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老年冠心病患者血清Lp-PLA2、hs-CRP、IL-27及MMP-9水平与Gensini积分的相关性研究

Patients with Coronary Heart Disease: Correlation Study between Serum Lp-PLA2, hs-CRP, IL-27 and MMP-9 Levels and Gensini Score Elderly
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摘要 目的:探讨老年冠心病患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)、高敏C反应蛋白(hs-CRP)、白细胞介素-27(IL-27)及基质金属蛋白酶-9(MMP-9)水平与Gensini积分的相关性。方法:选取2015年10月至2018年2月我院收治的冠心病患者142例为研究对象,将所有患者按照不同的冠心病类型分为不稳定型心绞痛(UAP)组54例、稳定型心绞痛(SAP)组40例和急性心肌梗死(AMI)组48例。同时根据患者Gensini积分将其分为轻度47例、中度51例和重度44例。比较不同冠心病类型、不同严重程度的Lp-PLA2、hs-CRP、IL-27、MMP-9水平及Gensini积分,并分析冠心病患者上述指标水平与Gensini积分的相关性。结果:AMI组患者Lp-PLA2、hs-CRP、IL-27、MMP-9水平及Gensini积分均高于UAP组和SAP组,且UAP组高于SAP组(P<0.05)。重度患者Lp-PLA2、hs-CRP、IL-27、MMP-9水平及Gensini积分均高于中度和轻度患者,且中度患者高于轻度患者(P<0.05)。经Spearman相关性分析结果显示,冠心病患者Lp-PLA2、hs-CRP、IL-27、MMP-9水平与Gensini积分均呈正相关(P<0.05)。结论:老年冠心病患者Lp-PLA2、hs-CRP、IL-27及MMP-9水平与患者冠状动脉病变Gensini积分均呈正相关。临床根据Lp-PLA2、hs-CRP、IL-27及MMP-9水平的变化,有助于评估老年冠心病患者的病情严重程度。 Objective: To investigate the correlation between serum lipoprotein related phospholipase A2(Lp-PLA2), high sensitive C reactive protein(hs-CRP), interleukin-27(IL-27) and matrix metalloproteinase-9(MMP-9) levels and Gensini score in elderly patients with coronary heart disease. Methods: A total of 142 patient with coronary heart disease, who were treated in Second Affiliated Hospital of Army Medical University from October 2015 to February 2018 were chosen as research subjects and were divided into unstable angina pectoris(UAP) group(n=54), stable angina pectoris(SAP) group(n=40) and acute myocardial infarction(AMI) group(n=48) according to different types of coronary heart disease;meanwhile, the patients were further divided into mild(n=47), moderate(n=51) and severe(n=44) according to the Gensini score. The levels of Lp-PLA2, hs-CRP, IL-27, MMP-9 and Gensini score were compared among different coronary heart disease types and severity, and the correlation between the above indexes levels and Gensini score was analyzed. Results: The levels of Lp-PLA2, hs-CRP, IL-27 and MMP-9 and Gensini score in AMI group were higher than those in UAP group and SAP group, and the UAP group was higher than the SAP group(P<0.05). The levels of Lp-PLA2, hs-CRP, IL-27 and MMP-9 and Gensini score in severe patients were higher than those in moderate and mild patients,and moderate patients were higher than mild patients(P <0.05). The results of Spearman correlation analysis showed that Lp-PLA2, hs-CRP, IL-27 and MMP-9 levels were positively correlated with Gensini score in the patients with coronary heart disease(P <0.05). Conclusion: The levels of Lp-PLA2,hs-CRP, IL-27 and MMP-9 in the elderly patients with coronary heart disease are positively correlated with Gensini score of coronary artery disease, which is helpful to assess the severity of coronary heart disease in elderly patients according in the clinical application.
作者 付静 熊秋璨 王霞 钟灵 乔巧 余洁 FU Jing;XIONG Qiu-can;WANG Xia;ZHONG Ling;QIAO Qiao;YU Jie(Department of Cardiology,The Second Affiliated Hospital of Army Medical University,Chongqing,400000,China)
出处 《现代生物医学进展》 CAS 2019年第1期137-140,共4页 Progress in Modern Biomedicine
基金 国家自然科学基金项目(81570418).
关键词 冠心病 老年 脂蛋白相关磷脂酶A2 高敏C反应蛋白 白细胞介素-27 基质金属蛋白酶-9 GENSINI积分 相关性 Coronary heart disease Elderly Lipoprotein related phospholipase A2 High sensitive C reactive protein Interleukin-27 Matrix metalloproteinase-9 Gensini score Correlation
作者简介 付静(1986-),女,本科,主治医师,从事冠心病方面的研究,E-mail:qasdei@163.com;通讯作者:余洁(1979-),女,博士,副教授,从事动脉粥样硬化血管损伤及冠心病治疗方面的研究,E-mail:grttyh@163.com
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