期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
MTT Detection of the Toxicity on CdTe Quantum Dots 认领
1
作者 Xiong Su Xiaoyu Gao +9 位作者 Li Jiang Jing Zhang Zhifang Wang Baofeng Chi Hairong Zhang Shibo Bao Ran Zhang Baihui Yun Dejun Sun Juan Sun 《预防医学期刊(英文)》 2021年第1期1-8,共8页
<strong>Objective: </strong>The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with Z... <strong>Objective: </strong>The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with ZnS core quantum dots and CdTe quantum dots modified with Thioglycolic acid or Cysteine functional group (TGA-CdTe, TGA-CdTe/ZnS, Cys-CdTe, Cys-CdTe/ZnS) on Caco-2 cell proliferation. <strong>Methods</strong>: We studied the effect of cell inhibition with ZnS core QDs and CdTe QDs modified with functional group on Caco-2 cell proliferation by MTT assay at 0, 12.5, 25, 50, 100 μg/ml and 6, 24, 48 h. <strong>Result:</strong> Our results showed that all QDs have inhibited cell proliferation and reached maximum 79.21%. The inhibition rate of Cys-modified QDs increased with the increase of concentration and reached maximum 66.72%. The inhibition rate of TGA-modified QDs increased with the increase of time. The ratios of Cys-modified to TGA-modified were less than 1 at all concentrations and three exposure times (P ≤ 0.01). The average ratios of Cys-CdTe/ZnS to Cys-CdTe reached 1.11 only for 48 h (P ≤ 0.05). The ratios of TGA-CdTe/ZnS to TGA-CdTe were closed to 1 at all concentrations and exposure times. <strong>Conclusion:</strong> The regularity of QDs modified with functional group is that inhibition of TGA-modified higher than Cys-modified. Inhibition exhibited dose-dependent for Cys-modified while exhibited time-dependent for TGA-modified. The regularity of CdTe-QDs with ZnS or not is that the inhibition of Cys-CdTe/ZnS was higher than Cys-CdTe while TGA-CdTe/ZnS and TGA-CdTe were consistent. 展开更多
关键词 CdTe Quantum Dots MTT Inhibition Rate
在线阅读 免费下载
上一页 1 下一页 到第
使用帮助 返回顶部 意见反馈