期刊文献+

联合用药治疗急性脊髓损伤的临床研究

Clinical Research of Combined Medication in Treatment of Acute Spinal Cord Injury
收藏 分享 导出
摘要 目的:分析单唾液酸四己糖神经节苷脂钠联合甲泼尼龙治疗急性脊髓损伤的疗效。方法:按照随机数字表法将2016年7月至2018年7月重庆医科大学附属永川医院收治的急性脊髓损伤患者84例分为对照组和观察组,每组42例。对照组给予甲泼尼龙治疗,观察组给予单唾液酸四己糖神经节苷脂钠联合甲泼尼龙。采用美国脊髓损伤协会(ASIA)评分标准评定两组患者运动功能和感觉功能,比较治疗效果和不良反应发生率。结果:两组治疗后(出院时)ASIA评分(运动、触觉、痛觉)均有明显提高,且观察组高于同期对照组,差异具有统计学意义(P <0.05)。观察组的总有效率为92.86%,明显高于对照组的69.05%,组间比较,差异具有统计学意义P <0.05);两组患者不良反应的发生率比较,差异均无统计学意义(P> 0.05)。结论:单唾液酸四己糖神经节苷脂钠联合甲泼尼龙治疗急性脊髓损伤具有较好的临床疗效,且安全性较高。 Objective To analyze the effect of monosialotetrahexosyl ganglioside sodium combined with methylprednisolone in treatment of acute spinal cord injury.Methods According to the random number table method,84 cases of patients with acute spinal cord injury admitted in Yongchuan hospital affiliated to Chongqing medical university from July 2016 to July 2018 were divided into control group and observation group,42 cases in each group.The control group were given methylprednisolone treatment,observation group were given monosialotetrahexosyl ganglioside sodium combined with methylprednisolone.The motor and sensory function of patients in the two groups was assessed by ASIA scoring criteria,and the treatment effect and adverse reaction rate was compared.Results After treatment(leave hospital),the scores of ASIA(motion,touch,pain)of the two groups was significantly improved,and the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The total effective rate of observation group was 92.86%(39/42),significantly higher than the control group 69.05%(29/42),the difference was statistically significant(P<0.05);The adverse reaction rate of two groups had no significant difference(P>0.05).Conclusion Monosialotetrahexosyl ganglioside sodium combined with methylprednisolone has better clinical efficacy in treatment of acute spinal cord injury,and high safety.
作者 朱凤臣 张铭华 蒋电明 ZHU Feng-chen;ZHANG Ming-hua;JIANG Dian-ming(Yongchuan Hospital Affiliated to Chongqing Medical University,Chongqing 402160;Department of orthopedics of Third Affiliated Hospital of Chongqing Medical University,Chongqing 401120)
出处 《深圳中西医结合杂志》 2019年第4期9-11,共3页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金 重庆医科大学附属永川医院引进人才项目资助课题(YJYJ20120004)。
关键词 单唾液酸四己糖神经节苷脂钠 甲泼尼龙 急性脊髓损伤 Monosialotetrahexosyl ganglioside sodium Methylprednisolone Acute spinal cord injury
作者简介 朱凤臣,男,主治医师,主要研究方向是脊柱及关节损伤;通信作者:蒋电明(E-mail:jdm571026@vip163.com,Tel:13983836636)。
  • 相关文献

参考文献7

二级参考文献76

共引文献230

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈