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Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis 预览
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作者 Hiroki Sato Nao Nakajima +9 位作者 Kazuya Takahashi Go Hasegawa Ken-ichi Mizuno Satoru Hashimoto Satoshi Ikarashi Kazunao Hayashi Yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第13期2414-2423,共10页
AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic eso... AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples.RESULTS In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo E.CONCLUSION Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs. 展开更多
关键词 嗜曙红的食道炎 嗜曙红的食道的肌炎 Peroral 内视镜的肌切开术 手提钻食管 ACHALASIA Peroral 食道的肌肉活体检视
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Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers 预览
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作者 Kazuya Takahashi Yuichi Sato +5 位作者 Junji Kohisa Jun Watanabe Hiroki Sato Kenichi Mizuno Satoru Hashimoto Shuji Terai 《世界胃肠内镜杂志:英文版(电子版)》 2016年第19期716-722,
AIM To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection(ESD).METHODS Data were obtained from a total of 26 patients.Fourteen patients were random... AIM To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection(ESD).METHODS Data were obtained from a total of 26 patients.Fourteen patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole group.Patients were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after ESD.Endoscopic images just after ESD,on day 8,and on day 28 were used for the evaluation of the shrinking rate of ESD ulcers.The shrinking rates and the incidence of delayed bleeding were compared between the 2 groups.RESULTS The shrinking rates of ESD ulcers on day 8 [vonoprazangroup: 61.8%(range: 24.0%-91.1%),lansoprazole group: 71.3%(range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3%(range: 76.2%-100%),lansoprazole group: 97.2%(range: 81.1%-99.8%)] were not statistically different between the 2 groups.On day 28,most of the ulcers in both groups healed to more than 90%,whereas 3 of 14(21.4%) in the vonoprazan group and 1 of 12(8.3%) in the lansoprazole group had delayed ulcer healing,which was not statistically different(P = 0.356).The frequency of delayed bleeding was 0 in the both groups.Taken together,there were no significant differences between the two drug groups.CONCLUSION Our study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective. 展开更多
关键词 LANSOPRAZOLE 胃的癌症 内视镜的 submucosal 解剖 钾竞争的酸 blocker 质子泵禁止者 Vonoprazan
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Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis 预览
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作者 Mikihiro Fujiya Hiroki Sato +11 位作者 Nobuhiro Ueno Aki Sakatani Kazuyuki Tanaka Tatsuya Dokoshi Shugo Fujibayashi Yoshiki Nomura Shin Kashima Takuma Gotoh Junpei Sasajima Kentaro Moriichi Jiro Watari Yutaka Kohgo 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第23期5436-5444,共9页
AIM: To compare previously reported randomized controlled studies(RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse... AIM: To compare previously reported randomized controlled studies(RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse events.METHODS: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords 'cold polypectomy'. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients’ demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication bias.RESULTS: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size(less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy group.CONCLUSION: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy. 展开更多
关键词 COLD POLYPECTOMY HOT POLYPECTOMY COLON ADENOMA Conventional POLYPECTOMY COLON NEOPLASM Endoscopic mu
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Microvasculature of the esophagus and gastroesophageal junction: Lesson learned from submucosal endoscopy 预览
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作者 Roberta Maselli Haruhiro Inoue +6 位作者 Haruo Ikeda Manabu Onimaru Akira Yoshida Esperanza Grace Santi Hiroki Sato Bu'Hussain Hayee Shin-Ei Kudo 《世界胃肠内镜杂志:英文版(电子版)》 2016年第19期690-696,
Advanced therapeutic endoscopy,in particular endoscopic mucosal resection,endoscopic submucosal dissection,per-oral endoscopic myotomy,submucosal endoscopic tumor resection opened a new era where direct esophageal vis... Advanced therapeutic endoscopy,in particular endoscopic mucosal resection,endoscopic submucosal dissection,per-oral endoscopic myotomy,submucosal endoscopic tumor resection opened a new era where direct esophageal visualization is possible.Combining these information with advanced diagnostic endoscopy,the esophagus is organized,from the luminal side to outside,into five layers(epithelium,lamina propria with lamina muscularis mucosa,submucosa,muscle layer,adventitia).A specific vascular system belonging to each layer is thus visible: Mucosa with the intra papillary capillary loop in the epithelium and the sub-epithelial capillary network in the lamina propria and,at the lower esophageal sphincter(LES) level with the palisade vessels; submucosa with the drainage vessels and the spindle veins at LES level; muscle layer with the perforating vessels; periesophageal veins in adventitia.These structures are particularly important to define endoscopic landmark for the gastro-esophageal junction,helpful in performing submucosal therapeutic endoscopy. 展开更多
关键词 微脉管系统 食道的解剖 Submucosal 内视镜检查法 每口头的内视镜的肌切开术 先进成像
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Endoscopic features of early-stage signet-ring-cellcarcinoma of the stomach 预览 被引量:1
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作者 Chainarong Phalanusitthepha Kevin L Grimes +4 位作者 Haruo Ikeda Hiroki Sato Chiaki Sato Chananya Hokierti Haruhiro Inoue 《世界胃肠内镜杂志:英文版(电子版)》 2015年第7期741-746,共6页
瞄准:为了识别早图章的特征,包围房间有狭窄的乐队成像(NBI ) 的胃的癌使用放大内视镜检查法。
关键词 图章戒指房间 早胃的癌症 放大内视镜检查法 缩小乐队成像 段符号 内视镜的 submucosal 解剖
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In vivo gastric mucosal histopathology using endocytoscopy 预览
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作者 Hiroki Sato, Haruhiro Inoue, Haruo Ikeda, Chiaki Sato, Chainarong Phlanusittepha, Bu #x02019 Hussain Hayee, Esperanza Grace R Santi, Yasutoshi Kobayashi, and Shin-ei Kudo 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2015年第16期5002-5008,共7页
AIM To study the ability of endocytoscopy to identifynormal gastric mucosa and to exclude Helicobacterpylori (H. pylori ) infection.METHODS: Endocytoscopic examination of the gastriccorpus and antrum was performed ... AIM To study the ability of endocytoscopy to identifynormal gastric mucosa and to exclude Helicobacterpylori (H. pylori ) infection.METHODS: Endocytoscopic examination of the gastriccorpus and antrum was performed in 70 consecutivepatients. Target biopsy specimens were also obtainedfrom the assessed region and multiple H. pylori testswere performed. The normal endocytoscopy patternsof the corpus and antrum were divided into thenormal pit-dominant type (n-Pit) or the normal papilladominanttype (n-Pap), respectively characterized aseither regular pits with capillary networks or round,smooth papillary structures with spiral capillaries. Onthe other hand, normal mucosa was defined as mucosanot demonstrating histological abnormalities, includinginflammation and atrophy.RESULTS: The sensitivity and specificity of n-Pit fornormal mucosa in the gastric corpus were 94.4%and 97.1%, respectively, whereas those of n-Pap fornormal mucosa in the antrum were 92.0% and 86.7%,respectively. The positive predictive values of n-Pitand n-Pap for H. pylori -negative tissue were 88.6%and 93.1%, respectively, and their negative predictivevalues for H. pylori -negative tissues were 42.9% and41.5%, respectively. The inter-observer agreement fordetermining n-Pit and n-Pap for normal mucosa were0.857 and 0.769, respectively, which is consideredreliable.CONCLUSION: N-Pit and n-Pap, seen using EC, are absence of H. pylori infection. 展开更多
关键词 ATROPHY ENDOCYTOSCOPY Gastric MUCOSA HELICOBACTER PYLORI In vivo HISTOPATHOLOGY
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