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Effects of the Casimir force on the properties of a hybrid optomechanical system
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作者 王一平 张筑城 +1 位作者 於亚飞 张智明 《中国物理B:英文版》 SCIE EI CAS CSCD 2019年第1期379-384,共6页
We investigate the effects of the Casimir force on the output properties of a hybrid optomechanical system. In this system, a nanosphere is fixed on the movable-mirror side of the standard optomechanical system, and t... We investigate the effects of the Casimir force on the output properties of a hybrid optomechanical system. In this system, a nanosphere is fixed on the movable-mirror side of the standard optomechanical system, and the nanosphere interacts with the movable-mirror via the Casimir force, which depends on the mirror–sphere separation. In the presence of the probe and control fields, we analyze the transmission coefficient and the group delay of the field-component with the frequency of the probe field. We also study the transmission intensity of the field-component with the frequency of a newly generated four-wave mixing(FWM) field. By manipulating the Casimir force, we find that a tunable slow light can be realized for the field-component with the frequency of the probe field, and the intensity spectrum of the FWM field can be enhanced and shifted effectively. 展开更多
关键词 QUANTUM OPTICS OPTOMECHANICS QUANTUM information and PROCESSING
Rapidly counting atomic planes of ultra-thin MoSe2 nanosheets (1 ≤ n ≤ 4) on SiO2/Si substrate
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作者 Yi-Ping Wang Hui-Jun Zhou +4 位作者 Gui-Hua Zhao Tian-Long Xia Lei Wang Le Wang Li-Yuan Zhang 《稀有金属:英文版》 SCIE EI CAS CSCD 2016年第8期632-636,共5页
The optical, thermal and electrical properties of ultra-thin two-dimensional(2D) crystal materials are highly related to their thickness. Therefore, identifying the atomic planes of few-layer crystal materials rapid... The optical, thermal and electrical properties of ultra-thin two-dimensional(2D) crystal materials are highly related to their thickness. Therefore, identifying the atomic planes of few-layer crystal materials rapidly is crucial to fundamental study. Here, a simple technique was demonstrated based on optical contrast for counting atomic planes(n) of few-layer MoSe2 on SiO2/Si substrates. It is found that the optical contrast of single-layer MoSe2 depends on light wavelength and thickness of SiO2 on Si substrate. The data calculated based on a Fresnel law-based model as well as atomic force microscopy(AFM) measurements fit well with the values measured by spectroscopic ellipsometer. Furthermore, the calculated and measured contrasts were integral and plotted, which can be used to determine the MoSe2 atomic planes(1≤n≤4)accurately and rapidly. 展开更多
关键词 SI衬底 SiO2 快速计数 原子 纳米 超薄
Intestinal histoplasmosis in immunocompetent adults 预览
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作者 Lin-Lin Zhu Jin Wang +2 位作者 Zi-Jing Wang Yi-Ping Wang Jin-Lin Yang 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第15期4027-4033,共7页
AIM: To present a retrospective analysis of clinical and endoscopic features of 4 cases of immunocompetent hosts with intestinal histoplasmosis(IH).METHODS: Four immunocompetent adults were diagnosed with IH between O... AIM: To present a retrospective analysis of clinical and endoscopic features of 4 cases of immunocompetent hosts with intestinal histoplasmosis(IH).METHODS: Four immunocompetent adults were diagnosed with IH between October 2005 and March 2015 at West China Hospital of Sichuan University. Clinical and endoscopic characteristics were summarized and analyzed retrospectively. GMS(Gomori methenamine silver), PAS(periodic acid-Schiff) and Giemsa staining technique were used to confirm Histoplasma capsulatum(H. capsulatum). The symptoms, signs, endoscopic presentations, radiographic imaging, pathological stain results and follow-up are presented as tables and illustrations.RESULTS: The cases were male patients, ranging from 33 to 61 years old, and primarily presented with nonspecific symptoms such as irregular fever, weight loss, abdominal pain and distention. Hepatosplenomegaly and lymphadenopathy were the most common signs. Endoscopic manifestations were localized or diffuse congestion, edema, ulcers, and polypoid nodules with central erosion involving the terminal ileum, ascendingcolon, transverse colon, descending colon, sigmoid colon and rectum, similar to intestinal tuberculosis, tumor, and inflammatory bowel disease. Numerous yeast-like pathogens testing positive for PAS and GMS stains but negative for Giemsa were detected in the cytoplasm of the histiocytes, which were highly suggestive of H. capsulatum.CONCLUSION: Immunocompetent individuals suffering from histoplasmosis are rarely reported. It is necessary that gastroenterologists and endoscopists consider histoplasmosis as a differential diagnosis, even in immunocompetent patients. 展开更多
关键词 INTESTINAL HISTOPLASMOSIS DISSEMINATED HISTOPLASMOSIS IMMUNOCOMPETENCE Endoscopic characteristics Di
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High resolution deep imaging of a bright radio quiet QSO at z~3
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作者 Yi-Ping Wang Wei He +3 位作者 Toru Yamada Ichi Tanaka Masanori Iye Tuo Ji 《天文和天体物理学研究:英文版》 SCIE CAS CSCD 2015年第5期673-686,共14页
We have obtained deep J and Ks-band images centered on a bright radio quiet QSO UM 402(zem= 2.856) using the IRCS camera and adaptive optics systems that are part of the Subaru Telescope, as well as retrieved WFC3/F14... We have obtained deep J and Ks-band images centered on a bright radio quiet QSO UM 402(zem= 2.856) using the IRCS camera and adaptive optics systems that are part of the Subaru Telescope, as well as retrieved WFC3/F140 W archive images of this object. A faint galaxy(mk= 23.32 ± 0.05 in the Vega magnitude system)that lies ~ 2.4′′north of the QSO sightline has been clearly resolved in all three deep high resolution datasets, and appears as an irregular galaxy with two close components in the Ks-band images(separation ~ 0.3′′). Given the small impact parameter(b = 19.6 kpc, at zlls= 2.531), as well as the red color of(J- K s)Vega~ 1.6,it might be a candidate galaxy giving rise to the Lyman Limit system absorption at zabs= 2.531 seen in the QSO spectrum. After carefully subtracting the point spread function from the QSO images, the host galaxy of this bright radio quiet QSO at z ~ 3was marginally revealed. We placed a lower limit on the host component of mk~ 23.3according to our analyses. 展开更多
关键词 高分辨率成像 无线电 安静 自适应光学系统 S-波段 点扩散函数 星等系统 冲击参数
New species of gallwasps inducing in Quercus fabri and its inquiline (Hymenoptera: Cynipidae)in China
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作者 Juli Pujade-Villar Yi-Ping Wang +1 位作者 Rui Guo Xue-Xin Chen 《动物分类学报:英文版》 CSCD 北大核心 2014年第3期417-423,共7页
New species of gallwasps, Andricus flavus sp. nov., and its inquiline related to its gall, Saphonecrus fabris sp. nov. are described. Both species are included and illustrated their distribution and biology here. The ... New species of gallwasps, Andricus flavus sp. nov., and its inquiline related to its gall, Saphonecrus fabris sp. nov. are described. Both species are included and illustrated their distribution and biology here. The type materials are deposited in the Parasitic Hymenoptera Collection, Zhejiang Agricultural and Forest University, Lin’an, China, and University of Barcelona Barcelona, Spain. 展开更多
关键词 中国 新品种 膜翅目 白栎 诱导 黄曲霉菌 巴塞罗那 生物学
Taxonomic review of East Palearctic species of Synergus section I, with description of a new species from China (Hymenoptera: Cynipidae: Cynipinae)
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作者 Juli Pujade-Villar Yi-Ping Wang +1 位作者 Xue-Xin Chen Jun-Hua He 《动物分类学报:英文版》 CSCD 北大核心 2014年第4期534-544,共11页
A taxonomic review is provided for the Section I of the inquiline gallwasp genus Synergus, including the description of a new species from China, S. deqingensis Pujade-Villar, Wang & Chen sp. nov. and redescriptio... A taxonomic review is provided for the Section I of the inquiline gallwasp genus Synergus, including the description of a new species from China, S. deqingensis Pujade-Villar, Wang & Chen sp. nov. and redescription of all previously known species of the section from the that region. Synergus jezoensis Uchida & Sakagami, 1948, a species previously considered of uncertain status from Japan, is treated herein as a valid species, and is redescribed and reported for the first time from China. Andricus mukaigawae(Mukaigawa, 1913) and its inquiline, S. japonicus, are reported for the first time from China. A key is provided to all four East Palearctic species in Section I of Synergus. 展开更多
关键词 中国 分类 新品种 膜翅目 评审 新种 物种
Decreased histone H2B monoubiquitination in malignant gastric carcinoma 预览
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作者 Zi-Jing Wang Jing-Lin Yang +4 位作者 Yi-Ping Wang Jiang-Yan Lou Jie Chen Cong Liu Lian-Di Guo 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第44期8099-8107,共9页
AIM:To investigate H2B monoubiquitination(uH2B)and H3K4 di-and tri-methylation(H3K4-2me,H3K4-3me)levels and their clinical significance in gastric cancer(GC).METHODS:Immunohistochemistry(IGC)was used to detect the di... AIM:To investigate H2B monoubiquitination(uH2B)and H3K4 di-and tri-methylation(H3K4-2me,H3K4-3me)levels and their clinical significance in gastric cancer(GC).METHODS:Immunohistochemistry(IGC)was used to detect the differential levels of uH2B,H3K4-2me and H3K4-3me modifications in GC specimens from chemo/radiotherapy-na ve patients who underwent potentially curative surgical resection(n=159)and in a random sampling of non-tumor gastric epithelium specimens(normal controls,n=20).The immunohistochemistry(IHC)-detected modifications were classified as negative,low-level,or high-level using a dual-rated(staining intensity and percentage of positively-stained cells)semi-quantitative method.The relationships between uH2B modification levels and clinicopathological parameters of GC were assessed by a Wilcoxon rank sum test(pairwise comparisons)and the Kruskal-Wallis H test(multiple comparisons).The correlation between uH2B modification and survival was estimated by Kaplan-Meier analysis,and the role of uH2B as an independent prognostic factor for survival was assessed by multivariate Cox regression analysis.RESULTS:The presence and level of H3K4-2me and H3K4-3me IHC staining was similar between the normal controls and GC specimens.In contrast,the level of uH2B was significantly lower in the malignant gastric tissues(vs normal control tissues)and decreased along with increases in dedifferentiation(well differentiated】moderately differentiated】poorly differentiated).The level of uH2B correlated with tumor differentiation(P【0.001),Lauren’s diffuse-and intestinal-type classification(P【0.001),lymph node metastasis(P=0.049)and tumor-node-metastasis stage(P=0.005).Patients with uH2B+staining had higher 5-year survival rates than patients with uH2B-staining(52.692±2.452 vs23.739±5.207,P【0.001).The uH2B level was an independent prognostic factor for cancer-specific survival(95%CI:0.237-0.677,P=0.001).CONCLUSION:uH2B displays differential IHC staining patterns corresponding to progressive stages of GC.uH2B may 展开更多
关键词 Gastric cancer EPIGENETICS HISTONE modification H2B monoubiquination Nuclear IMMUNOSTAINING
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血必净对急性胰腺炎大鼠血清中TNF-α、IL-1β和lL-6浓度的影响 预览 被引量:15
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作者 徐伟松 范辉 +2 位作者 刘玉峰 王一平 李振东 《世界华人消化杂志》 CAS 北大核心 2012年第29期2777-2781,共5页
目的:检测血必净治疗前、后急性胰腺炎(acutepancreatitis,AP)大鼠血清细胞肿瘤坏死因子(tumornecrosisfactor仪,TNF-α)、白细胞介素(interleukin,IL)-1β和IL-6浓度变化、胰腺组织损伤的关系,以探讨血必净缓解AP大鼠炎症... 目的:检测血必净治疗前、后急性胰腺炎(acutepancreatitis,AP)大鼠血清细胞肿瘤坏死因子(tumornecrosisfactor仪,TNF-α)、白细胞介素(interleukin,IL)-1β和IL-6浓度变化、胰腺组织损伤的关系,以探讨血必净缓解AP大鼠炎症反应的可能机制.方法:♂SD大鼠90只分为对照组(A组,n=30),AP组(B组,n=30)和血必净治疗组(C组,n=30);腹腔注射L-精氨酸制造AP大鼠模型,观察模型成功制作后6、12及24h各组大鼠血清细胞因子TNF-α、IL-1β和IL-6浓度变化,采用酶联免疫吸附剂测定(ELIsA)法测定血清细胞因子TNF-α、IL-1β和IL-6的浓度.胰腺组织病理变化并对胰腺组织损伤进行评分.结果:与A组比较,B组大鼠6、12及24h血清TNF-α、IL-1β和IL一6浓度升高,各时间点差异有统计学意义(TNF-α:6h:f=17.72,t=0.00;12h:t=11.19.P:0.00;24h:t=13.70.P=0.00;IL-1β:6h:,=9.6l,t=0.00;12h:,=8.69,P=0.00;24h:t=8.08.P=0.00.IL-6:6h:t:29.18.P=0.00;12h:t=18.59.P=0.00;24h:t=17.14,P=0.00).与B组大鼠6h、12h及24h胰腺病理评分明显升高,各时间点差异有统计学意义f6h:t=17.23,P=0.00;12h:t=18.72,P=0.00;24h:t=16.08,P=0.00).与B组比较,血必净注射液可明显降低C组大鼠12、24h血清TNF-α、IL-1β和IL-6浓度,12、24h组间差异有统计学意义(TNF-α :12h:t=7.56,P=0.001:24h:t=7.30,P=0.00.IL-1β:12h:t=8.76,P=0.00;24h:t=8.07.P=0.00.IL-6:12h:t=7.82.P=0.00;24h:t=6.72,P=0.00):并且明显降低C组24h大鼠胰腺病理评分分值,24h点组间差异有统计学意义(24h:t:2.79,P=0.015).结论:血必净在早期能够降低AP大鼠血清细胞因子TNF-α、IL-1β和IL-6的浓度.通过抑制炎症反应来改善胰腺组织病理损伤,这可能是血必净治疗AP的作用机制之一� 展开更多
关键词 血必净 急性胰腺炎 肿瘤坏死因子-Α IL-1Β 白介素-6
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Involvement of estrogen receptor-β in farrerol inhibition of rat thoracic aorta vascular smooth muscle cell proliferation
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作者 Qun-yi LI Li CHEN +3 位作者 Yan-hui ZHU Meng ZHANG Yi-ping WANG Ming-wei WANG 《中国药理学报:英文版》 SCIE CAS CSCD 2011年第4期433-440,共8页
关键词 血管平滑肌 雌激素受体 细胞增殖 主动脉 大鼠 细胞周期蛋白 诱导培养 DNA合成
Mapping QTLs for Drought Tolerance at Seedling Stage in Rice Using Doubled Haploid Population 预览
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作者 Xu Qun YUAN Xiao-ping Yu Han-yong WANG Yi-ping TANG Sheng-xiang WEI Xing-hua 《水稻科学:英文版》 2011年第1期 23-28,共6页
为在米饭幼苗阶段的干旱忍耐的 QTL 用加倍的 haploid (DH ) 被分析人口从在装饰用的梨树父母 Maybelle 和 indica 父母 Baiyeqiu 之间的十字由 251 根线组成了。有 226 SSR 标记 loci 的一张基因连接地图被构造。跟随合成间隔印射的单... 为在米饭幼苗阶段的干旱忍耐的 QTL 用加倍的 haploid (DH ) 被分析人口从在装饰用的梨树父母 Maybelle 和 indica 父母 Baiyeqiu 之间的十字由 251 根线组成了。有 226 SSR 标记 loci 的一张基因连接地图被构造。跟随合成间隔印射的单个地点的分析(计算机输入缩微胶卷) 检测了位于米饭的五个不同染色体的五 QTL 的一个总数。四 QTL 也被检测跟随二地点的分析,解决二 epistatic QTL (E-QTLs ) 与积极并且添加剂基因效果。结果显示从父母 Baiyeqiu 的等位基因贡献了 DH 人口在幼苗阶段改进干旱忍耐。 展开更多
关键词 QTL分析 双单倍体群体 抗旱性 苗期 水稻 加倍单倍体(DH)群体 复合区间作图法 遗传连锁图谱
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State-dependent blockade of human ether-a-go-go- related gene (hERG) K+ channels by changrolin in stably transfected HEK293 cells
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作者 Wei-hai CHEN Wen-yi WANG +2 位作者 Jie ZHANG Ding YANG Yi-ping WANG 《中国药理学报:英文版》 SCIE CAS CSCD 2010年第8期915-922,共8页
关键词 HEK293细胞 人类胚胎 钾通道 相关基因 稳定表达 状态 全细胞膜片钳技术 封锁
Magnesium lithospermate B dilates mesenteric arteries by activating BKca currents and contracts arteries by inhibiting Kv currents
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作者 Hai-fei ZHANG Xue-qing CHEN Guo-yuan HU Yi-ping WANG 《中国药理学报:英文版》 SCIE CAS CSCD 2010年第6期665-670,共6页
关键词 丹酚酸B 钾电流 肠系膜 钾通道 动脉 激活 镁盐 去甲肾上腺素
清肾颗粒对慢性肾功能衰竭急剧加重湿热证患者血清白细胞介素8和18水平影响的随机对照临床研究 预览 被引量:6
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作者 王飞 王亿平 +4 位作者 王东 程皖 胡顺金 吕勇 刘玲 《中西医结合学报》 CAS 2010年第4期 328-331,共4页
背景:湿热证是慢性肾功能衰竭(chronic renal failure,CRF)急剧加重患者的主要证候表现,清肾汤可减轻患者的临床症状,对急剧恶化的肾功能有一定的逆转作用。目的:观察CRF急剧加重湿热证患者血清白细胞介素8(interleukin-8,IL-8)和... 背景:湿热证是慢性肾功能衰竭(chronic renal failure,CRF)急剧加重患者的主要证候表现,清肾汤可减轻患者的临床症状,对急剧恶化的肾功能有一定的逆转作用。目的:观察CRF急剧加重湿热证患者血清白细胞介素8(interleukin-8,IL-8)和IL-18水平及清肾颗粒的干预作用。设计、场所、对象和干预措施:将60例CRF急剧加重湿热证患者随机分为治疗组和对照组各30例,并选取20名健康体检者作为正常组。CRF患者源自安徽中医学院第一附属医院肾内科。治疗组与对照组均在西药常规治疗的同时使用中药解毒泄浊Ⅱ号保留灌肠,治疗组加用清肾颗粒,每次1袋,3次/d,口服,疗程1个月。主要结局指标:检测治疗组与对照组治疗前后IL-8、IL-18水平变化,并与正常组比较。结果:治疗组临床疗效和中医证候疗效总有效率(86.67%和86.67%)明显高于对照组(56.67%和60%)(P〈0.05)。CRF急剧加重湿热证患者治疗前血清IL-8、IL-18水平明显高于正常组(P〈0.01);两组治疗前血清IL-8、IL-18比较,差异无统计学意义(P〉0.05),治疗后两组血清IL-8和IL-18水平均有所下降(P〈0.01);治疗组治疗前后血清IL-8、IL-18下降程度与对照组比较,差异亦有统计学意义(P〈0.05)。结论:CRF急剧加重湿热证患者血清IL-8、IL-18水平较正常人明显升高,清肾颗粒可降低其水平,改善肾功能,减轻临床症状。 展开更多
关键词 慢性肾功能衰竭 湿热 白细胞介素8 白细胞介素18 中药 随机对照试验
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Inhibitory effects of lithospermic acid on proliferation and migration of rat vascular smooth muscle cells 被引量:1
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作者 Li CHEN Wen-yi WANG Yi-ping WANG 《中国药理学报:英文版》 SCIE CAS CSCD 2009年第9期1245-1252,共8页
关键词 血管平滑肌细胞 草酸 大鼠 迁移 增殖
Effects of scutellarin on PKCγ in PC12 cell injury induced by oxygen and glucose deprivation 被引量:2
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作者 Wei XU Ruo-peng ZHA +1 位作者 Wen-yi WANG Yi-ping WANG 《中国药理学报:英文版》 SCIE CAS CSCD 2007年第10期1573-1579,共7页
瞄准:为了把 neuroprotective 效果和黄岑素(Scu ) 的机制与 PC12 作比较,在氧和葡萄糖剥夺以后的房间损害由灌注(OGD 议员) 列在后面。方法:无差别的老鼠嗜铬细胞瘤 PC12 房间,暴露了到灌注(OGD 议员) 跟随的氧和葡萄糖剥夺,用作 ... 瞄准:为了把 neuroprotective 效果和黄岑素(Scu ) 的机制与 PC12 作比较,在氧和葡萄糖剥夺以后的房间损害由灌注(OGD 议员) 列在后面。方法:无差别的老鼠嗜铬细胞瘤 PC12 房间,暴露了到灌注(OGD 议员) 跟随的氧和葡萄糖剥夺,用作 ischemia/reperfusion 的一个在试管内模型。房间幸存被 diphenyltetrazolium 评估溴化物(MTT ) 试金和 LDH 版本的数量用试金工具包被决定。[Ca2+] 我用荧光灯的 Ca2+ 敏感的染料 Fura-2 acetoxymethyl 酉旨被监视。房间 apoptosis 被一个 DNA 梯子并且由流动 cytometric 察觉检测。蛋白质激酶 C (PKC ) 鲸鱼群妈的表示用 RT-PCR 并且西方的弄污被决定。PKCgamma 的易位是由潜水艇的 assayed 细胞的分别并且西方的弄污。结果:OGD 议员损害显著地提高了 LDH 版本的水平,[Ca2+] 我, mRNA 表示和正常与那些在 PC12 房间作比较的 PKCgamma 的易位组织。Scu (10-100 mumol/L ) 由减少 LDH 版本对 OGD 议员损害施加了保护的效果,[Ca2+] 我, apoptosis 的百分比,和 PKCgamma 的易位。结论:Scu 禁止增加[Ca2+] i 和 PKCgamma 的激活,对 PC12 房间损害施加保护的效果由 OGD 议员导致了。 展开更多
关键词 黄芩素 细胞凋亡 蛋白质
Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry 被引量:1
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作者 Xiao-fen LI Yi-ping WANG 《中国药理学报:英文版》 SCIE CAS CSCD 2007年第6期789-795,共7页
目的:在开胸的使麻木的 Sprague-Dawleyrats.Methods 从鼠尾草植物 miltiorrhiza onmyocardial microperfusion 和全身的 hemodynamics 调查 depside 盐的效果:心肌的 microperfusion 被激光 Doppler flowmetry 与 needleprobe 测量... 目的:在开胸的使麻木的 Sprague-Dawleyrats.Methods 从鼠尾草植物 miltiorrhiza onmyocardial microperfusion 和全身的 hemodynamics 调查 depside 盐的效果:心肌的 microperfusion 被激光 Doppler flowmetry 与 needleprobe 测量;心脏的输出(公司)用超声的 Doppler flowmetry.Other hemodynamicparameters 被决定包括大腿骨的动脉血压,心脏的 inotropy ,并且全身的脉管的抵抗( SVR )被 PowerLab 系统同时记录 展开更多
关键词 缩酚酸盐 鼠尾草 心肌疾病 激光多谱勒检查
Tetrahydroacridine inhibits voltage-dependent Na^+ current in guinea-pig ventricular myocytes
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作者 WeiWANG Yi-pingWANG Guo-yuanHU 《中国药理学报:英文版》 SCIE CAS CSCD 北大核心 2004年第9期 1138-1144,共7页
AIM: To study the effects of tetrahydroacridine (tacrine) on voltage-gated Na^+ channels in cardiac tissues. METHODS: Single ventricular myocytes were enzymatically dissociated from adult guinea-pig heart. Voltage-dep... AIM: To study the effects of tetrahydroacridine (tacrine) on voltage-gated Na^+ channels in cardiac tissues. METHODS: Single ventricular myocytes were enzymatically dissociated from adult guinea-pig heart. Voltage-dependent Na^+ current was recorded using whole cell voltage-clamp technique. RESULTS: (1) Tacrine reversibly inhibited Na^+ current with an IC50 value of 120μmol/L(95% confidence range: 108-133μmol/L). (2) The inhibitory effects of tacrine on Na^+ current exhibited both a tonic nature and use-dependence. (3) Tacrine at 100μmol/L caused a negative shift (about 10mV) in the voltage-dependence of steady-state inactivation of Na^+ current, and retarded its recovery from inactivation, but did not affect its activation curve. (4) Intracellular application of tacrine significantly inhibited Na^+ current. CONCLUSION: In addition to blocking other voltage-gated ion channels,tacrine blocked Na^+ channels in guinea-pig ventricular myocytes. Tacrine acted as inactivation stabilizer of Na^+ channels in cardiac tissues. 展开更多
关键词 四氢鸭脚木碱 抑制作用 电压 NA^+ 心室肌细胞 阿尔海默氏疾病
精氨酸甲基转移酶CARM1通过甲基化苹果酸脱氢酶MDH1降低谷氨酰胺代谢并抑制胰腺癌
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《科学新闻》 2017年第4期95-95,共1页
与正常细胞不同,肿瘤细胞体现出独特的谷氦酰胺依赖性以满足合成代谢过程。值得注意的是,胰腺导管腺癌细胞通过谷草转氰酶、苹果酸脱氢酶MDH1和苹果酸酶催化的非经典代附途径重塑谷氦酰胺代谢以维持还原力NADPH的生成。
关键词 苹果酸脱氢酶 合成代谢 谷氨酰胺 胰腺 精氨酸 癌细胞 依赖性
HRM、24h pH-MII在内镜阴性烧心诊断中的应用研究 预览
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作者 张颖慧 王一平 《中国现代医学杂志》 CAS 2019年第2期58-62,共5页
目的利用高分辨率食管测压(HRM)和24h食管多通道腔内阻抗pH监测(24hpH-MII)探讨内镜阴性烧心患者的食管动力及反流特点。方法选取在四川省医学科学院·四川省人民医院消化内科门诊就诊的以反流症状为主的问卷调查量表(GerdQ)评分&g... 目的利用高分辨率食管测压(HRM)和24h食管多通道腔内阻抗pH监测(24hpH-MII)探讨内镜阴性烧心患者的食管动力及反流特点。方法选取在四川省医学科学院·四川省人民医院消化内科门诊就诊的以反流症状为主的问卷调查量表(GerdQ)评分>8分和胃镜阴性患者303例,分为非糜烂性反流病(NERD)组、高敏感性食管(HE)组及功能性烧心(FH)组。搜集指标:食管远端收缩积分(DCI)、下食管括约肌静息压(LESP)、有效蠕动百分比及食管-胃连接部(EGJ)分型;阻抗基线值、不同性质及性状反流次数及近端反流次数。结果①食管基线阻抗值:NERD组、HE组低于FH组(P<0.05);②酸反流:NERD组DeMeester评分、最长反流时间(AET)、立/卧位AET高于HE组、FH组(P<0.05);③化学及物理反流:NERD组以酸、液体及混合反流为主,HE组以弱酸、液体及混合反流为主,FH组以非酸及气体反流为主;④动力指标:NERD组食管LESP低于HE组、FH组(P<0.05),NERD组和HE组DCI低于FH组(P<0.05),FH组有效蠕动比高于其他两组(P<0.05),NERD组EGJⅡ型比例(29%)多于HE组(9%)、FH组(1%)(P<0.05)。结论①NERD在食管动力及反流事件方面更符合GERD的发病机制;②HE患者较FH在食道动力的减弱及反流事件中增多更明显,FH患者在食道动力及反流方面无明显异常;③食管HRM联合24hpH-MII在诊断内镜阴性烧心上更有优势,给临床治疗提供依据和指导。 展开更多
关键词 胃食管反流 经自然腔道内镜手术 测压法 食管PH监测
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Proteomics analysis reveals a potential new target protein for the lipid-lowering effect of Berberine8998
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作者 Cheng-yin YU Gang-yi LIU +7 位作者 Xiao-hui LIU Yu-zhou GUI Hai-ming LIU Hong-chao ZHENG Darek C GORECKI Asmita V PATEL Chen YU Yi-ping WANG 《中国药理学报:英文版》 SCIE CAS CSCD 2018年第9期1473-1482,共10页
Berberine8998 是有更好类脂化合物阴沉的活动的最新综合的 berberine 衍生物并且改进吸收。这研究的目的是在 vivo 在浆液胆固醇和类脂化合物层次上调查 berberine8998 的效果并且检验包含的机制。在高脂肪的节食(HFD ) 的仓鼠是管理 b... Berberine8998 是有更好类脂化合物阴沉的活动的最新综合的 berberine 衍生物并且改进吸收。这研究的目的是在 vivo 在浆液胆固醇和类脂化合物层次上调查 berberine8998 的效果并且检验包含的机制。在高脂肪的节食(HFD ) 的仓鼠是管理 berberine 或 berberine8998 (50 mgctrical 电导率(> 10 <sup>5</sup><sup>1</sup > m <sup>1</sup>) 被要求。这里,我们表明如此的纯旋转水流来源:有 2.5 摥琠? 桴的传导性的拓扑的绝缘体 BiSb 薄电影?? 展开更多
关键词 类脂化合物 PROTEOMICS 蛋白质 PROTEOMICS 降低胆固醇 新陈代谢 化合物层 生物信息学
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