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Process optimization of an industrial acetic acid dehydration progress via heterogeneous azeotropic distillation
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作者 Xiuhui Huang Zeqiu Li Ying Tian 《中国化学工程学报:英文版》 SCIE EI CAS CSCD 2018年第8期1631-1643,共13页
在实际过载的状况下面的 HAc 脱水进程的模仿的进程模型被用从实际生产收集的进程数据在我们的以前的工作修改标准状况的模型进行。基于实际过程模型,每家工厂的操作优化分析(HAc 脱水列,玻璃瓶和 NPA 再循环列) 用残余曲线地图(RCM )... 在实际过载的状况下面的 HAc 脱水进程的模仿的进程模型被用从实际生产收集的进程数据在我们的以前的工作修改标准状况的模型进行。基于实际过程模型,每家工厂的操作优化分析(HAc 脱水列,玻璃瓶和 NPA 再循环列) 用残余曲线地图(RCM ) 被进行,敏感分析和软件优化模块。基于优化参数,影响在分开的效果和整个进程的精力消费上喂杂质麻省和玻璃瓶的温度被分析。然后,优化策略的整个进程操作与目的被建议全部的 reboiler 责任 Q <sub > C-1 和 C-3 的全部的</sub>在他们上面获得的优化分离参数到达最小的值,保留的 C-1 和 C-3 ,都连接碎再循环并且连接流,并且把 D-1 的温度用作操作变量。优化结果表演全部的 reboiler 责任 Q <sub > 整个过程的全部的 </sub> 能到达 128.32 的最小的价值 ? 敢椠 ? 歌銤~ B 眠? 展开更多
关键词 优化分析 脱水 蒸馏处理 进程模型 异构 醋酸 工业 操作变量
Development and validation of a nomogram for predicting the survival of patients with non-metastatic nasopharyngeal carcinoma after curative treatment 预览 被引量:1
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作者 Wenhua Liang Guanzhu Shen +13 位作者 Yaxiong Zhang Gang Chen Xuan Wu Yang Li Anchuan Li Shiyang Kang Xi Yuan Xue Hou Peiyu Huang Yan Huang Hongyun Zhao Ying Tian Chong Zhao Li Zhang 《癌症:英文版》 SCIE CAS CSCD 2016年第12期658-665,共8页
Background: The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM st... Background: The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage disease vary across a wide spectrum. This study aimed to develop a nomogram that incorporates other clinicopathologic factors for predicting the overall survival(OS) of non-metastatic nasopharyngeal carcinoma(NPC) patients after curative treatments.Methods: We retrospectively collected the clinical data of 1520 NPC patients who were diagnosed histologically between November 2000 and September 2003. The clinical data of a separate cohort of 464 patients who received intensity-modulated radiation therapy(IMRT) between 2001 and 2010 were also retrieved to examine the extensibility of the model. Cox regression analysis was used to identify the prognostic factors for building the nomogram. The predictive accuracy and discriminative ability were measured using the concordance index(c-index).Results: We identiied and incorporated 12 independent clinical factors into the nomogram. The calibration curves showed that the prediction of OS was in good agreement with the actual observation in the internal validation set and IMRT cohort. The c-index of the nomogram was statistically higher than that of the 7th edition TNM staging system for predicting the survival in both the primary cohort(0.69 vs. 0.62) and the IMRT cohort(0.67 vs. 0.63).Conclusion: We developed and validated a novel nomogram that outperformed the TNM staging system in predicting the OS of non-metastatic NPC patients who underwent curative therapy. 展开更多
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A multicenter, retrospectiveepidemiologic survey of the clinical featuresand management of bone metastatic diseasein China 预览
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作者 Yunpeng Yang Yuxiang Ma +7 位作者 Jin Sheng Yan Huang Yuanyuan Zhao Wenfeng Fang Shaodong Hong Ying Tian Cong Xue Li Zhang 《癌症:英文版》 SCIE CAS CSCD 2016年第5期223-228,共6页
Background Bone metastases are common in patients with advanced cancer. Bisphosphonates (BPs) could preventor delay the development of skeleton-related events (SREs). The present study aimed to identify the clinic... Background Bone metastases are common in patients with advanced cancer. Bisphosphonates (BPs) could preventor delay the development of skeleton-related events (SREs). The present study aimed to identify the clinical features ofand treatment strategies for Chinese patients with bone metastases.Methods: Consecutive cancer patients who had bone metastases and received BP treatment were enrolled. A questionnairewas developed to collect the patients' clinical data, as well as information on the diagnosis and managementof bone metastases. Physicians' awareness of the guidelines and knowledge of the application of BP were alsoassessed.Results: A total of 3223 patients with lung cancer (36.5%), breast cancer (30.9%), prostate cancer (8.5%), and gastrointestinalcancer (5.7%) were included in this study. The sites of bone metastases were the thoracic spine (56.0 %),lumbar spine (47.1%), ribs (32.6%), and pelvis (23.2%). The SRE frequency was the highest in patients with multiplemyeloma (36.6%), followed by those with lung cancer (25.9%), breast cancer (20.2%), prostate cancer (18.2%), and gastrointestinalcancer (17.3%). Irradiation to the bone was the most frequent SRE (58% in lung cancer patients, 45% inbreast cancer patients, and 48% in prostate cancer patients). Our survey also showed that 45.5% of patients receivedBP within 3 months after their diagnosis of bone metastases, whereas the remaining 54.5% of patients did not receiveBP treatment until at least 3 months after their diagnosis of bone metastases. The SRE frequency in the former groupwas significantly lower than that in the latter group (4.0% vs. 42.3%, P 〈 0.05). In patients with more than 6 monthsof continuous BP treatment, the mean time to the first SRE was significantly longer than that in patients with lessthan 6 months of continuous BP treatment (7.2 vs. 3.4 months, P 〈 0.05). In addition, 12.2% of the physicians werenot aware of the efficacy of BP in preventing and delayi 展开更多
关键词 Bisphosphonates BONE metastases Skeleton-related events Chinese cancer patients
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Thermal and luminescent properties of 2 μm emission in thulium-sensitized holmium-doped silicate-germanate glass
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作者 Rong Chen Ying Tian +5 位作者 Bingpeng Li Xufeng Jing Junjie Zhang Shiqing Xu Hellmut Eckert Xianghua Zhang 《光子学研究:英文版》 2016年第6期214-221,共8页
In this paper, we present the luminescent properties of Tm3+∕Ho3+co-doped new glass. A series of silicategermanate glass was prepared by the conventional melt-quenching method. In the Tm3+∕Ho3+co-doped silicategerma... In this paper, we present the luminescent properties of Tm3+∕Ho3+co-doped new glass. A series of silicategermanate glass was prepared by the conventional melt-quenching method. In the Tm3+∕Ho3+co-doped silicategermanate glass, a strong emission of 2 μm originating from the Ho3+:5I7→5I8transition can be observed under conventional 808 nm pumping. The characteristic temperatures, structure, and absorption spectra have been measured. The radiative properties of Ho3+in the prepared glass were calculated. The emission cross section of Ho3+ions transition can reach 4.78 × 10-21cm2 around 2 μm, and the FWHM is as high as 153 nm. The energy transfer efficiency between Ho3+and Tm3+has a large value(52%), which indicates the Tm3+∕Ho3+co-doped silicategermanate glass is a suitable candidate for the 2 μm laser. Moreover, the energy transfer mechanism between Tm3+and Ho3+ions was investigated. 展开更多
Long-distance super-exchange and quantum magnetic relaxation in a hybrid metal-organic framework
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作者 田英 申世鹏 +3 位作者 丛君状 闫丽琴 柴一晟 孙阳 《中国物理B:英文版》 SCIE EI CAS CSCD 2016年第1期390-393,共4页
The hybrid metal–organic framework [(CH3)2NH2]Fe(HCOO)3with a perovskite-like structure exhibits a variety of unusual magnetic behaviors at low temperatures. While the long-distance super-exchange through the Fe-O–C... The hybrid metal–organic framework [(CH3)2NH2]Fe(HCOO)3with a perovskite-like structure exhibits a variety of unusual magnetic behaviors at low temperatures. While the long-distance super-exchange through the Fe-O–CH-O–Fe exchange path leads to a canted antiferromagnetic ordering at TN~ 19 K, a second transition of magnetic blocking develops at TB~ 9 K. The stair-shaped magnetization hysteresis loops below TBresemble the behaviors of resonant quantum tunneling of magnetization in single-molecular quantum magnets. Moreover, the magnetic relaxation also exhibits several features of resonant quantum relaxation, such as the exponential law with a single characteristic relaxation time, and the nonmonotonic dependence of relaxation rate on the applied magnetic field with a much faster relaxation around the resonant fields. The origin of quantum tunneling behaviors in the [(CH3)2NH2]Fe(HCOO)3metal–organic framework is discussed in terms of magnetic phase separation due to the modification of hydrogen bonding on the long-distance super-exchange interaction. 展开更多
关键词 量子行为 金属有机 磁弛豫 框架 混合 长距离 量子共振 交换相互作用
A new six-component super soliton hierarchy and its self-consistent sources and conservation laws
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作者 魏含玉 夏铁成 《中国物理B:英文版》 SCIE EI CAS CSCD 2016年第1期394-399,共6页
A new six-component super soliton hierarchy is obtained based on matrix Lie super algebras. Super trace identity is used to furnish the super Hamiltonian structures for the resulting nonlinear super integrable hierarc... A new six-component super soliton hierarchy is obtained based on matrix Lie super algebras. Super trace identity is used to furnish the super Hamiltonian structures for the resulting nonlinear super integrable hierarchy. After that, the selfconsistent sources of the new six-component super soliton hierarchy are presented. Furthermore, we establish the infinitely many conservation laws for the integrable super soliton hierarchy. 展开更多
关键词 孤子族 六分量 自洽 守恒律 哈密顿结构 层次结构 守恒定律 李代数
^18F-FDG PET/CT in differentiating malignant from benign origins of obstructive jaundice 预览
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作者 Shao-Bo Wang Hu-Bing Wu +4 位作者 Quan-Shi Wang Wen-Lan Zhou Ying Tian Yun-Hai Ji Liang Lv 《国际肝胆胰疾病杂志:英文版》 SCIE CAS CSCD 2015年第5期516-522,共7页
BACKGROUND: The various origins of obstructive jaundice make the diagnosis of the disease difficult. This study was undertaken to evaluate the role of 18F-FDG PET/CT in differentiating malignant from benign origins of... BACKGROUND: The various origins of obstructive jaundice make the diagnosis of the disease difficult. This study was undertaken to evaluate the role of 18F-FDG PET/CT in differentiating malignant from benign origins of obstructive jaundice and to quantify the added value of 18F-FDG PET/CT over conventional imaging(enhanced CT and/or MRI).METHODS: Eighty-five patients with obstructive jaundice who underwent 18F-FDG PET/CT within 2 weeks after enhanced CT and/or MRI were reviewed retrospectively. All 18F-FDG PET/CT images were independently evaluated by 2 nuclear medicine physicians who were unaware of other imaging data; differences were resolved by consensus of the physicians. All conventional imaging interpretations, according to the medical records, were reviewed by 2 radiologists to determine the potential value. Final diagnoses were based on histological or surgical findings.RESULTS: Sixty-six patients were diagnosed with malignancies, and 19 patients with benign lesions. The maximum standardized uptake values for malignant and benign lesions causing biliary obstruction were 8.2±4.4 and 4.0±5.0, respectively(P<0.05). The sensitivity, specificity, and overall accuracy for differentiating malignant from benign origins with 18F-FDG PET/CT were 86.4%(57/66), 73.7%(14/19), and 83.5%(71/85), respectively. 18F-FDG PET/CT in conjunction with conventional imaging changed the sensitivity, specificity, and overall accuracy of conventional imaging alone from 75.8%(50/66) to 95.5%(63/66)(P<0.05), 68.4%(13/19) to 57.9%(11/19)(P>0.05), and 74.1%(63/85) to 87.1%(74/85)(P<0.05), respectively.CONCLUSIONS: 18F-FDG PET/CT is of great value in differentiating malignant from benign origins of obstructive jaundice and is a useful adjuvant to conventional imaging. 18F-FDG PET/CT should be recommended for further etiological clarification. 展开更多
关键词 鉴别诊断 恶性肿瘤 黄疸 起源 阻性 CT检查 PET 影像学
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H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway
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作者 Shenglan Gao Wenting Li +5 位作者 Wei Zou Ping Zhang Ying Tian Fan Xiao Hongfeng Gu Xiaoqing Tang 《生物化学与生物物理学报:英文版》 SCIE CAS CSCD 2015年第11期915-924,共10页
关键词 神经保护作用 PC12细胞 皮质酮 抗毒性 硫化氢 通路 脑源性神经营养因子 调制
中国拟天牛亚科一雌性新描述与两新纪录种记述(鞘翅目:拟天牛科)
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作者 田颖 任国栋 李强 《昆虫分类学报》 CSCD 2015年第2期123-128,共6页
报道中国拟天牛亚科西藏1雌性新发现:Diplectrus bistigmaeus Zhang, Ren et Ba, 2012,并对其进行描述。Nacerdes(Xanthochroa)brendelli Svihla,1987和N.(Asiochroa)mimoncomeroides Svihla,1998两种首次在中国记录,并基于DIVA... 报道中国拟天牛亚科西藏1雌性新发现:Diplectrus bistigmaeus Zhang, Ren et Ba, 2012,并对其进行描述。Nacerdes(Xanthochroa)brendelli Svihla,1987和N.(Asiochroa)mimoncomeroides Svihla,1998两种首次在中国记录,并基于DIVA-GIS对它们在中国的潜在分布区进行了预测。 展开更多
关键词 拟天牛 新纪录 地理分布
不同浓度玻璃酸钠对新西兰兔干眼眼表变化的影响 预览 被引量:3
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作者 王双勇 田英 +2 位作者 程燕 朱海峰 吴洁 《国际眼科杂志》 CAS 2015年第10期1705-1708,共4页
目的:对比观察不同浓度的玻璃酸钠对干眼眼表变化的影响。 方法:制备新西兰兔干眼动物模型,使用1g/L玻璃酸钠和3g/L玻璃酸钠滴滴液治疗,分别作为低浓度治疗组(B组)和高浓度治疗组(C组),生理盐水治疗作为对照组(A组)。分别观察... 目的:对比观察不同浓度的玻璃酸钠对干眼眼表变化的影响。 方法:制备新西兰兔干眼动物模型,使用1g/L玻璃酸钠和3g/L玻璃酸钠滴滴液治疗,分别作为低浓度治疗组(B组)和高浓度治疗组(C组),生理盐水治疗作为对照组(A组)。分别观察角膜荧光染色、泪液分泌试验、结膜杯状细胞及黏蛋白表达和组织学变化。 结果:治疗后D7和D14时,B组及C组角膜荧光染色评分低于A组(P〈0.05),泪液分泌、杯状细胞密度及黏蛋白含量高于A组(P〈0.05)。 C组角膜泪液分泌和杯状细胞密度高于B组(P〈0.05)。与B组和C组相比较,A组角膜及结膜上皮细胞层变薄,角膜及结膜基质未见明显异常。 结论:玻璃酸钠能够改善干眼眼表损害,且高浓度治疗效果优于低浓度。 展开更多
关键词 玻璃酸钠 干眼 眼表损害
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Spectroscopic properties of thulium ions in bismuth silicate glass
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作者 王欣 胡丽丽 +2 位作者 李科峰 田颖 凡思军 《中国光学快报:英文版》 SCIE EI CAS CSCD 2012年第10期44-48,共5页
A new type of bismuth silicate glass (Bi2O3-SiO2-ZnO-Al2O3-La2O3) doped with Tm2O3 is prepared by melt-quenching method. The thermal stability of the glass is examined by differential scanning calorimetry. No crystall... A new type of bismuth silicate glass (Bi2O3-SiO2-ZnO-Al2O3-La2O3) doped with Tm2O3 is prepared by melt-quenching method. The thermal stability of the glass is examined by differential scanning calorimetry. No crystallization peak is found. Using the absorption and emission spectra, the absorption and emission cross-sections are calculated. Their maximum data are 2.9×10-21cm2 at 1663 nm and 4.7×10-21cm2 at 1826 nm, respectively. Using the Judd-Ofelt theory, the radiation transition probabilities and radiative lifetimes are obtained. The extended overlap integral method is applied to analyze energy transfer process among the Tm3+ ions. The transfer constants of cross-relaxation and energy migration among the Tm3+ ions at the 3H4 level are 7.60×10-40 and 14.98×10-40 cm6 /s, respectively. The critical transfer radius for cross-relaxation is 0.99 nm. The cross relaxation process is easy to realize and is favorable for obtaining ~2-μm laser. 展开更多
关键词 硅酸盐玻璃 稀土离子 氧化铋 光谱特性 JUDD-OFELT理论 差示扫描量热法 辐射跃迁几率 吸收光谱
Efficient 2.7-μm emission in Er3+-doped bismuth germanate glass pumped by 980-nm laser diode
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作者 赵国营’ 田颖 +2 位作者 范慧艳 张军杰 胡丽丽 《中国光学快报:英文版》 SCIE EI CAS CSCD 2012年第9期64-66,共3页
An Er 3+-doped lead-free bismuth germanate glass is synthesized. Its 2.7-μm emission property is analyzed, and the efficient 2.7-μm emission from the glass is observed under 980-nm laser diode excitation. The prepar... An Er 3+-doped lead-free bismuth germanate glass is synthesized. Its 2.7-μm emission property is analyzed, and the efficient 2.7-μm emission from the glass is observed under 980-nm laser diode excitation. The prepared glass possesses high spontaneous transition probability (64.8 s 1 ) and a large calculated emission cross section (6.61×10 21 cm 2 ) corresponding to the 4I11/2→4I13/2 transition. The multiphonon relaxation rate for the excited state 4I11/2 is only 236 s 1 . Therefore, the excellent spectroscopic properties and outstanding thermal stability suggest that this glass is a suitable host for developing solid-state lasers operating in the mid-infrared. 展开更多
关键词 激光二极管泵浦 发射特性 锗酸铋 铒掺杂 玻璃 纳米 跃迁几率 工作状态
EGFR inhibitors sensitize non-small cell lung cancer cells to TRAIL-induced apoptosis 预览
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作者 Fei Xu Ying Tian +4 位作者 Yan Huang Ling-Ling Zhang Zheng-Zheng Guo Jia-Jia Huang Tong-Yu Lin 《癌症:英文版》 SCIE CAS CSCD 北大核心 2011年第10期 701-711,共11页
Apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) can be regulated by the epidermal growth factor(EGF) signaling pathway.In this study,recombinant adenoviral vectors that encode TRAIL... Apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) can be regulated by the epidermal growth factor(EGF) signaling pathway.In this study,recombinant adenoviral vectors that encode TRAIL gene from the hTERT/RGD promoter(AdTRAIL) was combined with drugs including gefitinib,elotinib,and cetuximab that inhibit EGFR and the EGF signaling pathway in non-small cell lung cancer(NSCLC) cell lines to investigate their antitumor activity.In vitro,compared to single reagent,AdTRAIL combined with EGFR inhibitors reduced proliferation and enhanced apoptosis in H460,A549,and SW1573 cell lines.Western blot results suggested that these effects were relative to up-regulation of pro-apoptosis protein BAX and down-regulation of p-AKT.In vivo,AdTRAIL combined with cetuximab resulted in a significant growth reduction in H460 xenografts without damage to the main organs of nude mice.Histological examination and TUNEL analyses of xenografts showed that cetuximab enhanced cell apoptosis induced by AdTRAIL.These results indicate that EGFR inhibitors enhanced AdTRAIL anti-tumor activity in NSCLC cell lines and that inhibiting the AKT pathway played an important role in this enhancement. 展开更多
关键词 肿瘤坏死因子相关凋亡诱导配体 细胞凋亡 TRAIL EGFR 抑制剂 肺癌细胞 表皮生长因子受体 非小细胞肺癌
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Cyclosporine, prednisone, and high-dose immunoglobulin treatment of angioimmunoblastic T-cell lymphoma refractory to prior CHOP or CHOP-like regimen 预览
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作者 Xing-Gui Chen He Huang +6 位作者 Ying Tian Cheng-Cheng Guo Chao-Yong Liang Yao-Ling Gong Ben-Yan Zou Rui-Qing Cai Tong-Yu Lin 《癌症:英文版》 SCIE CAS CSCD 北大核心 2011年第10期 731-738,共8页
Angioimmunoblastic T-cell lymphoma(AITL) is a rare,distinct subtype of peripheral T-cell lymphoma,possessing an aggressive course and poor prognosis with no standard therapy.Twelve patients who have failed at least tw... Angioimmunoblastic T-cell lymphoma(AITL) is a rare,distinct subtype of peripheral T-cell lymphoma,possessing an aggressive course and poor prognosis with no standard therapy.Twelve patients who have failed at least two initial CHOP or CHOP-like regimens were enrolled in this study and treated with individualized cyclosporine(CsA),prednisone(PDN),and monthly,high-dose intravenous immunoglobulin(HDIVIG).The dose of CsA was adjusted individually based on the blood trough concentration of CsA and renal function.All patients were examined for response,toxicity and survival.The most significant toxicities(≥ grade 2) were infection(16.7%),renal insufficiency(8.3%),hypertension(8.3%),diabetes(8.3%) and insomnia(16.7%).Discontinuation of treatment occurred in one patient(8.3%) due to grade 3 renal toxicity and subsequent grade 4 pulmonary infection.Treatment-related death was not observed.The overall response rate was 75.0%(complete response,33.3%;partial response,41.7%).With a median follow-up of 25.5 months,the median duration of response was 20 months(range,12 to 49 months) and the median progression-free survival(PFS) was 25.5 months(range,10 to 56 months).The 2-year PFS rate was 81.5%.Our findings indicate the combination of CsA,PDN and HDIVIG is an effective salvage regimen for refractory or relapsed AITL with predictable and manageable toxicity. 展开更多
关键词 免疫球蛋白 高剂量 淋巴瘤 T细胞 环孢素 强的松 母细胞 治疗
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Definition of the South China Sea summer monsoon onset
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作者 田莹 王启 《中国海洋湖沼学报:英文版》 SCIE CAS CSCD 2010年第6期1281-1289,共9页
我们分析发作是建立由指示物的一个多数是更可认识的一个 SCSSM 发作时间系列的华南海夏天季风(SCSSM ) 的统计上不同的定义。与承认索引,我们决定一个关键区域( 105 掳E 鈥? 12.5 掳E , 7.5 掳N 鈥? 2.5 掳N )并且在这个关键区... 我们分析发作是建立由指示物的一个多数是更可认识的一个 SCSSM 发作时间系列的华南海夏天季风(SCSSM ) 的统计上不同的定义。与承认索引,我们决定一个关键区域( 105 掳E 鈥? 12.5 掳E , 7.5 掳N 鈥? 2.5 掳N )并且在这个关键区域把带的风部件定义为一个新 SCSSM 发作索引,用大气的研究的环境预言/公民中心的国家中心的每日的吝啬的分析数据。在用这个索引决定的 SCSSM 的发作前后的大气的发行量在这定义纸 preliminarily 被学习。结果证明索马里 跨equatorial 流动被提高,在热带印度洋的最大的西的风向北方变,在孟加拉和南部的半球的海湾的气旋夫妇变弱并且移动东方,在华南海上的传送对流增加,并且副热带的高度在 SCSSM 的爆发以后从华南海撤退。由分析大气的发行量,在 1984 和 1999, SCSSM 爆发在五,这被发现 29 和 23,分别地它与发作时间用我们的索引决定了一致。 展开更多
关键词 南海夏季风爆发 中国南海 定义 副热带高压 大气环流 越赤道气流 时间序列 夏季季风
90例粘膜相关淋巴瘤患者的临床预后分析 预览 被引量:6
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作者 翟林柱 肖健 +6 位作者 付晓红 叶昇 郭琤琤 黄嘉佳 田莹 林汉良 林桐榆 《癌症:英文版》 SCIE CAS CSCD 北大核心 2009年第7期734-739,共6页
背景与目的:粘膜相关淋巴瘤是一种边缘带非霍奇金淋巴瘤,由于其惰性的临床过程,对其临床特点及预后因素的报道比较少见。本研究对该肿瘤的临床特点及预后因素进行探讨。方法:收集1997年12月至2007年2月经病理确诊的粘膜相关淋巴瘤... 背景与目的:粘膜相关淋巴瘤是一种边缘带非霍奇金淋巴瘤,由于其惰性的临床过程,对其临床特点及预后因素的报道比较少见。本研究对该肿瘤的临床特点及预后因素进行探讨。方法:收集1997年12月至2007年2月经病理确诊的粘膜相关淋巴瘤病例共90例,分为胃组和胃外组进行回顾性分析。结果:全组90例患者中,中位年龄52岁(13~77岁),原发于胃的23例(25.6%),胃外67例(74.4%)临床分期为Ⅰ~Ⅱ期的75例(83.3%),Ⅲ~Ⅳ期15例(16.7%)多器官累及的患者占34.4%,淋巴结累及的患者占44.4%,原发胃外的患者更易出现淋巴结转移(P=0.040)。经治疗后完全缓解率为72.1%。中位随访时间31.4个月,淋巴结阳性和阴性患者的5年生存率分别为58.7%和88.4%(P=0.012)。IPI评分0~2分和首次治疗后完全缓解的患者中位无进展时间分别为61.9个月和未达到,而IPI评分〉2分和首次治疗未达完全缓解的患者中位无进展时间分别为5.2个月和15.0个月,结果差异具有统计学意义(P=0.005和P=0.030)。在67例胃外组患者中,IPI评分是总生存的独立预后指标(P=0.023)。结论:粘膜相关淋巴瘤应被认为是一种广泛播散的惰性淋巴瘤,原发胃外的患者更易出现淋巴结侵犯。具有不良预后因素包括淋巴结侵犯,IPI评分〉2和首次治疗疗效未达到完全缓解的患者应给予更加积极的治疗. 展开更多
关键词 非霍奇金淋巴瘤 粘膜相关淋巴瘤 临床特征 预后
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近视人群原发性开角型青光眼相关因素研究 预览 被引量:1
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作者 杨问学 田莹 +1 位作者 朱秀萍 高伟 《国际眼科杂志》 CAS 2008年第2期 398-399,共2页
目的:分析眼轴长度、中央角膜厚度与眼压的关系,探讨它们对原发性开角型青光眼(POAG)的诊断意义。方法:对118例210眼早期原发性开角型青光眼患者以及58例116眼对照组(根据屈光度的不同分为正视组,低中度近视组和高度近视组3组)... 目的:分析眼轴长度、中央角膜厚度与眼压的关系,探讨它们对原发性开角型青光眼(POAG)的诊断意义。方法:对118例210眼早期原发性开角型青光眼患者以及58例116眼对照组(根据屈光度的不同分为正视组,低中度近视组和高度近视组3组)进行中央角膜厚度,眼轴长度,眼压测量,并用统计学的方法对其结果进行比较。结果:正常组中央角膜厚度,眼轴长度与眼压呈正相关关系(r1=0.351,r2=0.883)。两组人群比较,中央角膜厚度、眼轴长度均有极显著性差异(P〈0.01);而在同一组内不同屈光度比较,中央角膜厚度随着屈光度的增加而降低;眼轴长度随着屈光度的增加而增加。结论:了解近视人群的特点,有利于提高临床医师对近视合并POAG的早期诊断水平。 展开更多
关键词 近视 原发性开角型青光眼 角膜厚度 轴长
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探地雷达数据实时成像和预处理系统设计 预览 被引量:2
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作者 李盈 田茂 《微计算机信息》 北大核心 2006年第01S期 205-207,共3页
探地雷达作为目前分辨率、效率最高的地下目标探测设备之一在城建、变通、地质、考古、国防等部门得到越来越广泛的应用。将雷达主机采集到的大量数据高速地传输到PC机上实时地显示,并对数据进行预处理以消除部分干扰.得到更准确、清... 探地雷达作为目前分辨率、效率最高的地下目标探测设备之一在城建、变通、地质、考古、国防等部门得到越来越广泛的应用。将雷达主机采集到的大量数据高速地传输到PC机上实时地显示,并对数据进行预处理以消除部分干扰.得到更准确、清晰的地质图像,对雷迭系统而言是非常必要的。论文即介绍了作者自行设计和实现的探地雷达高速传输数据的实时显示并使用克希霍夫偏移算法进行数据预处理的软件系统,给出了该系统的工作原理和实现方法。 展开更多
关键词 探地霄达 SB2.0 实时显示 克希霍夫偏移
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正常青少年黄斑区活体测量及分析 预览
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作者 赵俊宏 吕沛霖 +6 位作者 赵燕麟 朱秀萍 李英泰 田莹 张学辉 杨文学 徐敏 《国际眼科杂志》 CAS 2004年第3期 463-466,共4页
目的:应用视网膜厚度分析仪(RTA)对青少年正常眼黄斑区视网膜厚度进行测定,以确定国人参考值范围及正常地形图的特点.方法:对100眼经眼科检查确认的正常眼按同一方法进行黄斑区RTA图像采集,使用随机软件对其厚度进行测量,并按照青少年... 目的:应用视网膜厚度分析仪(RTA)对青少年正常眼黄斑区视网膜厚度进行测定,以确定国人参考值范围及正常地形图的特点.方法:对100眼经眼科检查确认的正常眼按同一方法进行黄斑区RTA图像采集,使用随机软件对其厚度进行测量,并按照青少年黄斑地形图特点,人工测量不同黄斑分区距中心小凹的跨度,计算黄斑不同分区的范围及视网膜厚度的平均值.对结果应用多元回归方法探讨年龄、性别、眼别对视网膜厚度的影响.结果:黄斑区可分为中心小凹区、中心凹区、旁中心凹区,中心小凹直径为428±165 μ m,中心凹平均直径为1356±277 μ m,旁中心区平均直径为1450±226 μ m;黄斑部视网膜平均厚度168±14.3μm,黄斑各部位测量所得数值为:中心小凹区为128±22μm,中心凹区为138±17.6μ m,旁中心凹区为169±15μm,不同分区视网膜厚度有明显差异(P<0.05),年龄对中心凹区和中心小凹区平均厚度影响最大(P<0.05);不同性别、眼别对视网膜厚度无影响(P>0.05).我国青少年不同分区视网膜平均厚度低于RTA软件的正常参考值,差异有显著性(P<0.01).结论:RTA能够对活体视网膜厚度进行精确的量化测定,青少年黄斑区厚度测定值可作为我国正常青少年人群黄斑视网膜厚度的正常值参考. 展开更多
关键词 青少年 黄斑区 活体测量 分析
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心力衰竭大鼠增龄过程中β3-肾上腺素能受体和内皮源性一氧化氮合酶表达变化的研究 预览 被引量:3
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作者 孔一慧 李为民 田颖 《中国临床康复》 CAS CSCD 2004年第33期 7407-7409,共3页
目的:研究异丙肾上腺素诱导的心力衰竭大鼠随增龄β3肾上腺素能受体(β3受体)及其信号转导途径中相关基因内皮源性一氧化氮合酶(endomyocardial nitric oxide synthase,eNOS)的表达,探讨β3受体和eNOS在老年大鼠心力衰竭中的作用.方法:... 目的:研究异丙肾上腺素诱导的心力衰竭大鼠随增龄β3肾上腺素能受体(β3受体)及其信号转导途径中相关基因内皮源性一氧化氮合酶(endomyocardial nitric oxide synthase,eNOS)的表达,探讨β3受体和eNOS在老年大鼠心力衰竭中的作用.方法:将异丙肾上腺素诱导的心力衰竭大鼠存活者随机分为成年组(4月龄)、成年对照组、老年组(20月龄)、老年对照组(各7只).①血流动力学测定.②免疫组化测β3受体蛋白和eNOS基因蛋白表达.③反转录多聚酶链反应(RT-PCR)方法测β3受体mRNA和eNOS mRNA表达.结果:①随增龄成年组和老年组比较,老年组左室收缩末压(LV end systolic pressure,PES),左室压力最大上升速率(maximal rates of rise of ventricular pressure,dp/dtmax),左室压力最大下降速度(maximal rates of decline of ventricular pressure,dp/dtmin)绝对值较成年组明显降低[PES:(72.3±5.7)和(93.7±9.6)mm Hg;dp/dtmax:(7 119±386)和(8 352±339)mm Hg/s;dp/dtmin:(-5 011±380)和(-6143±534)mmHg/s,F=22.767,18.647,7.930,P均<0.05],左室等容舒张时间常数(constant of LV relaxation,Tc)、左室舒张末压(LV end diastolic pressure,PED)明显增加[Tc:(22.21±2.53)和(16.44±1.49)ms,F=6.370,P<0.01;PED:(12.51±1.15)和(9.01±0.42)mm Hg,F=20.157,P<0.05],且两组与相应对照组比较血流动力学恶化均较明显.②免疫组化测定心衰大鼠β3受体和eNOS蛋白表达量,eNOS和β3受体在心衰大鼠心肌组织内表达量成年组较老年组阳性细胞明显增加,且两组与相应对照组比较增加显著(F=6.861,5.198,P<0.05~0.01).③RT-PCR法测定eNOS mRNA与β-actin的比值老年组(1.22±0.10)较成年组(0.37±0.04)和老年对照组(0.93 ±0.12)增加显著;成年组较成年对照组(0.23±0.07)增加明显(F=4.792,P<0.05).心衰大鼠β3受体mRNA与β-actin的比值亦随增龄明显增加(F=8.276,P=0.001).结论:心衰大鼠随年龄的增加β3受体水平和eNOS表达明显增加,β3受体和eNOS表达过度增高可导致心功 展开更多
关键词 心力衰竭 充血性 受体 肾上腺素能Β 一氧化氮合酶 基因表达 衰老
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