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Chemical Constituents from Stems of Cistanches deserticola
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作者 Mavis Boakye-Yiadom Li-feng Han +4 位作者 Wei Li Yi Zhang Er-wei Liu Xin-bo Song Tao Wang 《中草药:英文版》 CAS 2016年第3期293-296,共4页
Objective To study the chemical constituents in the stems of Cistanches deserticola. Methods The compounds were purified by various column chromatographic methods and their structures were elucidated by spectroscopic(... Objective To study the chemical constituents in the stems of Cistanches deserticola. Methods The compounds were purified by various column chromatographic methods and their structures were elucidated by spectroscopic(1D, 2D NMR, IR, [?]D, and MS) and chemical analyses. Results Seven compounds were isolated and identified as kankanoside D1(1), ajugol(2), cistanin(3), uridine(4), adenosine(5), 6-deoxycatalpol(6), and kankanoside D(7). Conclusion Compound 1 is a new compound. 展开更多
关键词 化学成分 肉苁蓉 鉴定结果 二维NMR 化合物 柱色谱法 光谱分析
Simultaneous Determination of Pinoresinol Di-gluco-pyranoside and Pinoresinol Glucoside in Rat Plasma by HPLC-tandem MS/MS for Pharmacokinetic Study
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作者 Er-wei Liu Yan-ping Lin +6 位作者 Lei Wang Yan Huo Ying-yue Zhang Jia-ding Guo Li-feng Han Yan-xu Chang Xiu-mei Gao 《中草药:英文版》 CAS 2016年第4期337-343,共7页
Objective Pinoresinol di-glucopyranoside(PDG) is one of the main active lignans of Eucommiae Cortex considered to be a high-quality antihypertensive drug. In this study the pharmacokinetic process of PDG and its prima... Objective Pinoresinol di-glucopyranoside(PDG) is one of the main active lignans of Eucommiae Cortex considered to be a high-quality antihypertensive drug. In this study the pharmacokinetic process of PDG and its primary in vivo metabolite pinoresinol glucoside(PG) in the portal and jugular vein were surveyed and evaluated simultaneously. Methods A sensitive high-performance liquid chromatography coupled with tandem quadruple mass spectrometry(HPLC-MS/MS) method and sample preparation protocol were developed and validated in method of selectivity, sensitivity, precision, stability, and extraction recovery for the simultaneous determination of PDG and its primary metabolite PG in rat plasma. The double intubation technique was used to simultaneously collect blood from common jugular vein and hepatic portal vein after single ig administration of PDG. Results Using this method, the quantification linearity ranges of PDG and PG in rat plasma were both 0.05-100 ng/mL. This method was successfully applied to the evaluation of the absolute oral bioavailability of PDG and determination of the pharmacokinetic properties of PDG and PG after ig administration of single dose in rats. The bioavailability of PDG at common jugular vein was 51.3% compared to that of 91.6% at hepatic portal vein. Conclusion We conclude that liver is the major conversion site of PDG to PG. 展开更多
关键词 common jugular vein hepatic portal vein pharmacokinetics pinoresinol di-gluco-pyranoside pinoresinol glucoside
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