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基于膜及其集成过程的中药“绿色浓缩”技术研究进展、关键科学问题与对策

Research progress, key scientific problems and countermeasures of “green concentration” technology based on membrane and its integration process
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摘要 中药工业能耗惊人,能耗的重头浓缩工段的蒸汽耗量约占全厂的60%左右,甚至更高。膜浓缩技术具有'能耗小、成本低'的重要优势,但因不同膜过程本身技术原理所造成的各自缺陷,而受到制约。引进国际先进的膜集成设计策略与方法,针对有望适用于中药物料浓缩需求的'反渗透与膜蒸馏集成'的技术关键——浓缩过程对中药物料流变性的劣化及其对膜传质作用的拮抗,以代表性中药复方为实验体系,借鉴流变学理论与计算流体力学(CFD)手段,通过工艺过程动态精密分析,建立'时间-物料流变学特征-膜传质过程'三维模型;融合多学科手段,探索中药物料流变学规律及其对膜浓缩过程的影响,阐述膜浓缩过程对中药物料的传质作用及机制,寻找临界渗透压(反渗透过程)与临界通量(膜蒸馏过程)2个关键工艺参数的平衡点,探索'反渗透'与'膜蒸馏'2种膜过程的优化组合方案。破解膜浓缩工艺中药行业产业化的技术瓶颈,为其成套技术设备研制及工艺设计提供支撑,促进中药制药工程理论和技术创新。 The energy consumption of Chinese materia medica industry is astonishing.The steam consumption of the heavy concentrating section accounts for about 60%of the whole plant,or even higher.Membrane concentration technology has the important advantages of'low energy consumption and low cost',but it is restricted by the respective defects caused by the technical principles of different membrane processes.Our research group introduces the international advanced integrated design strategy and method in view of the key technology of'reverse osmosis and membrane distillation integration'which is expected to suitable for the concentrated demand of Chinese medicine pharmaceutical industry.Taking the representative Chinese herbal compound prescription as the experimental system,a three-dimensional model of'time-material rheological characteristics-membrane mass transfer process'was established by using rheological theory and computational fluid dynamics(CFD)as experimental system and dynamic and precise analysis of technological process.The rheological law of traditional Chinese medicine materials and its influence on membrane concentration process were explored by means of multi-disciplinary methods.The mass transfer effect and mechanism of membrane concentration process on traditional Chinese medicine materials were elaborated.The equilibrium points of critical osmotic pressure(RO process)and critical flux(membrane distillation process)were found.The optimal combination schemes of reverse osmosis(RO)and membrane distillation(MD)were explored.In short,we solved the key technical problems of the membrane concentration process,which provided support for the complete set of technical equipment and the technological design,and promoted the theoretical and technological innovation of TCM pharmaceutical engineering.
作者 潘林梅 李博 郭立玮 张刘红 石飞燕 杨晨 金唐慧 PAN Lin-mei;LI Bo;GUO Li-wei;ZHANG Liu-hong;SHI Fei-yan;YANG Chen;JIN Tang-hui(Jiangsu Botanical Medicine Refinement Engineering Research Center,Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处 《中草药》 CAS CSCD 北大核心 2019年第8期1768-1775,共8页 Chinese Traditional and Herbal Drugs
基金 国家自然科学基金资助项目(81274096) 国家自然科学基金资助项目(81303230) 国家自然科学基金资助项目(81673610) 国家自然科学基金资助项目(81773912) 2017中国工程院咨询项目(2017-XZ-08) 江苏省中药资源产业化过程协同创新中心分离平台建设项目(ZDXM-1-6,ZDXM-1-8) 江苏省高校优势学科建设工程资助项目 南京中医药大学校级创新团队资助.
关键词 中药制药工业 浓缩 膜集成 流变学 计算流体力学 Chinese materia medica pharmaceutical engineering concentration membrane and integration process rheology computational fluid dynamics
作者简介 第一作者:潘林梅,博士,副教授,主要研究方向为中药制药工程;通信作者:郭立玮,研究员,主要从事以膜技术为主体的中药复方分离工程研究。E-mail:guoliwei815@126.com;第一作者:李博,博士,副教授,主要研究方向为中药膜分离应用基础及中药制药工程。
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