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Primary cilia as a novel horizon between neuron and environment 预览
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作者 Gregory W.Kirschen Qiaojie Xiong 《中国神经再生研究:英文版》 SCIE CAS CSCD 2017年第8期1225-1230,共6页
The primary cilium, a hair-like sensory organelle found on most mammalian cells, has gained recent attention within the field of neuroscience. Although neural primary cilia have been known to play a role in embryonic ... The primary cilium, a hair-like sensory organelle found on most mammalian cells, has gained recent attention within the field of neuroscience. Although neural primary cilia have been known to play a role in embryonic central nervous system patterning, we are just beginning to appreciate their importance in the mature organism. After several decades of investigation and controversy, the neural primary cilium is emerging as an important regulator of neuroplasticity in the healthy adult central nervous system. Further, primary cilia have recently been implicated in disease states such as cancer and epilepsy. Intriguingly, while primary cilia are expressed throughout the central nervous system, their structure, receptors, and signaling pathways vary by anatomical region and neural cell type. These differences likely bear relevance to both their homeostatic and neuropathological functions, although much remains to be uncovered. In this review, we provide a brief historical overview of neural primary cilia and highlight several key advances in the field over the past few decades. We then set forth a proposed research agenda to fill in the gaps in our knowledge regarding how the primary cilium functions and malfunctions in nervous tissue, with the ultimate goal of targeting this sensory structure for neural repair following injury. 展开更多
关键词 神经元 原发性 纤毛 地平线 中枢神经系统 环境 哺乳动物细胞 神经可塑性
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The radial organization of neuronal primary cilia is acutely disrupted by seizure and ischemic brain injury
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作者 Gregory W. Kirschen Hanxiao Liu +3 位作者 Tracy Lang Xuelin Liang Shaoyu Ge Qiaojie Xiong 《生物学前沿:英文版》 CAS CSCD 2017年第2期124-138,共15页
Neuronal 主要的睫是极其涉及中央神经系统(CNS ) 的合适的生长,发展,和功能的感觉细胞器。最近的工作也建议他们在 CNS 的上下文发信号损害,和那反常睫的发信号可以在神经病学的疾病被含有。我们确定了的方法 neuronal 的分发在整... Neuronal 主要的睫是极其涉及中央神经系统(CNS ) 的合适的生长,发展,和功能的感觉细胞器。最近的工作也建议他们在 CNS 的上下文发信号损害,和那反常睫的发信号可以在神经病学的疾病被含有。我们确定了的方法 neuronal 的分发在整个由为主要的睫标记 adenylyl cyclase III (ACIII ) 染色并且关于全球、本地的并列飞机测量主要的睫的角度的 immunohistochemical 的正常成年老鼠大脑的主要的睫排列。我们然后介绍了尖锐大脑 insulttemporal 的二个不同模型脑叶抓住和服的局部缺血,和 re-examined neuronal 主要的睫分发,以及睫的长度和神经原怀有的比例睫。在基础条件下面的结果,外皮的睫关于外皮的表面放射状地排列自己,当时在有牙齿的回转的睫关于小粒房间层放射状地排列自己。在 striatum 和丘脑的神经原的睫由对比,展出睫的安排的宽分布。在尖锐大脑侮辱的两个盒子中,主要的睫排列显著地以一种区域特定的方式被破坏,与优先地破坏的侮辱影响的区域。进一步,二个模型在睫的长度上支持了微分效果,当仅仅局部缺血模型减少了时 ciliated 房间的比例。结论这些调查结果为 neuronal 的地区性的解剖组织提供证据在成年大脑的主要的睫并且建议各种各样的大脑侮辱可以破坏这个组织。 展开更多
关键词 缺血性脑损伤 纤毛细胞 神经元 急性 组织 径向 中枢神经系统损伤 神经系统疾病
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