Objective: To investigate the occurrence, distribution and defending. Methods: Information of 895 in-hospital patients were epidemically investigated. Results: The total intercross infection rate was 7.04%. It was constituted by respiratory tract 52.38%, wounded 19.05%, digesting tract 9.52%. And checking-up rate of organisms in spacemen was 21.20%. Conclusion: Departments of internal medicine, pediatrics and surgery with cleaning wounded and sewing up are the main regions in town hospital.