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幽门螺杆菌感染与动脉粥样硬化性脑梗死的相关性研究 预览

Correlation between Helicobacter Pylori Infection and Atherosclerotic Cerebral Infarction
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摘要 目的研究分析幽门螺杆菌感染(HP)在临床中与动脉粥样硬化性脑梗死之间的相关性。方法随机抽取在2017年1月至2018年7月到我院就诊的70例动脉粥样硬化性脑梗死患者,归为观察组;并选择同期入院的非急性脑梗死患者70例,归为对照组。对两组研究对象HP感染情况、颈动脉彩超、血脂等情况进行分析。结果观察组中有40例为HP阳性,所占比重为57.1%(40/70),30例为HP阴性,所占比重为42.9%(30/70)。对照组中有28例为HP阳性,所占比重为40.0%(28/70),42例为HP阴性,所占比重为60.0%(42/70)。比较两组研究对象HP阳性率情况,差异显著(χ~2=5.788,P=0.016)。同HP阴性组比较,HP阳性组TC、LDL-C、TG指标水平较高(P<0.05),而HDL-C指标水平较低(P<0.05),斑块不稳定率较高(P<0.05);HP阳性组ApoA1、ApoB、叶酸、维生素B12水平较HP阴性组明显更低(P<0.05),FIB、HCY水平较HP阴性组明显更高(P<0.05);HP感染严重程度与TC、LDL-C、TG、FIB、HCY等项目水平呈正相关(P<0.05),与HDL-C、ApoA1、ApoB、叶酸、维生素B12指标水平呈负相关(P<0.05)。结论在临床中,HP感染是动脉粥样硬化性脑梗死的主要危险因素,在脑卒中防控中不仅需要对传统的危险因素进行干预,还需要对HP感染进行干预。并以此为动脉粥样硬化性脑梗死的临床防控工作提供新的参考依据。 Objective To analyze the correlation between Helicobacter pylori infection(HP) and atherosclerotic cerebral infarction. Methods Seventy patients with atherosclerotic cerebral infarction who were admitted to our hospital from January 2017 to July 2018 were randomly selected and assigned to the observation group. Seventy patients with non-acute cerebral infarction admitted in the same period were selected as control group. The crowd was classified as a control group. The HP infection, carotid ultrasound and blood lipids were analyzed in the two groups. Results Of the observation group, 40 were HP positive, accounting for 57.1%(40/70), and 30 were HP negative, accounting for 42.9%(30/70). In the control group, 28 cases were positive for HP, accounting for 40.0%(28/70), and 42 cases were HP negative, accounting for 60.0%(42/70). The HP positive rate of the two groups was compared, and the difference was significant(χ~2=5.788, P=0.016). Compared with the HP-negative group, the HP-positive group had higher levels of TC, LDL-C, and TG(P<0.05), while the HDL-C index was lower(P<0.05), and the plaque instability rate was higher(P<0.05);ApoA1, ApoB and HCY levels in HP positive group were significantly lower than those in HP negative group(P<0.05), The levels of FIB and HCY were significantly higher than those of HP negative group(P<0.05);the severity of HP infection was related to TC, LDL-C, TG, FIB, HCY, etc. In the red font part of the abstract section, folic acid, vitamin B12 and HCY, the description of the correlation is reversed. The project level was positively correlated(P<0.05), with HDL-C, ApoA1, ApoB, folic acid, and vitamin B12 in the red font section of the abstract section, the description of the correlation between folic acid, vitamin B12, and HCY was reversed. The indicator level was negatively correlated(P<0.05). Conclusion In clinical practice, HP infection is the main risk factor of atherosclerotic cerebral infarction. In the prevention and control of stroke, not only the traditional risk factors should
作者 孙德刚 王志坤 张琳琳 邢占刚 王林 阮俊 于璐瑶 孙妍 白雪 SUN De-gang;WANG Zhi-kun;ZHANG Lin-lin;XING Zhan-gang;WANG Lin;RUAN Jun;YU Lu-yao;SUN Yan;BAI Xue(Heilongjiang Youyi Nongken Hongxinglong Administration Central Hospital,Shuangyashan,Heilongjiang,China)
出处 《世界最新医学信息文摘(电子版)》 2019年第5期1-2,44共3页 World Latest Medicine
基金 黑龙江省卫生计生委课题,课题编号:2016-451.
关键词 动脉粥样硬化 幽门螺杆菌感染 脑梗死 Atherosclerosis Helicobacter pylori infection Cerebral infarction
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