Objective To observe and evaluate the clinical nursing effect for LASIK surgery patient which accepted evidencebased care. Methods Inner Mongolia Medical University Hospital myopia laser treatment center, from January 2016 to June 2016,135 cases(270) LASIK surgery patients for the study were randomized divided into two groups. 65 patients(130) to study group which carry the implementation of evidence-based care, the other 70 cases(140) as the control group uses regular care to observe the compliance of patients, the degree of health knowledge and care satisfaction. Result The three values of study group are higher than the control group, the difference was statistically significantly(x~2=4.84, P=0.03; x~2=5.05, P=0.03; x~2=4.64, p=0.03). Conclusion Evidence-based care can improve the compliance, mastery of health knowledge, ensure safety of surgery and increase of care satisfaction which is worthy of popularity and application.