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蒙古族初诊2型糖尿病患者经胰岛素泵强化治疗的临床效果

Efficacy of intensive treatment with insulin pump in Mongolian patients with newly diagnosed type 2 diabetes
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摘要 目的探讨蒙古族初诊2型糖尿病(T2DM)患者经胰岛素泵强化治疗3年后血糖控制情况以及临床缓解率,旨在为开展蒙古族患者糖尿病的预防和控制提供依据。方法选取通辽市医院2014年8月—2015年12月收治的初诊T2DM经胰岛素泵强化治疗达到临床缓解期的患者240例为研究对象,分为观察组(蒙古族患者)和对照组(汉族患者),每组120例。比较两组患者治疗后的空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、胰岛β细胞指数(Homa-β)、胰岛素抵抗指数(Homa-IR)及临床缓解率。结果两组患者治疗3年后的FPG、2hPG、HbA1c、Homa-β和Homa-IR均优于治疗前,差异有统计学意义(P<0.05);观察组治疗3年后的FPG、2hPG和HbA1c高于对照组,差异均有统计学意义(P<0.05)。观察组的1年临床缓解率(28.33%)低于对照组(56.67%),差异有统计学意义(P<0.05);观察组的3年临床缓解率(8.33%)低于对照组(17.91%),差异有统计学意义(P<0.05);两组的2年临床缓解率比较,差异无统计学意义(P>0.05)。结论蒙古族初诊T2DM患者经胰岛素泵强化治疗后,血糖水平控制良好,但是,蒙古族患者血糖控制情况较汉族患者差,蒙古族患者的1年、3年临床缓解率低于汉族患者的临床缓解率。 Objective To investigate the blood glucose control status and clinical remission rate of newly diagnosed type 2 diabetes(T2DM)patients of Mongolian after intensive treatment with insulin pump for 3 years,and in order to provide evidence for the prevention and control of diabetes mellitus in Inner Mongolian patients.Methods Totally 240 cases of newly diagnosed T2DM patients admitted to Tongliao Hospital from August 2014 and December 2015 were selected as study subjects,and they were in the clinical remission stage after intensive treatment with insulin pump.The subjects were divided into the observation group(Mongolian nationality)and the control group(Han nationality),each 120 cases.These indicators such as fasting plasma glucose(FPG),2-h postload plasma glucose(2 hPG),hemoglobin A1c(HbA1c),homeostatic model assessmen-β(Homa-β)and homeostatic model assessmen-insulin resistance(Homa-IR),and three-year clinical remission rates were compared between the two groups.Results These indicators such as FPG,2 hPG,HbA1c,Homa-βand Homa-IR of the two groups after 3 years of treatment were better than those before treatment,and the differences were statistically significant(all P<0.05).Levels of FPG,2 hPG and HbA1c in the observation group were higher than those in the control group after 3 years of treatment,and the difference was statistically significant(all P<0.05).The one-year clinical remission rate and the threeyear clinical remission rate in observation were significantly lower than those in the control group(oneyear clinical remission rate:28.33%vs.8.33%;three-year clinical remission rate:56.67%vs.17.91%).The two-year clinical remission rate was not significantly different in the two groups(P>0.05).Conclusions After intensive treatment with insulin pump,the blood glucose level of newly diagnosed T2DM patients of Mongolian is well controlled.But the blood glucose control status of the Mongolian patients is worse than that of the Han patients.The one-year and three-year clinical remission rate of the Mongolian patien
作者 许英 杨敏 XU Ying;YANG Min(Department of Endocrinology,Tongliao Hospital,Tongliao,Inner Mongolian 028000,China)
出处 《慢性病学杂志》 2019年第4期486-488,492共4页 Chronic Pathematology Journal
基金 内蒙古自治区卫生计生科研计划项目(201701110).
关键词 2型糖尿病 初诊 强化治疗 蒙古族 Type 2 diabetes mellitus Newly diagnosed Intensive therapy Mongolian nationality
作者简介 通信作者:许英,大学本科,主任医师,研究方向:内分泌,E-mail:tlxuying@126.com。
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