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锶元素在骨组织工程研究中的应用与进展 预览

Application and progress of strontium in bone tissue engineering
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摘要 背景:锶元素在骨组织工程中已得到广泛应用,能够促进成骨细胞分化、抑制破骨细胞的吸收。目的:综述锶元素在骨组织工程中的应用与研究进展。方法:应用计算机检索CNKI数据库、PubMed数据库及Elsevier数据库中收录的相关文献,中文检索词为'锶元素,锶,骨,骨缺损,骨修复,组织工程',英文检索词为'strontium,Sr,bone,bonedefects,bone repair,tissue engineering'。查阅1960年1月至2018年12月期间收录的锶元素在骨组织工程中应用的相关文章,包括综述、基础研究及临床研究,通过阅读文题和摘要进行初步筛选,排除与文章主题不相关的文献,根据纳入标准和排除标准,最终纳入48篇文献进行结果分析。结果与结论:锶元素作为骨组织重要的组成成分,在骨的发育和形成过程中扮演着重要角色。掺锶的骨替代材料已成为目前骨组织工程研究的重点和热点,大量研究证实,锶的掺入能够有效改善骨替代材料的力学性能,提高对成骨细胞的招募能力及分化能力,同时促进体内成骨和成血管能力。但目前的研究还存在一定的不足:不同研究使用的掺锶方法不同,所以研究结果不具有可比性;不同掺锶量所得出的研究结论不同;目前尚无一个比较公认的掺锶浓度可用来诱导成骨分化。 BACKGROUND: Strontium has been widely used in bone tissue engineering to promote osteoblast differentiation and inhibit osteoclast absorption.OBJECTIVE: To review the application and progress of strontium in bone tissue engineering.METHODS: A computer-based search of CNKI, PubMed, and Elsevier databases was performed for retrieving articles concerning the application of strontium in bone tissue engineering published from January 1960 to December 2018. The keywords were 'strontium, Sr, bone, bone defects, bone repair, tissue engineering' in Chinese and English, respectively. The types of literature included review, basic and clinical research. The literature was screened preliminarily by reading title and abstract, and the irrelevant articles were excluded.Finally 48 articles eligible for inclusion and exclusion criteria were enrolled for result analysis.RESULTS AND CONCLUSION: As an important component of bones, strontium plays an important role in the development and formation of bone. Strontium-doped bone substitute materials have become the hotspot of bone tissue engineering research.A large number of studies have confirmed that the incorporation of strontium can effectively improve the mechanical properties of bone substitute materials, improve the recruitment ability and differentiation ability of osteoblasts, and promote the osteogenesis and angiogenesis in vivo. However, there are still some shortcomings in the current research: the strontium-doping methods used in different studies are different, so the results are not comparable. The results of different studies on the amount of strontium doping are different. There is no relatively well-recognized strontium-incorporating concentration that can be used to induce osteogenic differentiation.
作者 张骏 尤奇 邹刚 葛振 刘毅 Zhang Jun;You Qi;Zou Gang;Ge Zhen;Liu Yi(First Department of Orthopedics,Zunyi Medical University,Zunyi 563000,Guizhou Province,China)
出处 《中国组织工程研究》 CAS 北大核心 2019年第18期2936-2940,共5页 Journal of Clinical Rehabilitative Tissue Engineering Research
关键词 锶元素 骨组织工程 骨缺损 骨修复 成骨细胞 破骨细胞 成骨能力 成血管能力 strontium bone tissue engineering bone defects bone repair osteoblasts osteoclasts osteogenic ability angiogenesis ability
作者简介 张骏,男,1992年生,四川省达州市人,汉族,遵义医学院在读硕士,主要从事组织工程和运动医学的研究;通讯作者:刘毅,教授,硕士生导师,遵义医学院附属医院骨一科,贵州省遵义市563000.
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