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年龄和性别对胃镜检查中笑气清醒镇静镇痛效果的影响 预览

Influences of age and gender on the sedative and analgesic effect of nitrous oxide inhalation during gastroscopy
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摘要 目的探讨年龄和性别对胃镜检查中笑气清醒镇静镇痛效果的影响。方法选取2017年3月至2018年7月在南方医科大学第三附属医院行笑气清醒镇静镇痛胃镜检查的311例患者为研究对象,按年龄分为青年组、中年组、老年组;按性别分为男性组、女性组。收集笑气化浓度及时间、Ramsay镇静分级、VAS疼痛评分、舒适度及不良反应等资料进行对比分析,并通过单因素分析和多因素分析探讨笑气镇静镇痛效果的影响因素。结果与青、中年组相比,老年组的笑气化浓度及时间更小(P <0. 05),其Ramsay镇静分级更高(P <0. 05)、VAS疼痛评分更低(P <0. 05)、舒适度更好(P <0. 05)。与男性组相比,女性组的笑气化浓度及时间更小(P <0. 05),其Ramsay镇静分级更高(P <0. 05)、VAS疼痛评分更低(P <0. 05)、舒适度更好(P <0. 05)。单因素分析显示年龄、性别与笑气镇静镇痛效果有关;多因素分析显示青年、中年及男性均是影响笑气镇静镇痛效果的独立危险因素。结论年龄和性别是胃镜检查中笑气清醒镇静镇痛效果的重要影响因素。老年患者、女性患者更容易达到笑气化状态且笑气镇静镇痛效果更好;与其他患者相比,笑气舒适胃镜技术更受益于老年患者及女性患者。 Objective To explore the influences of age and gender on the sedative and analgesic effects of nitrous oxide( N2O during gastroscopy. Methods The study was performed on 311 patients who underwent gastroscopy under the N2O inhalation. They were divided into the youth group,the middle-aged group and the elderly group according to their age. It is divided into male group and female group according to gender. The data of ideal concentration and time of N2O,Ramsay sedation level,VAS pain score,comfort level and adverse reactions were collected and the influences of age and gender on the sedative and analgesic effects of N2O were investigated through comparative analysis,single-factor analysis and multi-factor analysis. Results Compared with the young and middle-aged groups,the elderly group had a smaller ideal concentration and time of N2O( P < 0. 05),higher Ramsay sedation level( P < 0. 05),lower VAS pain score( P < 0. 05) and better comfort level( P < 0. 05). Compared with the male group,the female group showed a smaller ideal concentration and time of N2O( P < 0. 05),a higher Ramsay sedation level( P < 0. 05),a lower VAS pain score( P < 0. 05) and a better comfort level( P < 0. 05). Single factor analysis showed that age and gender were related to the sedative and analgesic effects of N2O. Multivariate analysis showed that young,middle-aged and male were independent risk factors for the sedative and analgesic effects of N2O. Conclusion Age and gender are the important factors influencing the sedative and analgesic effects of N2O during gastroscopy. Elderly patients and female patients are more likely to achieve the ideal anesthesia state and the sedative and analgesic effect of N2O are better. Compared with other patients,the comfortable gastroscope technology of N2O is more beneficial to elderly patients and female patients.
作者 王仁生 岳辉 徐胜浩 李立夫 黄必钦 陈培生 邓三花 彭芊芊 刘素英 WANG Ren-sheng;YUE Hui;XU Sheng-hao;LI Li-fu;HUANG Bi-qin;DENG San-hua;PENG Qian-qian;LIU Su-ying(Department of Gastroenterology,Third Affiliated Hospital of Southern Medical University,Guangzhou 510630,China)
出处 《现代消化及介入诊疗》 2019年第2期137-141,共5页 Modern Digestion & Intervention
关键词 胃镜检查 笑气镇静镇痛效果 年龄 性别 影响因素 gastroscopy the sedative and analgesic effects of N2O age gender influencing factor
作者简介 通讯作者:岳辉,E-mail:yh12070430@vip.sina.com
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