血压患者的临床疗效及其对左室重构的干预作用。方法 将90例伴左室重构的肥胖高血压患者随机分为治疗组及对照组,每组45例。对照组维持原西医治疗方案并进行健康宣教,治疗组在对照组治疗措施基础上加用活血潜阳祛痰方。两组疗程均为3个月,观察比较形体学指标、诊室内血压、动态血压、中医证候积分、糖脂代谢指标、心脏结构测定指标的变化情况。结果 (1)试验结束时两组完成试验病例共82例,其中治疗组40例、脱落5例,对照组42例、脱落3例,总脱落率约为8.9%。(2)组间治疗后比较,体质量、腰围及BMI水平差异有统计学意义,治疗组对形体肥胖的改善明显优于对照组(P<0.05)。(3)组间治疗后比较,诊室内收缩压、舒张压差异有统计学意义,治疗组降压效果明显强于对照组(P<0.05)。(4)组间治疗后比较,24 h平均收缩压、夜间平均收缩压差异有统计学意义(P<0.05)。(5)组间治疗后比较,中医证候积分差异有统计学意义,治疗组中医证候积分明显低于对照组(P<0.05)。(6)组间治疗后比较,总胆固醇、三酰甘油、低密度脂蛋白、空腹胰岛素、胰岛素抵抗指数水平差异有统计学意义,治疗组明显低于对照组(P<0.05)。(7)组间治疗后比较,室间隔厚度、左心室心肌重量、左心室重量指数水平差异有统计学意义,治疗组较对照组明显下降(P<0.05)。结论 活血潜阳祛痰方治疗肥胖高血压患者,可明显改善患者肥胖状态及糖脂代谢,可在原有降压方案的基础上进一步改善血压,还可一定程度上改善患者的左室重构。 Objective To observe the clinical efficacy of Huoxue Qianyang Qutan Recipe in treating obese patients with hypertension and the intervention effects on left ventricular remodeling. Methods 90 obese patients with hypertension and left ventricular remodeling were randomly divided into the treatment group and control group,45 cases in each group. The control group was treated with the original therapy of western medicine and health education,and the treatment group was additionally treated with Huoxue Qianyang Qutan Recipe based on the treatment for the control group,with a course of 3 months. The indexes of body shape,blood pressure in consulting room,ambulatory blood pressure,TCM syndrome score,indicators of glucose and lipid metabolism and indexes of cardiac structure were observed and compared. Results(1)Until the end of trial,a total of 82 cases completed the whole trial,among 40 cases in the treatment group( 5 cases fell off) and42 cases in the control group( 3 cases fell off). The total expulsion rate was 8. 9%.(2)After treatment,there were statistically significant differences on the levels of body weight,waistline and body mass index( BMI) between the two groups,and the improvement on body obesity in the treatment group was significantly better than that in the control group( P < 0. 05).(3)After treatment,there were statistically significant differences on the systolic and diastolic blood pressure in consulting room between the two groups,and the hypotensive effects of the treatment group were more significant than those of the control group( P < 0. 05).(4)After treatment,there were statistically significant differences on the 24 h mean systolic pressure and night mean systolic pressure between the two groups( P < 0. 05).(5)After treatment,there was statistically significant difference on TCM syndrome score between the two groups,and the TCM syndrome score of the treatment group was obviously lower than that of the control group( P < 0. 05).(6) After treatment,there were statistically significant difference
作者 周训杰 姚磊 符德玉 桂明泰 芦波 李建华 韩亚楠 龙敏 舒婷 ZHOU Xun-jie;YAO Lei;FU De-yu;GUI Ming-tai;LU Bo;LI Jian-hua;HAN Ya-nan;LONG Min;SHU Ting;Department of Cardiology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine;
出处 《上海中医药杂志》 2017年第9期43-47,共5页 Shanghai Journal of Traditional Chinese Medicine
基金 上海市卫计委进一步加快中医药事业发展三年行动计划项目(ZY3-CCCX-3-3026) 上海市卫计委“治未病”预防保健项目体系建设项目政策和技术类子项目(ZY3-FWMS-1-1001-KYJS-11) 上海市教委高等学校博士学科点专项科研基金项目(20133107110011) 上海中医药大学预算内项目(2015YSN4)
关键词 原发性高血压 中心性肥胖 左室重构 糖脂代谢 活血潜阳祛痰方 essential hypertension central obesity left ventricular remodeling glucose and lipid metabolism Huoxue Qianyang Qutan Recipe
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