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Differences in symptoms and pre-hospital delay among acute myocardial infarction patients according to ST-segment elevation on electrocardiogram: an analysis of China Acute Myocardial Infarction (CAMI) registry
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作者 Rui Fu Chen-Xi Song +6 位作者 Ke-Fei Dou Jin-Gang Yang Hai-Yan Xu Xiao-Jin Gao Qian-Qian Liu Han Xu Yue-Jin Yang 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第5期519-524,共6页
Background: Approximately 70% patients with acute myocardial infarction (AMI) presented without ST-segment elevation on electrocardiogram. Patients with non-ST segment elevation myocardial infarction (NSTEMI) often pr... Background: Approximately 70% patients with acute myocardial infarction (AMI) presented without ST-segment elevation on electrocardiogram. Patients with non-ST segment elevation myocardial infarction (NSTEMI) often presented with atypical symptoms, which may be related to pre-hospital delay and increased risk of mortality. However, up to date few studies reported detailed symptomatology of NSTEMI, particularly among Asian patients. The objective of this study was to describe and compare symptoms and presenting characteristics of NSTEMI vs. STEMI patients. Methods: We enrolled 21,994 patients diagnosed with AMI from China Acute Myocardial Infarction (CAMI) Registry between January 2013 and September 2014. Patients were divided into 2 groups according to ST-segment elevation: ST-segment elevation (STEMI) group and NSTEMI group. We extracted data on patients' characteristics and detailed symptomatology and compared these variables between two groups. Results: Compared with patients with STEMI (N=16,315), those with NSTEMI (N=5679) were older, more often females and more often have comorbidities. Patients with NSTEMI were less likely to present with persistent chest pain (54.3% vs.71.4%), diaphoresis (48.6% vs.70.0%), radiation pain (26.4% vs.33.8%), and more likely to have chest distress (42.4% vs.38.3%) than STEMI patients (all P<0.0001). Patients with NSTEMI were also had longer time to hospital. In multivariable analysis, NSTEMI was independent predictor of presentation without chest pain (odds ratio: 1.974, 95% confidence interval:1.849-2.107). Conclusions: Patients with NSTEMI were more likely to present with chest distress and pre-hospital patient delay compared with patients with STEMI. It is necessary for both clinicians and patients to learn more about atypical symptoms of NSTEMI in order to rapidly recognize myocardial infarction. 展开更多
关键词 Non-ST segment elevation myocardial infarction SYMPTOM assessment Time to treatment
Clinical significance of diabetes on symptom and patient delay among patients with acute myocardial infarction—an analysis from China Acute Myocardial Infarction(CAMI)registry 预览
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作者 Rui FU Si-Dong LI +9 位作者 Chen-Xi SONG Jing-Ang YANG Hai-Yan XU Xiao-Jin GAO Yi XU Jian-Ping ZENG Jun-Nong LI Ke-Fei DOU Yue-Jin YANG on behalf of the CAMI Registry study group Beijing,China 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第5期395-400,共6页
Background Diabetes is frequently associated with poor prognosis among acute myocardial infarction(AMI)patients.Patients with these comorbidities often have atypical symptoms and subsequent delay in treatment.Few stud... Background Diabetes is frequently associated with poor prognosis among acute myocardial infarction(AMI)patients.Patients with these comorbidities often have atypical symptoms and subsequent delay in treatment.Few studies have reported detailed AMI symptoms in patients with diabetes.This study compared AMI symptoms and presentation characteristics between diabetics and non-diabetics.Methods We included patients from the China AMI registry diagnosed with AMI between January 2013 and September 2014.Baseline characteristics,symptomology,and delay in treatment were compared between diabetics and non-diabetics.Multivariable logistic regression analysis was used to explore independent predictors of atypical symptoms.Results A total of 4450(20.2%)patients had diabetes.They were older,more often women,higher in body mass index,and more likely to have non-ST segment elevation myocardial infarction.Fewer diabetic patients presented with persistent precordial chest pain(63.1%vs.68%,P<0.0001),diaphoresis(60.1%vs.65.6%,P<0.0001),fatigue(16.7%vs.18.3%,P=0.0123),and incontinence(0.4%vs.0.7%,P=0.0093).Time to hospital presentation was longer among patients with diabetes than those without.In multivariable analysis,diabetes was identified as an independent predictor of atypical symptoms(OR:1.112,95%CI:1.034?1.196).Conclusions Our study is the first large-scale study providing evidence that diabetics are less likely to present with typical chest pain and more likely to experience treatment delay when suffering from an AMI.Our results may increase clinician awareness of recognizing AMI patients rapidly to reduce diagnosis and treatment delay,particularly in the context of diabetes. 展开更多
关键词 Acute myocardial infarction DIABETES SYMPTOMS Patient delay
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Dish Verification Antenna China for the SKA:design, verification and status
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作者 Biao Du Yang Wu +13 位作者 Yuan-Peng Zheng Xiao-Ming Chai Guo-Xi Liu Hai-Dong Wang Yi-Fan Zhang Sheng-Hua Yu Bin Liu Ye-Zhao Yu Hong-Wei Xi Long Chen Lei Yu Dong-Liang Liu Cheng-Jin Jin Bo Peng 《天文和天体物理学研究:英文版》 SCIE CAS CSCD 2019年第6期97-108,共12页
The Square Kilometre Array(SKA) will be the world’s largest synthesis radio telescope, which is designed to answer major scientific questions such as those relating to the cosmic origin and fundamental forces in the ... The Square Kilometre Array(SKA) will be the world’s largest synthesis radio telescope, which is designed to answer major scientific questions such as those relating to the cosmic origin and fundamental forces in the universe. With the SKA entering into the phase of pre-construction, more than 100 institutes in about 20 countries including China have been involved in the associated key technology development.The Dish Verification Antenna China(DVA-C) is a concept prototype which has been built to meet the requirements of the SKA’s scientific goals. It utilizes a unique skin-and-rib structure with single-piece panel reflectors. This paper presents details on the design and measured performances of DVA-C, as well as the preliminary observational results. Current applications of the DVA-C are also introduced. 展开更多
关键词 Square Kilometre Array radio TELESCOPE dish-single-piece panel
Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review
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作者 Yang Li Pei-Yuan Li +26 位作者 Shi-Jing Sun Yuan-Zhang Yao Zhan-Fei Li Tao Liu Fan Yang Lian-Yang Zhang Xiang-Jun Bai Jing-Shan Huo Wu-Bing He Jun Ouyang Lei Peng Ping Hu Yan-An Zhu Ping Jin Qi-Feng Shao Yan-Feng Wang Rui-Wu Dai Pei-Yang Hu Hai-Ming Chen Ge-Fei Wang Yong-Gao Wang Hong-Xu Jin Chang-Ju Zhu Qi-Yong Zhang Biao Shao Xi-Guang Sang Chang-Lin Yin 《中华创伤杂志:英文版》 CAS CSCD 2019年第1期1-11,共11页
Vacuum sealing drainage (VSD) is frequently used in abdominal surgeries. However, relevant guidelines are rare. Chin ese Trauma Surge on Associati on orga nized a committee composed of 28 experts across China in July ... Vacuum sealing drainage (VSD) is frequently used in abdominal surgeries. However, relevant guidelines are rare. Chin ese Trauma Surge on Associati on orga nized a committee composed of 28 experts across China in July 2017, aiming to provide an evidence-based recommendation for the application of VSD in abdominal surgeries.Eleven questions regarding the use of VSD in abdominal surgeries were addressed:(1) which type of materials should be respectively chosen for the intraperitoneal cavity, retroperitoneal cavity and superficial incisions?(2) Can VSD be preventively used for a high-risk abdominal incision w让h primary suture?(3) Can VSD be used in severely contaminated/infected abdominal surgical sites?(4) Can VSD be used for temporary abdominal cavity closure under some special conditions such as severe abdominal trauma, infection, liver transplantation and intra-abdominal volume increment in abdominal compartment syndrome?(5) Can VSD be used in abdominal organ inflammation, injury, or postoperative drainage?(6) Can VSD be used in the treatment of intestinal fistula and pancreatic fistula?(7) Can VSD be used in the treatment of intra-abdominal and extra-peritoneal abscess?(8) Can VSD be used in the treatment of abdominal wall wounds, wound cavity, and defects?(9) Does VSD in crease the risk of bleeding?(10) Does VSD increase the risk of intestinal wail injury?(11) Does VSD increase the risk of peritoneal adhesion? Focusing on these questions, evidence-based recommendations were given accordingly. VSD was strongly recommended regarding the questions 2-4. Weak recommendations were made regarding questions 1 and 5-11. Proper use of VSD in abdominal surgeries can lower the risk of infection in abdominal incisions with primary suture, treat severely contaminated/infected surgical sites and facilitate temporary abdominal cavity closure. 展开更多
关键词 GUIDELINE Vacuum SEALING drainage ABDOMINAL surgery
一种高效的面向动态有向图的增量强连通分量算法
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作者 廖小飞 陈意诚 +3 位作者 张宇 金海 刘海坤 赵进 《中国科学:信息科学》 CSCD 北大核心 2019年第8期988-1004,共17页
强连通分量(strongly connected component, SCC)算法可以将一个有向图缩略为有向无环图(directed acyclic graph, DAG),广泛应用于可达性查询等有向图分析应用.尽管现有工作已经提出多种面向静态有向图的强连通分量算法,但是它们需要... 强连通分量(strongly connected component, SCC)算法可以将一个有向图缩略为有向无环图(directed acyclic graph, DAG),广泛应用于可达性查询等有向图分析应用.尽管现有工作已经提出多种面向静态有向图的强连通分量算法,但是它们需要高额的运行时开销来反复对整个图进行全量计算,以响应现实世界中普遍存在的动态有向图结构的频繁变化.其实,在通常情况下,动态有向图每次改变量极小(少于5%).其允许我们以增量的方式对动态有向图进行强连通分量计算,以缩短响应时间.因此,为解决此问题,本文提出了一种高效的面向动态有向图的增量强连通分量算法Incremental Strongly Connected Components Algorithm,简称Inc-SCC,通过对不必要的计算进行裁剪以减少算法的数据访问量和计算量,并利用SCC的不相交性进行并行处理以提升SCC计算效率.其次,提出了一种启发式优化方法进一步加快算法收敛速度.实验结果显示,本方法可以用于实时响应有向图持续性动态变化,并且当整个有向图的边变化比例为5%时,本方法相对于现有算法的加速比可达2.8到12倍,当整个有向图的边变化比例为0.5%时,本方法相对于现有算法的加速比可达2.9到12倍. 展开更多
关键词 强连通分量 动态有向图 增量计算 收敛 有向无环图
The role of miRNA21 in hippocampal neurons of rats with pentylenetetrazol-induced epilepsy and its mechanism
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作者 Dong-Hai Liu Tian-Ning Zhao +7 位作者 Jia-Qi Yang Xue-Tong Tao Jing-Bo Zhang Yu-Ran Chen Lu-Lu Yang Xue Liu Hai-Peng Song Jin-Ling Zhu 《海南医科大学学报(英文版)》 2019年第10期23-27,共5页
Objective: To investigate the expression of miRNA21 in hippocampus of rats with pentylenetetrazol-induced epilepsy and its possible mechanism. Methods: Twenty-four healthy male wister rats was randomly divided into tw... Objective: To investigate the expression of miRNA21 in hippocampus of rats with pentylenetetrazol-induced epilepsy and its possible mechanism. Methods: Twenty-four healthy male wister rats was randomly divided into two groups, the normal group and the epilepsy group. The Racine grade scores of the two groups of rats were recorded to evaluate the establishment of a rat model of epilepsy. The differentially expressed of microRNAs targeting bcl-2 in the hippocampus of epileptic rats was screened by bioinformatics method. The expression of microRNA21 in hippocampus of epileptic rats was verified by qRT-PCR. Western blot and immunohistochemistry were used to detect the expression of Bcl-2 in rat hippocampus;Hoechst 33258 was used to detect the apoptosis of rat hippocampal neurons. Results: The Racine score of the rats in the epilepsy group was significantly higher than that in the normal control group (P<0.01). Compared with the normal group, the expression of miRNA21 in the hippocampus of the epileptic group increased (P<0.01) and the expression of Bcl-2 decreased (P<0.01). Conclusion: Epilepsy can up-regulate the expression of miRNA21 in rat hippocampal neurons, and it may further induce apoptosis of hippocampal neurons by down-regulating Bcl-2, which may affect epileptic rats. 展开更多
关键词 EPILEPSY miRNA21 Bcl-2 APOPTOSIS HIPPOCAMPAL NEURON
实习生及新上岗医务人员艾滋病及艾滋病职业暴露防护认知、态度行为调查分析 预览
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作者 栾艳 向茜 +7 位作者 李勤 黄海 徐静 王琳玲 丁丽莉 张晋 张弢 孙海滨 《医学教育研究与实践》 2019年第2期309-314,共6页
目的调查我院实习生及新上岗医务人员艾滋病及艾滋病职业暴露防护认知及态度行为现状。方法设计调查问卷,选取我院2015~2017年在院实习的预防医学、护理专业实习生及新上岗临床住院医师作为研究对象进行问卷发放填写。结果本次调查对象... 目的调查我院实习生及新上岗医务人员艾滋病及艾滋病职业暴露防护认知及态度行为现状。方法设计调查问卷,选取我院2015~2017年在院实习的预防医学、护理专业实习生及新上岗临床住院医师作为研究对象进行问卷发放填写。结果本次调查对象对艾滋病基本知识掌握较好,除对'窗口期、潜伏期、非传播途径(蚊虫叮咬)、疫苗/转归、病毒抵抗力'的正答率偏低外,其余各项均达85%以上。对艾滋病职业暴露防护认知欠佳,除对'普遍防护原则、洗手、戴手套、使用针头废弃物处理、暴露后决定感染HIV的条件'的正答率达85%以上,其余各项均偏低,甚至不足50%。仅有40.42%/59.05%/56.97%的学生愿意与HIV感染者一起学习工作/为HIV/AIDS患者服务/会主动参加艾滋病防治相关讲座,仍有48.42%的学生为HIV/AIDS患者进行医疗服务时感到害怕和恐惧。结论实习医学生及新上岗医务人员对艾滋病及艾滋病职业暴露防护相关知识掌握不全面、不系统,对HIV/AIDS患者存在歧视态度,应加强教育培训。 展开更多
关键词 医学生 艾滋病 职业暴露 防护认知 态度行为
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Development and validation of a model to determine risk of refractory benign esophageal strictures 预览
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作者 Qing Lu Tian-Tian Lei +5 位作者 Yi-Lan Wang Hai-Lin Yan Bo Lin Lin-Lin Zhu Hong-Sheng Ma Jin-Lin Yang 《世界临床病例杂志》 2019年第13期1623-1633,共11页
BACKGROUND Current research has identified several risk factors for refractory benign esophageal strictures (RBES), but research is scarce on the prediction of RBES in benign esophageal strictures patients. Meanwhile,... BACKGROUND Current research has identified several risk factors for refractory benign esophageal strictures (RBES), but research is scarce on the prediction of RBES in benign esophageal strictures patients. Meanwhile, the long-term outcomes of RBES remain unclear. The aim of this study was to develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures. And we also explored the long-term outcomes and safety in patients with RBES. AIM To develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures, based on the demographic data and endoscopic findings. METHODS A total of 507 benign esophageal stricture patients treated by dilation alone or in combination with stenting were retrospectively enrolled between January 2009 and February 2018. The primary outcome was to establish a risk-scoring model predicting RBES in benign esophageal strictures. The secondary outcome was to explore the clinical effectiveness and adverse events in patients with RBES. RESULTS In the study, age, etiology, and number and length of strictures were the independent risk factors for the refractory performance of benign esophageal strictures. According to risk factors of benign esophageal strictures, a risk-scoring model for predicting RBES in benign esophageal strictures was established: The risk score ranged from 0 to 8 points, and the risk scores were divided into low risk (0-2 points), intermediate risk (3-5 points), and high risk (6-8 points). The proportions of RBES in the corresponding risk categories were 1.0%, 12.2%, and 76.0%, respectively. Among 507 patients, 57 had RBES (39 males;median age, 60 years). The success rate of dilation treatment (51.2%, 21/41) was higher than that of stent placement (37.5%, 6/16). CONCLUSION In this study, 11.3%(57/507) patients had RBES at our hospital. The risk-scoring model predicting RBES in benign esophageal strictures could predict the longterm outcome of patients with strictures ahead. 展开更多
关键词 REFRACTORY BENIGN ESOPHAGEAL STRICTURES ESOPHAGEAL DILATION ESOPHAGEAL STENTS Long-term outcomes Retrospective analysis
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基于卡门涡街的水下振动能量采集器的设计与研究(英文) 预览
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作者 王海 金标 +3 位作者 姚刚 杨春来 郑衍畅 文莉 《传感技术学报》 CAS CSCD 北大核心 2019年第3期469-475,共7页
针对传统的单自由度压电能量采集器工作带宽窄的现状,提出了在水下流激振动环境下的一种基于卡门涡街的二自由度宽频压电能量采集器来提高压电能量采集器的带宽。3种二自由度压电能量采集器分别被设计、制造,并且测试了能量采集性能。... 针对传统的单自由度压电能量采集器工作带宽窄的现状,提出了在水下流激振动环境下的一种基于卡门涡街的二自由度宽频压电能量采集器来提高压电能量采集器的带宽。3种二自由度压电能量采集器分别被设计、制造,并且测试了能量采集性能。结果表明,采用二自由度能量采集器比采用传统的单自由度能量采集器具有更好的采集效率。根据仿真和实验结果,H型压电能量采集器具有更好的振动能量采集效率。 展开更多
关键词 无线传感网络 压电能量采集器 卡门涡街 二自由度
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断路器断口防入侵波雷害研究
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作者 谢海 黄金 张翌晖 《高压电器》 CAS CSCD 北大核心 2019年第10期176-181,共6页
针对全国近年大量加装的线路型终端避雷器,文中运用雷电波陡度理论,首创性推导出35~500kV线路采用线路型终端氧化锌避雷器时断路器断口所承受的入侵雷电波过电压计算公式。同时通过公式计算表明:线路型终端避雷器不满足绝缘配合要求,因... 针对全国近年大量加装的线路型终端避雷器,文中运用雷电波陡度理论,首创性推导出35~500kV线路采用线路型终端氧化锌避雷器时断路器断口所承受的入侵雷电波过电压计算公式。同时通过公式计算表明:线路型终端避雷器不满足绝缘配合要求,因而不能有效保护断路器断口;而变电站型终端避雷器满足绝缘配合要求,能有效保护断路器断口。这是全国各电压等级线路在大量加装线路型终端避雷器后断路器断口击穿事件仍时有发生的根本原因,也是文中重点论述并提醒行业、协会对反事故措施文件及相关技术规范尽快纠正的依据。 展开更多
关键词 入侵雷电波 断路器断口 线路型终端避雷器 变电站型终端避雷器 过电压
Temporal and spatial evolution of surface sediments characteristics in the Dagu River estuary and their dynamic response mechanism 预览
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作者 Xiao-ying Chen Da-hai Liu +3 位作者 Ping Yin Jin-qing Liu Ke Cao Fei Gao 《中国地质(英文)》 2019年第3期325-332,共8页
Based on the 39 surface sediment samples collected in the flood season and the dry season in 2012 respectively and the measured hydrological data in October 2012, the sediment grain size characteristics has been analy... Based on the 39 surface sediment samples collected in the flood season and the dry season in 2012 respectively and the measured hydrological data in October 2012, the sediment grain size characteristics has been analyzed and the response mechanism of surface sediments to estuarine hydrodynamics was revealed by calculating the range of waves and tidal currents. The results show that:(1) The grain size of the surface sediment samples decreased gradually from land to sea in the flood season. The fine sediment was redistributed under marine hydrodynamics in the dry season and the sediments showed coarser tendency ingeneral;(2) tidal current stirring sediment was very obvious in Dagu River estuary area, and wave stirring sediments mainly occurred in the tidal flat area and estuary sand bar area;(3) in the flood season, surface sediment sat the estuary were transported towards south and southeast. In the dry season, surface sediments were transported towards southwest at the north area of Jiaozhou Bay Bridge, and sediments were transported towards northeast area at the south of Jiaozhou Bay Bridge. 展开更多
关键词 Dagu River ESTUARY Surface SEDIMENTS Global climate and environmental change Water dynamics COASTAL zone GEOLOGICAL survey engineering Qingdao Shandong Province China
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Microstructure and finite element analysis of hot continuous rolling of doped tungsten rod 预览
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作者 Zheng-jie Shao Hai-po Liu +5 位作者 Xiao-chun He Bing Zhou Yang Li Shang-zhou Zhang Meng-jin Li Shu-jun Li 《矿物冶金与材料学报:英文版》 SCIE EI CAS CSCD 2019年第3期369-376,共8页
The microstructures of doped tungsten deformed by multi-pass hot continuous rolling were investigated, and the stress and strain fields were simulated by finite element (FE) method. After the continuous rolling, the g... The microstructures of doped tungsten deformed by multi-pass hot continuous rolling were investigated, and the stress and strain fields were simulated by finite element (FE) method. After the continuous rolling, the grains of the tungsten rod were refined, and the microhardness was improved;however, a ring region of abnormal grain growth was present at a distance of about 3/5R (R is the radius of the rod) from the center of the cross section. FE modeling results showed that the equivalent residual strains were minimum around the region of abnormal grain growth;this was due to the release of strain energy by severe plastic deformation, leading a situation where the migration force of grain boundaries was higher than the pinning force of potassium bubbles. By decreasing the initial rolling temperature and rolling speeds, the inhomogeneity of the equivalent residual stain decreased, improving the microstructure uniformity of the doped tungsten. 展开更多
关键词 DOPED TUNGSTEN continuous ROLLING MICROSTRUCTURE finite element analysis EQUIVALENT RESIDUAL strain
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Changes in neurological and pathological outcomes in a modified rat spinal cord injury model with closed canal 预览
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作者 Xin Sun Xin Sun +5 位作者 Xing-Zhen Liu Jia Wang Hai-Rong Tao Tong Zhu Wen-Jie Jin Kang-Ping Shen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期697-704,共8页
Most animal spinal cord injury models involve a laminectomy,such as the weight drop model or the transection model.However,in clinical practice,many patients undergo spinal cord injury while maintaining a relatively c... Most animal spinal cord injury models involve a laminectomy,such as the weight drop model or the transection model.However,in clinical practice,many patients undergo spinal cord injury while maintaining a relatively complete spinal canal.Thus,open spinal cord injury models often do not simulate real injuries,and few previous studies have investigated whether having a closed spinal canal after a primary spinal cord injury may influence secondary processes.Therefore,we aimed to assess the differences in neurological dysfunction and pathological changes between rat spinal cord injury models with closed and open spinal canals.Sprague-Dawley rats were randomly divided into three groups.In the sham group,the tunnel was expanded only,without inserting a screw into the spinal canal.In the spinal cord injury with open canal group,a screw was inserted into the spinal canal to cause spinal cord injury for 5 minutes,and then the screw was pulled out,leaving a hole in the vertebral plate.In the spinal cord injury with closed canal group,after inserting a screw into the spinal canal for 5 minutes,the screw was pulled out by approximately 1.5 mm and the flat end of the screw remained in the hole in the vertebral plate so that the spinal canal remained closed;this group was the modified model,which used a screw both to compress the spinal cord and to seal the spinal canal.At 7 days post-operation,the Basso-Beattie-Bresnahan scale was used to measure changes in neurological outcomes.Hematoxylin-eosin staining was used to assess histopathology.To evaluate the degree of local secondary hypoxia,immunohistochemical staining and western blot assays were applied to detect the expression of hypoxia-inducible factor 1α(HIF-1α)and vascular endothelial growth factor(VEGF).Compared with the spinal cord injury with open canal group,in the closed canal group the Basso-Beattie-Bresnahan scores were lower,cell morphology was more irregular,the percentage of morphologically normal neurons was lower,the percentages of HIF-1α-and VEGF-immunorea 展开更多
关键词 Basso-Beattie-Bresnahan scores closed spinal canal HIF-1α hypoxia MODEL nerve regeneration open spinal canal rat secondary injury spinal cord injury VEGF
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An effective framework for asynchronous incremental graph processing
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作者 Xinqiao LV Wei XIAO +3 位作者 Yu ZHANG Xiaofei LIAO Hai JIN Qiangsheng HUA 《中国计算机科学前沿:英文版》 SCIE EI CSCD 2019年第3期539-551,共13页
Although many graph processing systems have been proposed, graphs in the real-world are often dynamic. It is important to keep the results of graph computation up-todate. Incremental computation is demonstrated to be ... Although many graph processing systems have been proposed, graphs in the real-world are often dynamic. It is important to keep the results of graph computation up-todate. Incremental computation is demonstrated to be an efficient solution to update calculated results. Recently, many incremental graph processing systems have been proposed to handle dynamic graphs in an asynchronous way and are able to achieve better performance than those processed in a synchronous way. However, these solutions still suffer from sub-optimal convergence speed due to their slow propagation of important vertex state (important to convergence speed) and poor locality. In order to solve these problems, we propose a novel graph processing framework. It introduces a dynamic partition method to gather the important vertices for high locality, and then uses a priority-based scheduling algorithm to assign them with a higher priority for an effective processing order. By such means, it is able to reduce the number of updates and increase the locality, thereby reducing the convergence time. Experimental results show that our method reduces the number of updates by 30%, and reduces the total execution time by 35%, compared with state-of-the-art systems. 展开更多
关键词 INCREMENTAL COMPUTATION GRAPH processing ITERATIVE COMPUTATION ASYNCHRONOUS CONVERGENCE
Predictive value of the Chinese group on the study of severe hepatitis B-acute-on-chronic liver failure score in the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure
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作者 Jing-Jing Tong Wei Zhao +7 位作者 Xiu-Ying Mu Xiang Xu Hai-Bin Su Xiao-Yan Liu Jing Chen Xing-Ran Zhai Yu Wang Jin-Hua Hu 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第13期1541-1549,共9页
Background:As a large,prospective,multicenter study-based prognostic score for hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF),the Chinese group on the study of severe hepatitis B-acute-on-chronic l... Background:As a large,prospective,multicenter study-based prognostic score for hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF),the Chinese group on the study of severe hepatitis B-acute-on-chronic liver failure score(COSSH-ACLFs),has been approved by some foreign scholars;however,its predictive value needs to be verified.This study investigated the predictive value of COSSH-ACLFs for short-term prognosis in Chinese patients with HBV-ACLF.Methods:This retrospective cohort study included 751 patients with HBV-ACLF admitted to the Fifth Medical Center of Chinese PLA General Hospital between January 2011 and December 2014.Spearman method was used to assess the correlation of COSSHACLFs with classical scores.Different COX multivariate regression models were used to confirm the relationship between COSSHACLFs and short-term prognosis in patients with HBV-ACLF,and stratified analysis was used to further verify the stability of this relationship.We compared the predictive powers of COSSH-ACLFs and other classical scores using area under the receiver operating characteristic curve(AUROC)and Z-test.Results:A total of 975 patients with HBV-ACLF were screened,and 751 were analyzed(623 male and 128 female).COSSH-ACLFs was the highest in patients with end-stage ACLF,followed by those with middle-and early-stage ACLF(H=211.8,P<0.001).In the fully adjusted model,COX multivariate regression analysis revealed that COSSH-ACLFs(as a continuous variable)was independently and positively correlated with mortality risk in patients with HBV-ACLF at 28 days(hazard ratio[HR]:1.37[1.22,1.53],P<0.001)and 90 days(HR:1.43[1.29,1.58],P<0.001).The same trend could be observed in the crude model and minimally adjusted model.The AUROCs of COSSH-ACLFs for 28-day and 90-day prognoses in patients with HBV-ACLF were 0.807 and 0.792,respectively,indicating a stronger predictive accuracy than those of classic models.Conclusions:COSSH-ACLFs,with a superior predictive accuracy compared with other classical scores,can strongly predict sh 展开更多
关键词 Hepatitis B virus-related acute-on-chronic liver failure COSSH-ACLF SCORE PREDICTIVE value Prognosis
远海岛礁医院血液保障模式实践与评价
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作者 张蓉 成海 +3 位作者 靳冰 王燕菊 张立萍 蒋学兵 《中国输血杂志》 CAS 2019年第8期740-742,共3页
目的总结远海岛礁医院血液保障的经验做法,探索远海岛礁医院适宜的血液保障模式。方法回顾远海岛礁医院血液保障的实践做法,建立了后方支援保障与'流动血库'相结合的血液保障模式。结果 2种血液保障模式不仅可以满足驻岛军民、... 目的总结远海岛礁医院血液保障的经验做法,探索远海岛礁医院适宜的血液保障模式。方法回顾远海岛礁医院血液保障的实践做法,建立了后方支援保障与'流动血库'相结合的血液保障模式。结果 2种血液保障模式不仅可以满足驻岛军民、过往舰船人员及周边海域作业者的常规医疗用血需求,而且对平时突发事件的血液需求也有一定的保障能力。结论虽然2种血液保障模式可以满足少量常规医疗用血需求,但遇大量用血及批量伤员时则存在一定困难,建立冰冻红细胞储备为基础储备的保障模式是未来血液保障的理想选择。 展开更多
关键词 远海 岛礁医院 血液保障模式
远海岛礁医院冰冻红细胞储备库建设模式探讨
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作者 成海 靳冰 +2 位作者 张蓉 王燕菊 蒋学兵 《中国输血杂志》 CAS 2019年第8期745-747,共3页
目的为满足远海岛礁医院血液保障工作的需要,探讨建立远海岛礁医院冰冻红细胞储备库的保障模式。方法通过对远海岛礁医院冰冻红细胞储备库的必要性和可行性研究,根据远海岛礁医院血液保障特点,提出建设岛礁医院冰冻红细胞储备库的基本... 目的为满足远海岛礁医院血液保障工作的需要,探讨建立远海岛礁医院冰冻红细胞储备库的保障模式。方法通过对远海岛礁医院冰冻红细胞储备库的必要性和可行性研究,根据远海岛礁医院血液保障特点,提出建设岛礁医院冰冻红细胞储备库的基本模式。结果远海岛礁医院现行血液保障模式存在一定的局限性,建立冰冻红细胞储备库可显著提高血液保障能力。结论为满足远海岛礁医院血液保障需求,建立冰冻红细胞储备库是一种行之有效的措施。 展开更多
关键词 远海 岛礁医院 血液保障 冰冻红细胞储备库
柴胡皂甙D通过调控TGF-β1/Smads信号通路抑制人胚肺成纤维细胞增殖和胶原蛋白产生
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作者 孙金玲 郑金旭 +3 位作者 史小东 钱海 金承基 徐莉莉 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2019年第3期256-261,共6页
目的研究柴胡皂甙D(SSD)对转化生长因子β1(TGF-β1)诱导的人胚肺成纤维细胞(HELF)增殖、转分化以及TGF-β1/果蝇抗生物皮肤生长因子蛋白家族(Smads)信号通路的影响。方法体外培养HELF,设立正常对照组、 1 ng/mL TGF-β1处理组、 1 ng/m... 目的研究柴胡皂甙D(SSD)对转化生长因子β1(TGF-β1)诱导的人胚肺成纤维细胞(HELF)增殖、转分化以及TGF-β1/果蝇抗生物皮肤生长因子蛋白家族(Smads)信号通路的影响。方法体外培养HELF,设立正常对照组、 1 ng/mL TGF-β1处理组、 1 ng/mL TGF-β1联合0.5μmol/L SSD处理组、 1 ng/mL TGF-β1联合1μmol/L SSD处理组、 1 ng/mL TGF-β1联合2μmol/L SSD处理组。采用CCK-8法检测HELF的增殖情况,荧光定量PCR法检测Smad2、 Smad3、 Smad7的mRNA水平, Western blot法检测α平滑肌肌动蛋白(α-SMA)、 1型胶原蛋白(Col1)、 Smad2、 Smad3、磷酸化的Smad2(p-Smad2)、 p-Smad3、 Smad7的蛋白水平。结果与正常对照组比较, TGF-β1处理组细胞增殖明显, Col1、α-SMA蛋白水平增加, Smad2和Smad3 mRNA和蛋白磷酸化水平显著增加, Smad7 mRNA和蛋白水平显著降低;与TGF-β1处理组比较,不同浓度SSD处理组细胞增殖降低,可逆转以上各指标的改变,呈一定的量效关系。结论 SSD通过调控TGF-β1/Smads信号通路,发挥抗肺纤维化的作用。 展开更多
关键词 柴胡皂甙D 人胚肺成纤维细胞(HELF) 转化生长因子β1(TGF-β1) 果蝇抗生物皮肤生长因子蛋白(Smads)
Rhabdomyolysis and respiratory insufficiency due to the common ETFDH mutation of c.250G>A in two patients with late-onset multiple acyl-CoA dehydrogenase deficiency
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作者 Hai-Zhu Chen Ming Jin +8 位作者 Nai-Qing Cai Xiao-Dan Lin Xin-Yi Liu Liu-Qing Xu Min-Ting Lin Feng Lin Ning Wang Zhi-Qiang Wang Guo-Rong Xu 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第13期1615-1618,共4页
To the Editor:Late-onset multiple acyl-CoA dehydrogenase deficiency(MADD)is clinically characterized by a fluctuating or progressive proximal myopathy,exercise intolerance but good responsive to riboflavin.ETFDH mutat... To the Editor:Late-onset multiple acyl-CoA dehydrogenase deficiency(MADD)is clinically characterized by a fluctuating or progressive proximal myopathy,exercise intolerance but good responsive to riboflavin.ETFDH mutations are a major cause of late-onset MADD.We analyzed the clinical course,biochemical studies,and muscle magnetic resonance imaging(MRI)and pathologies of two late-onset MADD adult male patients who were misdiagnosed as polymyositis and presented with serious clinical symptoms of rhabdomyolysis and respiratory insufficient after using large dosage of intravenous glucocorticoids.Our current report broadens the clinical phenotypes spectrum of MADD and reminds clinicians to be cautious about using large dosage glucocorticoids in metabolic compromised patients. 展开更多
关键词 RHABDOMYOLYSIS RESPIRATORY INSUFFICIENCY DOSAGE of INTRAVENOUS
环境因素对黄芪产量和品质的影响 预览
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作者 孙海 金桥 +2 位作者 吴虎平 邵财 张亚玉 《特产研究》 2019年第3期118-122,共5页
就生态因子和人为因素对黄芪形态特征、无机养分吸收、重金属离子富集、化学成分、病虫害防治及种植方式等对黄芪产量和品质的影响进行综述,解析造成其影响的原因及其解决方案和建议,拟为黄芪的系统生长发育与个体分布、生态环境与营养... 就生态因子和人为因素对黄芪形态特征、无机养分吸收、重金属离子富集、化学成分、病虫害防治及种植方式等对黄芪产量和品质的影响进行综述,解析造成其影响的原因及其解决方案和建议,拟为黄芪的系统生长发育与个体分布、生态环境与营养吸收规律等相关性研究提供参考。 展开更多
关键词 生态因子 人为因素 黄芪 产量 品质
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