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The role of p53 in developmental syndromes
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作者 Margot E.Bowen Laura D.Attardi 《分子细胞生物学报:英文版》 SCIE CAS CSCD 2019年第3期200-211,共12页
While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer,growing evidence indicates that increased p53 activity underlies the developmental defects in a wide range of genetic syndrome... While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer,growing evidence indicates that increased p53 activity underlies the developmental defects in a wide range of genetic syndromes.The inherited or de novo mutations that cause these syndromes affect diverse cellular processes,such as ribosome biogenesis,DNA repair,and centriole duplication,and analysis of human patient samples and mouse models demonstrates that disrupting these cellular processes can activate the p53 pathway.Importantly,many of the developmental defects in mouse models of these syndromes can be rescued by loss of p53,indicating that inappropriate p53 activation directly contributes to their pathogenesis.A role for p53 in driving developmental defects is further supported by the observation that mouse strains with broad p53 hyperactivation,due to mutations affecting p53 pathway components,display a host of tissue-specific developmental defects,including hematopoietic,neuronal,craniofacial,cardiovascular,and pigmentation defects.Furthermore,germline activating mutations in TP53 were recently identified in two human patients exhibiting bone marrow failure and other developmental defects.Studies in mice suggest that p53 drives developmental defects by inducing apoptosis,restraining proliferation,or modulating other developmental programs in a cell type-dependent manner.Here,we review the growing body of evidence from mouse models that implicates p53 as a driver of tissue-specific developmental defects in diverse genetic syndromes. 展开更多
关键词 P53 Mdm2 development EMBRYO CONGENITAL defect syndrome genetic DISORDER
SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity 预览
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作者 Chunlin Zuo Lijun Wang +11 位作者 Raghavendra M.Kamalesh Margot E.Bowen Douglas C.Moore Mark S.Dooner Anthony M.Reginato Qian Wu Christoph Schorl Yueming Song Matthew L.Warman Benjamin G.Neel Michael G.ehrlich Wentian Yang 《骨研究:英文版》 SCIE CAS CSCD 2018年第2期132-144,共13页
关键词 SOX9 骨胳 房间 调整 基因表达式 修改 RT-PCR 造骨细胞
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Study of the production of ∧0/b and -B/0 hadrons in pp collisions and first measurement of the ∧0/b→ J/ψ pK- branching fraction
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作者 R. Aaij B. Adeva +127 位作者 M. Adinolfi A. Affolder Z. Ajaltouni S. Akar J. Albrecht F. Alessio M. Alexander S. Ali G. Alkhazov P. Alvarez Cartelle A.A. Alves Jr S. Amato S. Amerio Y. Amhis L. An L. Anderlini J. Anderson G. Andreassi M. Andreotti J.E. AndrEws R.B. Appleby O. Aquines Gutierrez F. Archilli1 P. d'Argent A. Artamonov M. Artuso E. AslanidEs G. Auriemma M. Baalouch S. Bachmann J.J. Back A. Badalov C. Baesso W. Baldini R.J. B arlow C. Barschel S. Barsuk W. Barter V. Batozskaya V. Battista A. Bay L.Beaucourt J. Beddow F. Bedeschi I. Bediaga L.J. Bel V. Bellee N. Belloli I. Belyaev E. BEn-Haim G. Bencivenni S. Benson J. Benton A. Berezhnoy R. Bernet A. Bertolin M.-O. Bettler M. van Beuzekom A. Bien S. Bifani P. Billoir T. Bird A. Birnkraut A. Bizzeti T. Blake F. Blanc J. Blouw S. Blusk V. Bocci A. Bondar N. Bondar W. Bonivento S. Borghi M. Borsato T.J.V. Bowcock E. Bowen C. Bozzi S. Braun M.Britsch T. Britton J. Brodzicka N.H. Brook E. Buchanan A. Bursche J. Buytaert S. Cadeddu R. Calabrese M. Calvi M. Calvo Gomez P. Campana D. Campora Perez L. Capriotti1 A. Carbone G. Carboni R. cardinale A. Cardini P. Carniti L. Carson K. Carvalho Akiba G. Casse L. Cassina L. Castillo Garcia M. Cattaneo Ch. Cauet G. Cavallero R. Cenci M. Charles Ph. Charpentier M. Chefdeville S. Chen S.-F. Cheung N. Chiapolini M. Chrzaszcz X. Cid Vidal G. Ciezarek P.E.L. ClarkE M. Clemencic H.V. Cliff J. Closier V. Coco J. Cogan E. CognEras V. Cogoni L. Cojocariu G. Collazuol P. Collins A. Comerma-Montells A. Co 《中国物理C:英文版》 SCIE CAS CSCD 2016年第1期1-16,共16页
The product of the A_b~0(B~0) differential production cross-section and the branching fraction of the decay A_b~0→J/ψpK~-(B~0→J/ψK~*(892)~0) is measured as a function of the beauty hadron transverse momentum,p_T,a... The product of the A_b~0(B~0) differential production cross-section and the branching fraction of the decay A_b~0→J/ψpK~-(B~0→J/ψK~*(892)~0) is measured as a function of the beauty hadron transverse momentum,p_T,and rapidity,y.The kinematic region of the measurements is p_T <20 GeV/c and 2.0<y<4.5.The measurements use a data sample corresponding to an integrated luminosity of 3fb~(-1) collected by the LHCb detector in pp collisions at centre-of-mass energies s~(1/2)=7 TeV in 2011 and s~(1/2)= 8TeV in 2012.Based on previous LHCb results of the fragmentation fraction ratio,f_∧_b~0/f_d,the branching fraction of the decay ∧_b~0→J/ψpK~- is measured to be B(∧_b~0→J/ψpK~-)=(3.17±0.04±0.07±0.34_(-0.28)~(+0.45)×10~(-4)where the first uncertainty is statistical,the second is systematic,the third is due to the uncertainty on the branching fraction of the decay B~0→J/ψK~*(892)~0,and the fourth is due to the knowledge of f_∧_b~0/f_d.The sum of the asymmetries in the production and decay between A_b and A_b~0 is also measured as a function of p_T and y.The previously published branching fraction of A_b~0→J/φpπ~-,relative to that of A_b~0→J/ψpK~-,is updated.The branching fractions of∧_b~0→P_c~+(→J/ψp)K~- are determined. 展开更多
关键词 一次测量 分数 pp 强子 生产 不确定性 分支比 产生截面
用DRIS和临界值法对番木瓜组织分析数据的分析比较 预览
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作者 John E.Bowen 张华平 《世界热带农业信息》 1993年第3期36-40,共5页
用综合诊断施肥法(DRIS)和临界值法鉴定温室沙培及商业大田定植番木瓜(Papaya carica L.,cv.Solo)的矿质营养缺乏情况。无矿质营养缺乏症(即“完全”处理)的沙培植株,DRIS指数全为正值,表明植株的生长和发育确实没有营养限制,根据DRIS... 用综合诊断施肥法(DRIS)和临界值法鉴定温室沙培及商业大田定植番木瓜(Papaya carica L.,cv.Solo)的矿质营养缺乏情况。无矿质营养缺乏症(即“完全”处理)的沙培植株,DRIS指数全为正值,表明植株的生长和发育确实没有营养限制,根据DRIS,肉眼可看出缺乏症的大田植株,其刚老熟叶片的叶柄最缺乏的元素是P、Fe和Zn。在所有出现营养不平衡症状的植株中,P的浓度低于临界水平。这些植株的DRIS指数为负值可证实这点。Fe和Zn的DRIS指数也为负值,表明这些微量元素可能不足。然而,组织中Fe和Zn的实际浓度完全处于或高于适宜范围。因此,毒性可能是在症状表现方面起作用的因素,尤其是Zn。与健康的植株比较,不健康植株的镁浓度增加,但DRIS指数未能确定这是起作用的因素。DRIS结合临界值法分析植株组织的分析数据,似乎是鉴定番木瓜营养缺乏的一种有效手段。 展开更多
关键词 临界值 适宜范围 DRIS 施肥法 健康植株 营养缺乏 矿质营养 组织分析 镁浓度 实际浓度
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如何预防顾客失误
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作者 Stephen S.Tax Mark Colgate +1 位作者 David E.Bowen 康路(编译) 《商学院》 2006年第7期 55,共1页
大多数人往往忽略了顾客在提高服务质量过程中的作用,设想一下,如果你不努力,那么再优秀的健美教练也不能帮你塑造出好的体形。既然顾客在服务过程中扮演着和服务提供商一样重要的角色,那么我们应该采取措施来减少顾客的失误。我们... 大多数人往往忽略了顾客在提高服务质量过程中的作用,设想一下,如果你不努力,那么再优秀的健美教练也不能帮你塑造出好的体形。既然顾客在服务过程中扮演着和服务提供商一样重要的角色,那么我们应该采取措施来减少顾客的失误。我们列举了五类预防顾客失误的战略。 展开更多
关键词 顾客 预防 服务提供商 服务质量 服务过程
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