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Comparison of endoscopic ultrasound, computed tomography and magnetic resonance imaging in assessment of detailed structures of pancreatic cystic neoplasms 预览
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作者 Chen Du Ning-Li Chai +6 位作者 En-Qiang Linghu Hui-Kai Li Li-Hua Sun Lei Jiang Xiang-Dong Wang Ping Tang Jing Yang 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第17期3184-3192,共9页
AIM To evaluate the advantages of endoscopic ultrasound(EUS) in the assessment of detailed structures of pancreatic cystic neoplasms(PCNs) compared to computed tomography(CT) and magnetic resonance imaging(MRI).METHOD... AIM To evaluate the advantages of endoscopic ultrasound(EUS) in the assessment of detailed structures of pancreatic cystic neoplasms(PCNs) compared to computed tomography(CT) and magnetic resonance imaging(MRI).METHODS All patients with indeterminate PCNs underwent CT, MRI, and EUS. The detailed information, including size, number, the presence of a papilla/nodule, the presence of a septum, and the morphology of the pancreatic duct of PCNs were compared among the three imaging modalities. The size of each PCN was determined using the largest diameter measured. A cyst consisting of several small cysts was referred to as a motherdaughter cyst. Disagreement among the three imaging modalities regarding the total number of mother cysts resulted in the assumption that the correct number was the one in which the majority of imaging modalities indicated.RESULTS A total of 52 females and 16 males were evaluated. The median size of the cysts was 42.5 mm by EUS, 42.0 mm by CT and 38.0 mm by MRI; there was no significant difference in size as assessed among the three imaging techniques. The diagnostic sensitivity and ability of EUS to classify PCNs were 98.5%(67/68) and 92.6%(63/68), respectively. These percentages were higher than those of CT(73.1%, P < 0.001; 17.1%, P < 0.001) and MRI(81.3%, P = 0.001; 20.3%, P < 0.001). EUS was also able to better assess the number of daughter cysts in mother cysts than CT(P = 0.003); however, there was no significant difference between EUS and MRI in assessing mother-daughter cysts(P = 0.254). The papilla/nodule detection rate by EUS was 35.3%(24/68), much higher than those by CT(5.8%, 3/52) and MRI(6.3%, 4/64). The detection rate of the septum by EUS was 60.3%(41/68), which was higher than those by CT(34.6%, 18/52) and by MRI(46.9%, 30/64); the difference between EUS and CT was significant(P = 0.02). The rate of visualizing the pancreatic duct using EUS was 100%, whereas using CT and MRI it was less than 10%.CONCLUSION EUS helps visualize the detailed structures of PCNs and has many adv 展开更多
关键词 内视镜的超声 详细结构 计算断层摄影术 磁性的回声成像 胰腺的膀胱的瘤
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Incidents and adverse events of endoscopic ultrasoundguided fine-needle aspiration for pancreatic cystic lesions 预览
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作者 Chen Du Ning-Li Chai +6 位作者 En-Qiang Linghu Hui-Kai Li Yu-Fa Sun Wei Xu Xiang-Dong Wang Ping Tang Jing Yang 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第30期5610-5618,共9页
AIM To evaluate the diagnostic value and safety mainly regarding incidents of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) for pancreatic cystic lesions(PCLs).METHODS A total of 150 consecutive patient... AIM To evaluate the diagnostic value and safety mainly regarding incidents of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) for pancreatic cystic lesions(PCLs).METHODS A total of 150 consecutive patients with suspected PCLs were prospectively enrolled from April 2015 to November 2016. We finally enrolled 140 patients undergoing EUS-FNA. We compared the diagnostic accuracy of EUS-FNA and pathological diagnosis, which is regarded as the gold standard, for PCLs. Patients undergoing EUS-FNA at least 1 wk preoperatively were monitored for incidents and adverse events to evaluate its safety.RESULTS There were 88(62.9%) women and 52(37.1%) men among 140 patients, with a mean age of 50.1(± 15.4) years. There were 67 cysts located in the head/uncinate of the pancreas and 67 in the body/tail, and 6 patients had at least 1 cyst in the pancreas. There were 75 patients undergoing surgery and 55 undergoing EUS-FNA with interval at least 1 wk before other operations, with 3 patients undergoing the procedure twice. The accuracy of EUS-FNA in differentiating benign and malignant lesions was 97.3%(73/75), while the accuracy of characterizing PCL subtype was 84.0%(63/75). The incident rate was 37.9%(22/58), whereas only 1 AE was observed in 58 cases.CONCLUSION EUS-FNA is effective and safe for diagnosis of PCLs, however procedure-related incidents are common. Caution should be taken in patients undergoing EUSFNA. 展开更多
关键词 内视镜的超声 事件 好针的渴望 胰腺的膀胱的损害
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Ling classification describes endoscopic progressive process of achalasia and successful peroral endoscopy myotomy prevents endoscopic progression of achalasia 预览
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作者 Wen-Gang Zhang En-Qiang Linghu +1 位作者 Ning-Li Chai Hui-Kai Li 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第18期3309-3314,共6页
AIM To verify the hypothesis that the Ling classification describes the endoscopic progressive process of achalasia and determine the ability of successful peroral endoscopic myotomy(POEM) to prevent endoscopic progre... AIM To verify the hypothesis that the Ling classification describes the endoscopic progressive process of achalasia and determine the ability of successful peroral endoscopic myotomy(POEM) to prevent endoscopic progression of achalasia.METHODS We retrospectively reviewed the endoscopic findings, symptom duration, and manometric data in patients with achalasia. A total of 359 patients(197 women, 162 men) with a mean age of 42.1 years(range, 12-75 years) were evaluated. Symptom duration ranged from 2 to 360 mo, with a median of 36 mo. Patients were classified with Ling type Ⅰ(n = 119), Ⅱa(n = 106), Ⅱb(n = 60), Ⅱc(n = 60), or Ⅲ(n = 14), according to the Ling classification. Of the 359 patients, 349 underwent POEM, among whom 21 had an endoscopic follow-up for more than 2 years. Pre-treatment and post-treatment Ling classifications of these 21 patients were compared.RESULTS Symptom duration increased significantly with increasing Ling classification(from Ⅰ to Ⅲ)(P < 0.05), whereas lower esophageal sphincter pressure decreased with increasing Ling type(from Ⅰ to Ⅲ)(P < 0.05). There was no difference in sex ratio or onset age among the Ling types, although the age at time of diagnosis washigher in Ling types Ⅱc and Ⅲ than in Ling types Ⅰ, Ⅱa, and Ⅱb. Of the 21 patients, 19 underwent highresolution manometry both before and after treatment. The mean preoperative and postoperative lower esophageal sphincter pressure were 34.6 mmH g(range, 15.3-59.4 mm Hg) and 15.0 mm Hg(range, 2.1-21.6 mmH g), respectively, indicating a statistically significant decrease after POEM. All of the 21 patients were treated successfully by POEM(postoperative Eckardt score ≤ 3) and still had the same Ling type during a mean followup period of 37.8 mo(range, 24-51 mo).CONCLUSION The Ling classification represents the endoscopic progressive process of achalasia and may be able to serve as an endoscopic assessment criterion for achalasia. Successful POEM(Eckardt score ≤ 3) seems to have the ability to prevent endosc 展开更多
关键词 石楠分类 ACHALASIA 前进 Peroral 内视镜的肌切开术 内视镜检查法
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Fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy: A retrospective study at a single center 预览
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作者 Wen-Gang Zhang En-Qiang Linghu Hui-Kai Li 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第9期1637-1644,共8页
AIM To assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy(POEM).METHODS Twenty-four patients who underwent POEM and experienced mucosal ... AIM To assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy(POEM).METHODS Twenty-four patients who underwent POEM and experienced mucosal injury of the cardia during the procedure were retrospectively identified. Of the 24 patients, 21 had mucosal penetration and 3 had only slight mucosal damage without penetration. The 21 patients with mucosal penetration received fibrin sealant for closure at the site of penetration. Penetration-related characteristics, treatment, and recovery were reviewed for all 21 patients to assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia. Clinical data, including general characteristics, procedure-related parameters, Eckardt scores, lower esophageal sphincter pressures (LESP), and esophagogastroduodenoscopy(EGD) results, were analyzed to determine their influence on treatment success after mucosal penetration during POEM.RESULTS All 21 patients had a solitary mucosal penetration in the cardia (12 in esophageal region of the cardia, 9 in the stomach region of the cardia, and 1 in both the esophageal and stomach regions). Twelve had ahole-like penetration and 9 had a linear penetration. For those with a hole-like penetration, the mean size was 0.14 cm2 (0.02-0.32 cm2). For those with a linear penetration, the median size was 0.37 cm (0.10-1.00 cm). Closure of the mucosal penetration using fibrin sealant was performed successfully in all 21 patients(two patients required 5 m L fibrin sealant, and the remaining 19 patients required 2.5 mL). Two patients had a nasogastric tube placed for five days after POEM; the remaining 19 patients were kept fasting for 3 d. All 21 patients were discharged after a median of 5 d(range: 5-7 d) postoperatively. During a median 42 mo (range: 9-62 mo) follow-up, all 21 patients with a mucosal penetration successfully healed without the occurrence of infection, ulcer, or esophagitis. Furthermore, the median LESP decreased from 31.9 mm H 展开更多
关键词 血纤维蛋白密封剂 Mucosal 穿入 Peroral 内视镜的肌切开术 功效 安全
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Endoscopic submucosal tunnel dissection for largesuperficial esophageal squamous cell neoplasms 预览
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作者 Zhai, Ya-Qi Li, Hui-Kai Linghu, En-Qiang 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第1期435-445,共11页
Endoscopic submucosal dissection (ESD) is a wellestablishedtreatment for superficial esophagealsquamous cell neoplasms (SESCNs) with no risk oflymphatic metastasis. However, for large SESCNs,especially when exceed... Endoscopic submucosal dissection (ESD) is a wellestablishedtreatment for superficial esophagealsquamous cell neoplasms (SESCNs) with no risk oflymphatic metastasis. However, for large SESCNs,especially when exceeding two-thirds of the esophagealcircumference, conventional ESD is time-consuming andhas an increased risk of adverse events. Based on thesubmucosal tunnel conception, endoscopic submucosaltunnel dissection (ESTD) was first introduced by us toremove large SESCNs, with excellent results. Studiesfrom different centers also reported favorable results.Compared with conventional ESD, ESTD has a morerapid dissection speed and R0 resection rate. Currentlyin China, ESTD for large SESCNs is an importantpart of the digestive endoscopic tunnel technique,as is peroral endoscopic myotomy for achalasiaand submucosal tunnel endoscopic resection forsubmucosal tumors of the muscularis propria. However,not all patients with SESCNs are candidates for ESTD,and postoperative esophageal strictures should alsobe taken into consideration, especially for lesionswith a circumference greater than three-quarters. Inthis article, we describe our experience, review theliterature of ESTD, and provide detailed informationon indications, standard procedures, outcomes, andcomplications of ESTD. 展开更多
关键词 ENDOSCOPIC SUBMUCOSAL TUNNEL DISSECTION ESOPHAGEAL SQUAMOUS cell neoplasms Digestiveendoscopic TUNNEL technique ENDOSCOPIC submucosaldissection
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Influence of endoscopic submucosal dissection on esophageal motility 预览
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作者 Bao-Guo Bu En-Qiang Linghu +3 位作者 Hui-Kai Li Xiao-Xiao Wang Rong-Bin Guo Li-Hua Peng 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第29期4781-4785,共5页
AIM: To assess esophageal motility after esophageal endoscopic submucosal dissection (ESD). METHODS: Twelve patients (6 men and 6 women) aged 53-64 years (mean age, 58 years) who underwent regular examination 3-12 mo... AIM: To assess esophageal motility after esophageal endoscopic submucosal dissection (ESD). METHODS: Twelve patients (6 men and 6 women) aged 53-64 years (mean age, 58 years) who underwent regular examination 3-12 mo after esophageal ESD for neoplasms of the esophageal body were included in this study. The ESD procedure was performed under deep sedation using a combination of propofol and fentanyl, and involved a submucosal injection to lift the lesion and use of a dual-knife and an insulated-tip knife to create a circumferential incision around the lesion extending into the submucosa. Esophageal motility was examined using a high-resolution manometry system. Dysphagia was graded using a five-point scale according to the Mellow and Pinkas scoring system. Patient symptoms and the results of esophageal manometry were then analyzed. RESULTS: Of the 12 patients enrolled, 1 patient hadgrade 2 dysphagia, 1 patient had grade 1 dysphagia, and 3 patients complained of sporadic dysphagia. Ineffective esophageal motility was observed in 5 of 6 patients with above semi-circumference of resection extension. Of these 5 patients, 1 patient complained of grade 2 dysphagia (with esophageal stricture), one patient complained of grade 1 dysphagia, and 3 patients complained of sporadic dysphagia. Normal esophageal body manometry was observed in all 6 patients with below semi-circumference of resection extension. The 6 patients with normal esophageal motility did not complain of dysphagia. CONCLUSION: Extensive esophageal ESD may cause esophageal dysmotility in some patients, and might also have an influence on dysphagia although without esophageal stricture. 展开更多
关键词 ESOPHAGEAL neoplasm Endoscopic SUBMUCOSAL DISSECTION DYSPHAGIA Ineffective ESOPHAGEAL MOTILITY ESOPHAGEAL MANOMETRY
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New endoscopic classification of achalasia for selection of candidates for peroral endoscopic myotomy 预览 被引量:1
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作者 Hui-Kai Li En-Qiang Linghu 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第4期556-560,共5页
AIM:To propose a new endoscopic classification of achalasia for selecting patients appropriate for undergoing peroral endoscopic myotomy(POEM).METHODS:We screened out the data of patients with achalasia examined from... AIM:To propose a new endoscopic classification of achalasia for selecting patients appropriate for undergoing peroral endoscopic myotomy(POEM).METHODS:We screened out the data of patients with achalasia examined from October 2000 to September 2011 at our Digestive Endoscopic Center with endoscopic pictures clear enough to reveal the morphology of middle and lower esophagus.After analyzing the correlation between the endoscopic morphology of the esophageal lumen and POEM,we proposed a new endoscopic classification(Ling classification) of achalasia according to three kinds of endoscopically viewed structures:multi-ring structure,crescent-like structure and diverticulum structure.There were three types based on the criteria of Ling classification:type Ⅰ,smooth without multi-ring,crescent-like structure or diverticulum structure;type Ⅱ,with multi-ring or crescent-like structure but without diverticulum structure;and type Ⅲ,with diverticulum structure.Type Ⅱ was classified into three subtypes:Ling Ⅱa,Ling Ⅱb and Ling Ⅱc;and type Ⅲ also had three subtypes:Ling Ⅲl,Ling Ⅲr and Ling Ⅲlr.Two endoscopists made a final decision upon mutual agreement through discussion if their separately recorded characteristics were different.RESULTS:Among the 976 screened patients with achalasia,636 patients with qualified endoscopic pictures were selected for the analysis,including 405 males and 231 females.The average age was 42.7 years,ranging from 6 to 93 years.Type Ⅰ was the most commonly observed type of achalasia,accounting for 64.5%(410/636),and type Ⅲ was the least commonly observed type of achalasia,accounting for 2.8%(18/636).And type Ⅱ accounted for 32.7%(208/636) and subtype of Ling Ⅱa,Ling Ⅱb and Ling Ⅱc accounted for 14.6%(93/636),9.9%(63/636) and 8.2%(52/636),respectively.And subtype of Ling Ⅲl,Ling Ⅲr and Ling Ⅲlr accounted for 0.8%(5/636),0.3%(2/636) and 1.7%(11/636),respectively.CONCLUSION:A new endoscopic classification of achalasia is proposed that might help in determining the 展开更多
关键词 ENDOSCOPY CLASSIFICATION ACHALASIA SELECTION Peroral ENDOSCOPIC MYOTOMY
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脑胶质瘤U87-EGFRvIII细胞反义寡核苷酸的^188Re标记实验研究
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作者 齐永帅 黄宝丹 +3 位作者 杜丽 张辉 黄凯 李贵平 《核技术》 CAS CSCD 北大核心 2014年第9期27-32,共6页
研究放射性核素铼^188Re标记脑胶质瘤U87-EGFRvIII(Epidermal Growth Factor Receptor Variant III)细胞反义寡核苷酸序列的制备方法,探讨其作为脑胶质瘤反义显像剂的可能性。采用细胞指数富集的配基系统进化技术(Cell-based Systema... 研究放射性核素铼^188Re标记脑胶质瘤U87-EGFRvIII(Epidermal Growth Factor Receptor Variant III)细胞反义寡核苷酸序列的制备方法,探讨其作为脑胶质瘤反义显像剂的可能性。采用细胞指数富集的配基系统进化技术(Cell-based Systematic Evolution of Ligands by Exponential Enrichment,Cell-SELEX)筛选脑胶质瘤U87-EGFRvIII细胞,得到一段高亲和力的反义寡核苷酸序列U2,然后采用直接标记法进行188Re的放射性标记,按照正交实验设计进行188Re最佳标记条件的摸索,纸层析法测定标记率,通过体外稳定性实验评价188Re-U2的放化特性,测定标记物静脉注射后在大耳兔不同时相血液放射性清除曲线,应用SPECT显像观察标记物在兔体内的放射性动态分布变化。结果表明:在最佳标记条件下188Re-U2的标记率为70%±14%;经Sep-PaK C18反相柱分离纯化后,188Re-U2在生理盐水和血清中37 oC下放置24 h的放化纯度分别为70.6%和95.55%;188Re-U2在兔体内的血放射性清除迅速,主要通过肾脏排泄,其余脏器内放射性均较低。188Re直接法标记U87-EGFRvIII细胞反义寡核苷酸U2的方法简单,具有良好的标记率和体内外稳定性,并且体内分布动力学特性也比较理想。 展开更多
关键词 脑胶质瘤 反义寡脱氧核苷酸 ^188RE 放射性标记
基于多测量技术的零件加工精度在线检测系统 预览 被引量:1
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作者 肖顺旺 安志勇 +3 位作者 史辉 王凯 李丽娟 李升才 《微计算机信息》 2010年第34期24-25,103共3页
为保证零件质量,提出了一种基于多测量技术的零件加工精度在线检测系统。该系统由在线检测路径自动规划子系统、集成接触与非接触式方法的多测量技术在线检测子系统、测量数据处理与评价子系统组成。采取接触式测量与非接触式测量相结... 为保证零件质量,提出了一种基于多测量技术的零件加工精度在线检测系统。该系统由在线检测路径自动规划子系统、集成接触与非接触式方法的多测量技术在线检测子系统、测量数据处理与评价子系统组成。采取接触式测量与非接触式测量相结合的方法,可弥补单种测量方式的不足,提高了检测效率和适用性。 展开更多
关键词 加工精度在线检测 在线检测路径自动规划 多测量技术 测量数据处理
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早期乳腺癌术后背阔肌肌皮瓣联合一期假体置入乳房再造与美学塑形研究 预览 被引量:4
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作者 崔世恩 凌飞海 +3 位作者 黄志华 马士辉 郑书楷 李晓薇 《中国当代医药》 2014年第4期178-180,共3页
目的探讨早期乳腺癌术后背阔肌肌皮瓣联合一期假体置入乳房再造与美学塑形的临床应用效果。方法选取本院2011年12月-2013年10月收治的乳腺癌患者100例。按照知情同意以及自主选择的原则将患者分为对照组和观察组。其中对照组患者进行常... 目的探讨早期乳腺癌术后背阔肌肌皮瓣联合一期假体置入乳房再造与美学塑形的临床应用效果。方法选取本院2011年12月-2013年10月收治的乳腺癌患者100例。按照知情同意以及自主选择的原则将患者分为对照组和观察组。其中对照组患者进行常规乳腺癌改良根治术治疗,而观察组则采用全乳腺切除术及背阔肌肌皮瓣联合一期假体置人乳房再造与美学塑形治疗。观察两组术后并发症、随访生存率、局部复发率、远处转移率,并评价观察组的美学塑形效果。结果观察组患者治疗后,塑形效果总有效率为94.0%。两组术后并发症发生率差异无统计学意义(P〉0.05);两组手术成功率、随访生存率均为100.0%,术后局部复发率以及远处转移率均为0。结论早期乳腺癌术后背阔肌肌皮瓣联合一期假体置入乳房再造与美学塑形是治疗乳腺癌的有效手段,既可以达到治疗乳腺癌的目的.又能够帮助患者维持完美外形,值得临床推广。 展开更多
关键词 乳腺癌 背阔肌皮瓣 假体 乳房再造 美学塑形
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基于形式概念分析的词义理解研究 预览 被引量:1
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作者 杨帆 翟岩慧 +1 位作者 曲开社 李德玉 《计算机科学》 CSCD 北大核心 2011年第B10期 189-191,218,共4页
探讨了形式概念分析在自然语言理解中的多义词分析及义素分析中的应用。在对多义词进行分析时,根据词性与词义之间的二元关系,构造词性与词义的决策背景,进而发现了词性与词义之间的决策规则,并对这些决策规则进行了解释;在对义素分析... 探讨了形式概念分析在自然语言理解中的多义词分析及义素分析中的应用。在对多义词进行分析时,根据词性与词义之间的二元关系,构造词性与词义的决策背景,进而发现了词性与词义之间的决策规则,并对这些决策规则进行了解释;在对义素分析进行研究时,根据语言对象及其语义特征之间的二元关系构造形式背景,并在此背景上分析语言对象,实例表明了形式概念分析既可以很容易地对词语进行分类,又可以很直观地反映词类之间的关系,是进行义素分析的一种有效工具。 展开更多
关键词 形式概念分析 概念格 多义词 义素分析
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基于红外测温的异步电机定子温升传热反计算 预览 被引量:2
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作者 刘慧开 杨立 孙丰瑞 《工程热物理学报》 EI CAS CSCD 北大核心 2006年第z2期 77-80,共4页
现有的检测和诊断方法用于运行中的电机时效果并不理想.本文建立了异步电机定子绕组温升的红外检测传热反问题计算模型,通过使用红外手段监测电机外表面的温升,利用该模型可以计算出定子铁心内部的温升情况,从而可以判断电机的运行是否... 现有的检测和诊断方法用于运行中的电机时效果并不理想.本文建立了异步电机定子绕组温升的红外检测传热反问题计算模型,通过使用红外手段监测电机外表面的温升,利用该模型可以计算出定子铁心内部的温升情况,从而可以判断电机的运行是否正常.计算结果与实验室实测结果进行了分析比较,验证了该模型的可靠性. 展开更多
关键词 异步电机 定子 红外检测 有限体积法
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