期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Linked PNPLA3 polymorphisms confer susceptibility tononalcoholic steatohepatitis and decreased viral load inchronic hepatitis B 预览 被引量:2
1
作者 Pan, Qin Zhang, Rui-Nan +11 位作者 Wang, Yu-Qin Zheng, Rui-Dan Mi, Yu-Qiang Liu, Wen-Bin Shen, Feng Chen, Guang-Yu Lu, Jia-Fa Zhu, Chan-Yan Zhang, Shu-Yi Chen, Yi-Ming Sun, Wan-Lu Fan, Jian-Gao 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2015年第28期8605-8614,共10页
AIM To investigate the association of PNPLA3polymorphisms with concurrent chronic hepatitis B(CHB) and nonalcoholic fatty liver disease (NAFLD).METHODS: A cohort of Han patients with biopsyprovenCHB, with or with... AIM To investigate the association of PNPLA3polymorphisms with concurrent chronic hepatitis B(CHB) and nonalcoholic fatty liver disease (NAFLD).METHODS: A cohort of Han patients with biopsyprovenCHB, with or without NAFLD (CHB group,n = 51; CHB + NAFLD group, n = 57), and normalcontrols (normal group, n = 47) were recruited fromNorthern (Tianjin), Central (Shanghai), and Southern(Zhangzhou) China. Their PNPLA3 polymorphismswere genotyped by gene sequencing. The associationbetween PNPLA3 polymorphisms and susceptibilityto NAFLD, and clinical characteristics of NAFLD wereevaluated on the basis of physical indices, liver functiontests, glycolipid metabolism, and histopathologicscoring. The association of PNPLA3 polymorphisms andhepatitis B virus (HBV) load was determined by theserum level of HBV DNA.RESULTS: After adjusting for age, sex, and bodymass index, we found that four linked single nucleotidepolymorphisms (SNPs) of PNPLA3 , including thers738409 G allele (CHB + NAFLD group vs CHB group:odds ratio [OR] = 2.77, 95% confidence interval[CI]: 1.18-6.54; P = 0.02), rs3747206 T allele (CHB+ NAFLD group vs CHB group: OR = 2.77, 95%CI:1.18-6.54; P = 0.02), rs4823173 A allele (CHB +NAFLD group vs CHB group: OR = 2.73, 95%CI:1.16-6.44; P = 0.02), and rs2072906 G allele (CHB+ NAFLD group vs CHB group: OR = 3.05, 95%CI:1.28-7.26; P = 0.01), conferred high risk to NAFLD inCHB patients. In patients with both CHB and NAFLD,these genotypes of PNPLA3 polymorphisms wereassociated with increased susceptibility to nonalcoholicsteatohepatitis (NASH) (NAFLD activity score ≥ 3; P =0.01-0.03) and liver fibrosis (〉 1 Metavir grading; P =0.01-0.04). As compared to those with C/C and C/G atrs738409, C/C and C/T at rs3747206, G/G and G/A atrs4823173, and A/A and A/G at rs2072906, patients inthe CHB + NAFLD group with G/G at rs738409, T/T atrs3747206, A/A at rs4823173, and G/G at rs2072906showed significantly lower serum levels of HBV DNA 展开更多
关键词 Chronic HEPATITIS B HEPATITIS B virus NONALCOHOLIC FATTY liver disease PNPLA3 Singlenucleotidepolymorphism
在线阅读 免费下载
一种新的单侧听觉气传导持续阻滞大鼠模型 预览
2
作者 万平 卢静平 《上海实验动物科学》 1998年第2期 85-87,共3页
用外耳道外沿皮下缝合法制备了一种新的单侧听觉气传导的持续阻滞大鼠模型。它具有制作简便,损产小,效果持续的优点。
关键词 听觉 气传导 阻滞 疾病模型 大鼠
在线阅读 下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部 意见反馈