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膜技术富集脉络宁注射液生产废水中小分子药效成分的工艺优化研究

Membrane technology for optimizing process optimization of small bioactive compounds in Mailuoning Injection factory effluene
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摘要 目的利用聚醚砜中空纤维膜对脉络宁注射液生产废水的小分子药效物质进行富集。方法以共性高分子(蛋白质、鞣质、淀粉、果胶)截留率和小分子药效物质绿原酸的渗透率为考察指标,优选出超滤膜过程停止时间和膜型号,进而采用Box-Behnken中心组合设计建立数学模型,优化出超滤膜过程的最佳工艺参数。结果在共性高分子截留率中,影响因素A(温度)>B(错流压差)>C(进料速率),并且与温度呈负相关性;在绿原酸透过率中,影响因素A(温度)>B(错流压差)>C(进料速率),并且在温度与速率一定时,绿原酸透过率与错流压差存在'∩'型关系。优化工艺结果为药液温度35℃,进料体积流量为262 mL/min,错流压差15.0 psi(1 psi=6.895 kPa),工艺验证绿原酸透过率为(91.470±0.988)%,高分子截留率为(80.080±2.296)%,综合评分为(85.780±1.641)%,RSD为0.46%,与预测工艺偏差较小。结论中空纤维膜对于生产废水中的小分子药效物质有良好的渗透率,并对共性大分子有优良的截留效果,是一种可持续的、绿色资源化利用方式。 Objective To enrich small bioactive compounds from Mailuoning Injection factory effluene by polyether sulfoxide hollow fiber membrane.Methods The retention rate of the common polymer(protein,tannin,starch,and pectin)and the permeability of the small molecule pharmacodynamic substance chlorogenic acid were the indicators,and the stop time and membrane type in ultrafiltration process were optimized.The temperature,pressure,and feed rate were investigated to determine the influence degree of each factor on the permeability and retention rate,and then the optimum process parameters of the ultrafiltration membrane process were optimized by using Box-Behnken design-response surface method.Results The sequence of common polymer retention rate from high to low is:the influencing factor A(temperature),B(pressure),C(feed rate),and there was a negative correlation with the temperature.For the chlorogenic acid transmission rate,the influencing factor A(temperature)was larger than B(pressure),and C(feed rate)was lowest.There was a'∩'relationship between chlorogenic acid permeability and pressure at a certain temperature and rate.The results of optimized process were as follows:liquid temperature was 35℃,feed rate was 262 mL/min,and membrane pressure was 15.0 psi(1 psi=6.895 kPa).The chlorogenic acid transmission rate was(91.470±0.988)%,and polymer retention rate was(80.080±2.296)%.The comprehensive score was(85.780±1.641)%and RSD was 0.46%.There was a small difference between the two processes.Conclusion Hollow fiber membrane,which is a sustainable and green resource utilization,has a good permeability for small bioactive compounds in wastewater,and has excellent retaining effect on common macromolecules.
作者 聂林峰 黄佳云 何成华 朱华旭 段金廒 邢卫红 郭立玮 李博 潘永兰 汤卫国 NIE Lin-feng;HUANG Jia-yun;HE Cheng-hua;ZHU Hua-xu;DUAN Jin-ao;XING Wei-hong;GUO Li-wei;LI Bo;PAN Yong-lan;TANG Wei-guo(College of Veterinary Medicine,Nanjing Agriculture University,Nanjing 210095,China;Jiangsu Province Traditional Chinese Medicine Resource Industrialization Process Collaborative Innovation Center,Nanjing University of Chinese Medicine,Nanjing 210023,China;Nanjing Tech University,Nanjing 211816,China;Jinling Pharmaceutical Company Limited Nanjing Jinling Pharmaceutical Factory Research Institute,Nanjing 210009,China)
出处 《中草药》 CAS CSCD 北大核心 2019年第8期1804-1810,1817共8页 Chinese Traditional and Herbal Drugs
基金 国家自然科学基金面上项目(81673610) 国家自然科学基金面上项目(81773912) 国家自然科学基金面上项目(81873015) 中国科学院咨询研究项目(2017-XZ-08) 江苏省科技厅重点研发计划——社会发展面上项目(BE2016754) 江苏省中药资源产业化过程协同创新中心重点项目(ZDXM-6) 江苏省中药资源产业化过程协同创新中心重点项目(ZDXM-8) 江苏省优势学科资助(PAPD).
关键词 绿原酸 超滤工艺 响应面分析法 共性高分子 生产废水 截留率 渗透率 chlorogenic acid ultrafiltration technology response surface analysis common polymer industrial wastewater retention rate permeability
作者简介 聂林峰,硕士,研究方向为中药资源开发与综合利用研究。Tel:18851176229,E-mail:2016107092@njau.edu.cn;通信作者:何成华,副教授,研究方向为民族药物开发与应用。Tel:(025)84395227,E-mail:hechenghua@njau.edu.cn;通信作者:朱华旭,研究员,研究方向为中药绿色分离技术及其产业化。Tel:(025)85811070,E-mail:huaxu72@126.com.
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