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阿托伐他汀钙联合依达拉奉对脑梗死患者血清脑源性神经生长因子、血管内皮生长因子、基质金属蛋白酶-9及肿瘤坏死因子水平影响研究

Effect on the serum levels of brain derived neurotrophic factor,vascular endothelial growth factor,matrix metalloproteinase-9 and tumor necrosis factor by atorvastatin calcium combined with edaravone in cerebral infarction patients
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摘要 目的探讨阿托伐他汀钙联合依达拉奉对脑梗死患者血清脑源性神经生长因子、血管内皮生长因子、基质金属蛋白酶-9及肿瘤坏死因子水平影响。方法收集大连市中心医院以脑梗死收住院患者78例,分为试验组和对照组。两组患者均予对症治疗和阿托伐他汀;试验组在此基础上加用依达拉奉。于两组患者治疗前、治疗第7天、第14天各进行1次血清BDNF、VEGF、MMP-9及TNF水平测定,对两组患者治疗前及治疗后两周进行NIHSS评分及ADL,判断疗效。结果(1)治疗后两组患者血清BDNF呈现持续上升趋势,VEGF、MMP-9及TNF-α水平均出现第7天上升、第14天下降,与对照组比较,试验组上升及下降均更为明显,差异均有统计学意义(均P<0.05);(2)治疗后两组患者NIHSS评分均下降、ADL评分均上升,与对照组相比,试验组NIHSS评分指标[(4.96±1.18)分比(6.44±1.57)分],ADL评分[(71.74±14.26)分比(64.45±13.78)分]均改善更显著,差异均有统计学意义(均P<0.05)。结论阿托伐他汀钙联合依达拉奉可更显著改善脑梗死患者血清BDNF、VEGF、MMP-9及TNF-α水平,对脑梗死的治疗、预后改善及提高患者生活质量有重要意义。 Objective To investigate the effect on the serum levels of brain derived neurotrophic factor,vascular endothelial growth factor,matrix metalloproteinase-9 and tumor necrosis factor by atorvastatin calcium combined with edaravone in cerebral infarction patients.Methods 78 cerebral infarction patients from our hospital were selected and randomly divided into the control group and the experiment group.Two groups were both treated by the symptomatic treatment and the atorvastatin.The experiment group were treated on the base of the control group with the edaravone.Serum levels of BDNF,VEGF,MMP-9 and TNF were tested and compared before treatment,treatment for seventh days and fourteenth days.NIHSS score and ADL were performed before and two weeks after treatment in the two groups.Results Compared with before treatment,the serum BDNF were higher(P<0.05),the VEGF、MMP-9 and TNF-a level were higher in 7 th day and lower in 14 th day(P<0.05),and the experiment group were more obviously(P<0.05).Compared with before treatment,the NIHSS score were lower(P<0.05),and the experiment group were more obviously(P<0.05).Conclusion Atorvastatin edaravone combined with atorvastatin calcium can significantly improve the cerebral infarction patients with BDNF,VEGF,MMP-9 and TNFa level,improve the treatment and prognosis of cerebral infarction and it is important to improve the quality of life of the patients.
作者 钟丽珍 徐涛 张大伟 赵华 王静 ZHONG Li-zhen;XU Tao;ZHANG Da-Wei;ZHAO Hua;WANG Jing(Department of Neurology,Dalian Municipal Central Hospital Affiliated of Dalian Medical University,Dalian 116033, China)
出处 《中国误诊学杂志》 CAS 2019年第2期62-65,共4页 Chinese Journal of Misdiagnostics
基金 河北省卫生健康委指导性课题(2018220).
关键词 阿托伐他汀钙 依达拉奉 脑梗死 脑源性神经生长因子 血管内皮生长因子 基质金属蛋白酶-9 肿瘤坏死因子 atorvastatin calcium edaravone cerebral infarction brain-derived nerve growth factor vascular endothelial growth factor matrix metalloproteinase-9 tumor necrosis factor
作者简介 通信作者:赵华,E-mail:757074270@qq.com;通信作者:王静,Email:55421436@qq.com
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