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幽门螺杆菌现症感染与慢性阻塞性肺病急性发作的相关性研究 预览

Study on the Relationship between Helicobacter Pylori Infection and Acute Attack of Chronic Obstructive Pulmonary Disease
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摘要 目的研究幽门螺杆菌(Hp)现症感染与慢性阻塞性肺病(COPD)急性加重发作是否相关。方法选取2015年8月至2017年5月期间杭州市余杭区第五人民医院门急诊及住院的符合纳入条件的86例患者作为研究对象,入选患者均进行13C呼气试验。然后根据COPD当时所处的时期分为两组,即稳定期、急性加重期;再根据13C呼气试验结果分出阳性组、阴性组;以上4组患者,每月通过电话随访及查询门急诊就诊记录或住院记录相结合,随访观察1年,详细记录这1年中COPD急性加重发作的次数;最后对收集的数据进行统计学处理,寻找Hp现症感染与COPD急性加重发作之间的相关性。结果急性加重期COPD(AECOPD)组患者共44例,其中Hp现症感染9例,现症感染率(即13C呼气试验阳性率)为20.5%,而稳定期COPD(COPD)组患者共42例,其中Hp现症感染20例,感染率为47.6%,两组比较差异有统计学意义,P<0.05;但是HP现症感染与COPD急性加重发作次数之间无相关性,P>0.05。结论 Hp菌现症感染与COPD患者急性加重发作无相关性。 Objective To study the effect of Helicobacter pylori(HP)infection on acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 86 patients were enrolled from those met COPD criteria and had ever admitted at the Fifth people’s Hospital of Yuhang District of Hangzhou during August 2015 to May 2017.13C breath test was performed in all patients.They were divided into two groups according to the conditions of patients at that time,Two groups werestable phase and acute exacerbation phase.Based on the results of 13C breath test,the patients were also divided into positive group and negative group,respectively.All patients were followed up for one year by telephone and read the medical record monthly.Which main included the onset times of acute exacerbation of COPD with in one year.Chi-square test was used during data analysis.Results There were 44 patients in acute exacerbation of COPD(AECOPD)group.Of them,9 patients were infected with Helicobacter pylori.The prevalence of Helicobacter pylori infection was 20.5%in patients with acute exacerbation of COPD in(AECOPD)group while 47.6%in patients with(COPD)in stable stage,and the positive rate of 13C breath test was 20.5%in patients with acute exacerbation of(COPD)while 47.6%in patients with stable(COPD).There was a significant difference between the two groups(P<0.05).However,there was no correlation between HP(Helicobacter pylori)infection and the frequency of acute exacerbation of COPD(P>0.05).Conclusion No correlation between Helicobacter pylori infection and acute exacerbation of COPD was found.
作者 何乐 王晓通 李维郑 刘明 周华娟 洪萍 钟小花 陈展 张忠南 叶亮 HE Le;WANG Xiao-tong;LI Wei-zheng;LIU Ming;ZHOU Hua-juan;HONG Ping;ZHONG Xiao-hua;CHEN Zhan;ZHANG Zhong-nan;YE Liang(Fifth people's Hospital of Yuhang District,Hangzhou City,Hangzhou Zhejiang)
出处 《世界最新医学信息文摘》 2019年第63期8-9,11共3页 World Latest Medicine Information
基金 浙江省杭州市余杭区卫生和计划生育局支持项目(2015012).
关键词 幽门螺杆菌现症感染 幽门螺杆菌感染阴性 13C尿素呼气试验 慢性阻塞性肺病急性加重 慢性阻塞性肺病稳定期 Helicobacter pylori infection Helicobacter pylori negative 13C breath test Acute exacerbation of chronic obstructive Pulmonary Disease Stable phase of chronic obstructive Pulmonary Disease
作者简介 何乐,女,汉族,毕业于兰州大学,研究方向慢性阻塞性肺病,杭州市余杭区第五人民医院急诊/重症监护科主任医师;通讯作者:何乐。
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