Objective: To investigate the correlation between serum lipoprotein related phospholipase A2(Lp-PLA2), high sensitive C reactive protein(hs-CRP), interleukin-27(IL-27) and matrix metalloproteinase-9(MMP-9) levels and Gensini score in elderly patients with coronary heart disease. Methods: A total of 142 patient with coronary heart disease, who were treated in Second Affiliated Hospital of Army Medical University from October 2015 to February 2018 were chosen as research subjects and were divided into unstable angina pectoris(UAP) group(n=54), stable angina pectoris(SAP) group(n=40) and acute myocardial infarction(AMI) group(n=48) according to different types of coronary heart disease;meanwhile, the patients were further divided into mild(n=47), moderate(n=51) and severe(n=44) according to the Gensini score. The levels of Lp-PLA2, hs-CRP, IL-27, MMP-9 and Gensini score were compared among different coronary heart disease types and severity, and the correlation between the above indexes levels and Gensini score was analyzed. Results: The levels of Lp-PLA2, hs-CRP, IL-27 and MMP-9 and Gensini score in AMI group were higher than those in UAP group and SAP group, and the UAP group was higher than the SAP group(P<0.05). The levels of Lp-PLA2, hs-CRP, IL-27 and MMP-9 and Gensini score in severe patients were higher than those in moderate and mild patients,and moderate patients were higher than mild patients(P <0.05). The results of Spearman correlation analysis showed that Lp-PLA2, hs-CRP, IL-27 and MMP-9 levels were positively correlated with Gensini score in the patients with coronary heart disease(P <0.05). Conclusion: The levels of Lp-PLA2,hs-CRP, IL-27 and MMP-9 in the elderly patients with coronary heart disease are positively correlated with Gensini score of coronary artery disease, which is helpful to assess the severity of coronary heart disease in elderly patients according in the clinical application.
Progress in Modern Biomedicine