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ER、PR、PCNA、C-CrbB-2在子宫肌瘤中的表达及其临床意义 预览 被引量:7

Expression of Estrogen Receptor,Progesterone Receptor,Proliferating Cell Nuclear Antigen and C-CrbB-2 in Uterine Leiomyoma and Its Clinical Significance
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摘要 目的探讨雌激素受体(ER)、孕激素受体(PR)、增殖细胞核抗原(PCNA)及癌基因(C-CrbB-2)在子宫肌瘤中的表达以及与子宫肌瘤生长的关系.方法应用免疫组化法测定50例子宫肌瘤内ER、PR、PCNA及C-CrbB-2表达的阳性率,并根据肌瘤的发病病程、临床症状、肌瘤的直径、数量以及不同的月经周期(卵泡期和黄体期)进行分组研究.结果肌瘤内ER、PR表达的阳性率与肌瘤直径之间有统计学差异.卵泡期肌瘤内的ER表达的阳性率高于黄体期(P<0.05).而PCNA及C-CrbB-2表达的阳性率与肌瘤无关系.结论子宫肌瘤的生长、发展与肌瘤内ER、PR含量的水平密切相关,而与细胞分裂增殖的关系不大,与癌基因的表达无关. Objective To investigate the expression of ER,PR,PCNA and C-CrbB-2 in uterine leiomyoma and its relationship with the growth of uterine leiomyoma.Method The positive rate of expression of ER,PR,PCNA and C-CrbB-2 in 50 cases of uterine leiomyoma was measured with immunochemistric method.The patients were divided into several groups according to the course of disease,symptom,diameter and number of uterine leiomyoma,menstrual cycle(proliferative phase and secretory phase).Results There were significant statistical differences between the positive rate of ER and PR expression and the diameter of uterine leiomyoma.The positive rate of ER expression in uterine leiomyoma during the proliferative phase was higher than that during the secretory phase(P<0.05).The positive rate of PCNA and C-CrbB-2 expression was not associated with uterine leiomyoma.Conclusions The growth of uterine leiomyoma is closely related to the contents of ER and PR,but hardly related to the division and proliferation of cells,and not related to the expression of oncogene.
作者 丁佩芳 程忠平 蒋允凯 DING Pei-fang,CHENG Zhong-ping,JIANG Yun-kai(Department of Obstetrics & Gynecology,The Central Hospital of Yangpu District,Shanghai 200090,China)
出处 《现代诊断与治疗》 CAS 2003年第3期 137-140,共4页 Modern Diagnosis & Treatment
关键词 子宫肌瘤 雌激素受体 孕激素受体 增殖细胞核抗原 C-CrbB-2 免疫组化法 Uterine leiomyoma Estrogen receptor Progesterone receptor Proliferating cell nuclear antigen C-CrbB-2
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  • 1曹泽毅主编;翁梨驹等副主编..中华妇产科学 第2版 上[M],1999:1345.

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