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Gastric cancer-derived heat shock protein-gp96 peptide complex enhances dendritic cell activation 预览
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作者 Wen-Wen Lu Hong Zhang +1 位作者 You-Ming Li Feng Ji 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第24期4390-4398,共9页
AIM To investigate the role of heat shock protein(HSP)-glycoprotein(gp)96 in dendritic cells(DCs)and lymphocytes induction in gastric cancer(GC). METHODS Human GC cell lines KATOIII,MKN-28 and SGC-7901were infected wi... AIM To investigate the role of heat shock protein(HSP)-glycoprotein(gp)96 in dendritic cells(DCs)and lymphocytes induction in gastric cancer(GC). METHODS Human GC cell lines KATOIII,MKN-28 and SGC-7901were infected with adenovirus gp96 at a multiplicity of infection of 100.gp96-GC antigen peptide complexes were purified.MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)assay,lactate dehydrogenase(LDH)release assay and enzymelinked immunosorbent assay were used to determine allo-reactive T cell stimulation,natural killer(NK)cell activity and expression of cytokines(such as interleukin(IL)-10,IL-12,interferon(IFN)-γand tumor necrosis factor(TNF)-α),respectively.Effect of cytotoxic T lymphocyte(CTL)on DCs incubated with HSP-gp96was also evaluated by LDH release.All assays were performed in triplicate and the average values were reported.Comparison between groups was conducted using Student’s t test.RESULTS T cells incubated with HSP-gp96 exhibited a marked increase in proliferation in a dose-dependent manner(P<0.05).NK cell activity after gp96-GC peptide complex treatment was significantly higher than that after antigen peptide treatment(P<0.05).The activity of CTLs incubated with DCs from three GC cells lines was obviously higher than that stimulated by GC antigen at ratios of 50:1,25:1,10:1,and 5:1(P<0.05).Furthermore,the secretion of TNF-α,IL-10,IL-12(P70)and IFN-γmarkedly increased after incubation with HSP-gp96(P<0.05).CONCLUSION HSP-gp96 promotes T cell response,enhances DC antigen presentation and induces cytokine secretion,as well.HSP-gp96 has potential as immunotherapy for elimination of residual GC cells. 展开更多
关键词 胃的癌症 加热吃惊蛋白质 gp96 T 淋巴细胞 树枝状的房间 自然漂亮房间 细胞毒素的 T 淋巴细胞 免疫治疗
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Gastric xanthelasma and metabolic disorders: A large retrospective study among Chinese population 预览
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作者 Yi Chen Xin-Jue He +1 位作者 Min-Jian Zhou You-Ming Li 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第43期7756-7764,共9页
AIM To gain knowledge of xanthelasma,a large populationbased study was conducted. METHODS Patients who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital,College of Medicine,Zhejiang Universit... AIM To gain knowledge of xanthelasma,a large populationbased study was conducted. METHODS Patients who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China during Jan 2009 to Nov 2016 were included. General characteristics as well as clinical data were collected,including blood routine,serum biochemical analysis,endoscopic findinds,histological evaluation and comorbiditie. Statistical analyses was performed using SPSS 20.0 software for Windows(IBM Inc.,Chicago,IL,United States) using Student’s t-test,Mann-Whitney U test,χ2 test,univariable and multivariable logistic analysis. 2-tailed P value less than 0.05 was considered to be statistically significant. RESULTS A total of 176006 endoscopies were retrieved and we included 1370 xanthelasma participants(703 men,667 women) in this study. Prevalence of xanthelasma was 0.78% with average age of 56.6 ± 11.2 years. Chief complaint of xanthelasma consisted abdominal pain (24.2%),up-abdominal discomfort(14.1%),abdominal distention(10.1%),dyspepsia(9.1%),et al. Most xanthelasma occurred as single lesion in gastric antrum. Xanthelasma patients witnessed higher Helicobacter pylori(H. pylori) infection rate,more of other gastric lesions including atrophy,intestinal metaplasia and dysplasia(P < 0.01). In xanthelasma patients,serum carcinoembryonic antigen,triglyceride,fasting glucose,neutrophil,neutrophil-to-lymphocyte ratio were significantly higher,and high density lipoprotein-cholesterol,lymphocyte was lower(P < 0.05). Xanthelasma accompanied with more fatty liver disease and hepatic cyst,but fewer gallbladder polyp(P < 0.05). In logistic regression,it revealed that fasting plasma glucose(OR = 3.347,1.170-9.575,P < 0.05),neutrophil(OR = 1.617,1.003-2.605,P < 0.05),and carcinoembryonic antigen(OR = 2.011,1.236-3.271,P < 0.01) were all independent risk factors in xanthelasma. CONCLUSION Current study described a large xanthelasma cohort in Chinese population,revealed its relationship with H. pyl 展开更多
关键词 胃的 xanthelasma Helicobacter pylori 感染 胃的发育异常 新陈代谢的混乱
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Clinical guidelines of non-alcoholic fatty liver disease: A systematic review 预览
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作者 Jin-Zhou Zhu Kelseanna Hollis-Hansen +5 位作者 Xing-Yong Wan Su-Juan Fei Xun-Lei Pang Fan-Dong Meng Chao-Hui Yu You-Ming Li 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第36期8226-8233,共8页
AIM To perform a systematic review to grade guidelines and present recommendations for clinical management of non-alcoholic fatty liver disease(NAFLD).METHODS A database search was conducted on Pub Med for guidelines ... AIM To perform a systematic review to grade guidelines and present recommendations for clinical management of non-alcoholic fatty liver disease(NAFLD).METHODS A database search was conducted on Pub Med for guidelines published before May 2016, supplemented by reviewing relevant websites. The Appraisal of Guidelines for Research and Evaluation(ARGEE) instrument Ⅱ was a tool designed to appraise the methodological rigor and transparency in which a clinical guideline is developed and it is used internationally. it was used to appraise the quality of guidelines in this study. The inclusion criteria include: clinical NAFLD guidelines for adults, published in English, and released by governmental agencies or key organizations.RESULTS Eleven guidelines were included in this study. Since 2007, guidelines have been released in Asia(3 in China, 1 in South Korea, and 1 in Japan), Europe(1 in italy),America(1 in United States and 1 in Chile) and three international agencies [European associations joint, Asia-Pacific Working Party and World Gastroenterology Organization(WGO)]. Using the ARGEE Ⅱ instrument, we found US 2012 and Europe 2016 had the highest scores, especially in the areas of rigor of development and applicability. Additionally, italy 2010 and Korea 2013 also presented comprehensive content, rigorous procedures and good applicability. And WGO 2014 offered various algorithms for clinical practice. Lastly, a practical algorithm for the clinical management was developed, based on the recommended guidelines.CONCLUSION This is the first systematic review of NAFLD guidelines. it may yield insights for physicians and policy-makers in the development and application of guidelines. 展开更多
关键词 DIAGNOSIS Management Non-alcoholic FATTY LIVER DISEASE Systematic REVIEW Treatment
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Prevalence of fatty liver disease and the economy in China: A systematic review 预览
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作者 Jin-Zhou Zhu Qin-Yi Zhou +4 位作者 Yu-Ming Wang Yi-Ning Dai Jiang Zhu Chao-Hui Yu You-Ming Li 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2015年第18期5695-5706,共12页
AIM: To investigate the relationship between the economy and the adult prevalence of fatty liver disease(FLD) in mainland China. METHODS: Literature searches on the Pub Med and Chinese National Knowledge Infrastructur... AIM: To investigate the relationship between the economy and the adult prevalence of fatty liver disease(FLD) in mainland China. METHODS: Literature searches on the Pub Med and Chinese National Knowledge Infrastructure databases were performed to identify eligible studies published before July 2014. Records were limited to crosssectional surveys or baseline surveys of longitudinal studies that reported the adult prevalence of FLD and recruited subjects from the general population or community. T... 展开更多
关键词 FATTY liver disease EPIDEMIOLOGY GROSS domestic product PER capita PREVALENCE Economy
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Seven-day triple therapy is a better choice for Helicobacter pylori eradication in regions with low antibiotic resistance 预览
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作者 Yue-FengTong JunLv +8 位作者 Li-YuanYing FangXu BoQin Ming-TongChen FeiMeng Miao-YingTu Ning-MinYang You-MingLi Jian-ZhongZhang 《世界胃肠病学杂志:英文版》 SCIE CAS 2015年第46期13073-13079,共7页
AIM: To investigate whether 7-d triple therapies are still valid in populations with low levels of resistance.METHODS: A total of 1106 Helicobacter pylori(H. pylori)-positive patients were divided into three groups,ea... AIM: To investigate whether 7-d triple therapies are still valid in populations with low levels of resistance.METHODS: A total of 1106 Helicobacter pylori(H. pylori)-positive patients were divided into three groups,each of which received one type of 7-d triple therapy. Therapeutic outcomes of the patients were assessed by the 13C-urea breath test at 8 wk after treatment. The susceptibility of H. pylori to antibiotics was determined by an agar-dilution method. Data analysis was performed by χ2 tests.RESULTS: The eradication rates in groups A,B and C were 90.71%(332/366),90.46%(313/346) and 90.87%(189/208),respectively(P = 0.986). The resistance rates were 8.91% for clarithromycin,14.78% for levofloxacin and 0% for amoxicillin. The eradication rate was significantly different between clarithromycin-and levofloxacin-resistant patients(P < 0.05) in group A. Patients whose treatment failed in group A also had a higher clarithromycin resistance rate than did successive patients(P = 0.034). However,levofloxacin resistance had no obvious influence on the eradication rate. Furthermore,three main antibiotics(clarithromycin,levofloxacin and amoxicillin) had lower DID(defined daily dose per 1000 inhabitants per day) in this city.CONCLUSION: Clarithromycin resistance is the main reason for the failure of 7-d triple therapy. In populations with low levels of resistance,a 7-d triple therapy is a viable choice. The choice of therapy should not be influenced by conditions in high antibiotic resistance regions. 展开更多
关键词 HELICOBACTER PYLORI Seven-day TRIPLE therapy Eradi
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Screening for pancreatic cancer in familial high-riskindividuals: A systematic review 预览 被引量:1
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作者 Lu, Chao Xu, Cheng-Fu +3 位作者 Wan, Xing-Yong Zhu, Hua-Tuo Yu, Chao-Hui Li, You-Ming 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2015年第28期8678-8686,共9页
AIM To analyze the benefits and harms of pancreaticcancer screening in familial high-risk individuals (HRIs).METHODS: Studies were identified by searchingPubMed, EBSCO, ClinicalTrials.gov and the Cochranedatabase f... AIM To analyze the benefits and harms of pancreaticcancer screening in familial high-risk individuals (HRIs).METHODS: Studies were identified by searchingPubMed, EBSCO, ClinicalTrials.gov and the Cochranedatabase from database inception to June 2014.We also obtained papers from the reference lists ofpertinent studies and systematic reviews. Englishlanguagetrials and observational studies were searched.The key words used as search terms were "screening"and "surveillance". Cost-effectiveness, diagnostic rate,survival rate, mortality and adverse events were theoutcomes of interest. Age, sex, lifestyle and otherconfounding factors were also considered. However,anticipating only a few of these studies, we also includedobservational studies with or without control groups. Wealso included studies concerning the anxiety associatedwith pancreatic cancer risk and other psychologicalchanges in familial HRIs. We extracted details on studydesign, objectives, population characteristics, inclusioncriteria, year of enrollment, method of screening,adjusted and unadjusted mortality, cost-effectivenessand adverse events from the included studies. Studieswere assessed using the Reporting of Observationalstudies in Epidemiology (STROBE) checklist.RESULTS: Sixteen studies on pancreatic cancerscreening were included. Five studies included controlgroups, nine were observational studies without controlgroups, and the other two studies investigated theworry associated with pancreatic cancer risk. We foundthat pancreatic cancer screening resulted in a highcurative resection rate (60% vs 25%, P = 0.011), longermedian survival time (14.5 mo vs 4 mo, P 〈 0.001),and higher 3-year survival rate (20% vs 15.0%, P =0.624). We also found that familial HRIs had a higherdiagnostic rate of pancreatic tumors than controls (34% vs 7.2%, P 〈 0.001). In patients who underwent regularphysical examinations, more stage Ⅰ pancreatic cancerswere observed (19% vs 2.6%, P = 0.001). In addition,endoscopic ultrasonogra 展开更多
关键词 PANCREATIC cancer SCREENING BENEFIT Familialhigh-risk individuals PANCREATIC tumor
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Is Helicobacter pylori infection associated with glycemiccontrol in diabetics? 预览
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作者 Dai, Yi-Ning Yu, Wei-Lai +3 位作者 Zhu, Hua-Tuo Ding, Jie-Xia Yu, Chao-Hui Li, You-Ming 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2015年第17期5407-5416,共10页
AIM To investigate whether Helicobacter pylori (H.pylori ) infection is associated with glycemic controland whether hyperglycemia is modified by eradicationtherapy.METHODS: The databases of PubMed, CochraneLibrary,... AIM To investigate whether Helicobacter pylori (H.pylori ) infection is associated with glycemic controland whether hyperglycemia is modified by eradicationtherapy.METHODS: The databases of PubMed, CochraneLibrary, Chinese BioMedicine Web Base and ChineseScience and Technology Journals were searchedfrom inception to June 2014. Studies examining theassociation between H. pylori infection and glycemiccontrol and?or the effect of eradication treatment onglycemic control in diabetic humans were eligible forinclusion. Meta-analyses were conducted using theReview Manager software version 5.2. The outcomemeasures are presented as weighed mean differences(WMDs) with 95% confidence intervals (CIs). Statisticalheterogeneity was assessed by the Cochran Q test andthe I 2 statistic.RESULTS: A total of 21 relevant publications wereidentified. A meta-analysis of 11 studies with 513patients with diabetes mellitus (DM) showed significantlylower glycosylated hemoglobin (HbA1c) levels in the H.pylori -negative than H. pylori -positive DM participants(WMD = 0.43, 95%CI: 0.07-0.79; P = 0.02). In childrenand adolescents with type 1 DM (T1DM), there wasa positive association between H. pylori infection andHbA1c level (WMD = 0.35, 95%CI: 0.05-0.64; P = 0.02),but there was no difference in those with type 2 DM(T2DM, WMD = 0.51, 95%CI: -0.63-1.65; P = 0.38). Ameta-analysis of six studies with 325 T2DM participantsshowed a significant difference in the fasting plasmaglucose levels between H. pylori -positive and H. pylori -negative participants (WMD = 1.20, 95%CI: 0.17-2.23;P = 0.02). Eradication of H. pylori did not improveglycemic control in the T2DM participants in a threemonthfollow-up period (HbA1c decrease: WMD =-0.03, 95%CI = -0.14-0.08; P = 0.57; fasting plasmaglucose decrease: WMD = -0.06, 95%CI: -0.36-0.23;P = 0.68). Glycemic control was significantly betterin T1DM participants who were not reinfected thanin those who were reinfected (HbA1c: WMD = 0.72,95%CI: 0 展开更多
关键词 Diabetes MELLITUS ERADICATION Glycemiccontrol HELICOBACTER PYLORI Meta-analysis REINFECTION
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Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences 预览
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作者 Ya-NanGong You-MingLi +27 位作者 Ning-MinYang Hong-ZhangLi FengGuo LangLin Qun-YingWang Jia-KunZhang Zi-ZhongJi Ji-BoMao Jun-LiangMao Zheng-ChaoShi Wu-HengTang Xin-JianZhu WeiShao Xiao-FengZhang Xing-HuaWang Yue-FengTong Mi-ZuJiang Guang-LanChen Zhi-YongWang Hui-MinTu Guo-FaJiang Jian-ShengWu Xu-PengChen Qiu-LongDing HongOuyang Feng-ZheJin Yan-LiXu Jian-ZhongZhang 《世界胃肠病学杂志:英文版》 SCIE CAS 2015年第3期944-952,共9页
AIM:To evaluate the efficacy of centralized culture and possible influencing factors.METHODS:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(H.pylori) infection from 26 hospitals in Zh... AIM:To evaluate the efficacy of centralized culture and possible influencing factors.METHODS:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(H.pylori) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal endoscopy.Gastric mucosal biopsies were taken from the antrum for culture.These biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 h.The culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 test.An additional 5736 biopsies from H.pylori-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory setting.RESULTS:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the H.pylori-positive quality control specimens.In the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport group.In contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P < 0.001).During transportation,the average natural temperature increased from 4.67 to 29.14℃,while the positive culture rate declined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter H.pylori samples. 展开更多
关键词 CENTRALIZED ISOLATION HELICOBACTER PYLORI Influenc
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Diagnostic accuracy of endoscopic ultrasonography for rectal neuroendocrine neoplasms 预览
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作者 Hong-Tan Chen Guo-Qiang Xu +3 位作者 Xiao-Dong Teng Yi-Peng Chen Li-Hua Chen You-Ming Li 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2014年第30期10470-10477,共8页
AIM:To investigate the diagnostic accuracy of endoscopic ultrasonography(EUS)for rectal neuroendocrine neoplasms(NENs)and the differential diagnosis of rectal NENs from other subepithelial lesions(SELs).METHODS:The st... AIM:To investigate the diagnostic accuracy of endoscopic ultrasonography(EUS)for rectal neuroendocrine neoplasms(NENs)and the differential diagnosis of rectal NENs from other subepithelial lesions(SELs).METHODS:The study group consisted of 36 consecutive patients with rectal NENs histopathologically diagnosed using biopsy and/or resected specimens.The control group consisted of 31 patients with homochronous rectal non-NEN SELs confirmed by pathology.Epithelial lesions such as cancer and adenoma were excluded from this study.One EUS expert blinded to the histological results reviewed the ultrasonic images.The size,original layer,echoic intensity and homogeneity of the lesions and the perifocal structures were investigated.The single EUS diagnosis recorded by the EUS expert was compared with the histological results.RESULTS:All NENs were located at the rectum 2-10 cm from the anus and appeared as nodular(n=12),round(n=19)or egg-shaped(n=5)lesions with a hypoechoic(n=7)or intermediate(n=29)echo pattern and a distinct border.Tumors ranged in size from 2.3 to 13.7 mm,with an average size of 6.8 mm.Homogeneous echogenicity was seen in all tumors except three.Apart from three patients(stage T2 in two and stage T3 in one),the tumors were located in the second and/or third wall layer without involvement of the fourth and fifth layers.In the patients with stage T1 disease,the tumors were located in the second wall layer only in seven cases,the third wall layer only in two cases,and both the second and third wall layers in27 cases.Approximately 94.4%(34/36)of rectal NENs were diagnosed correctly by EUS,and 74.2%(23/31)of other rectal SELs were classified correctly as nonNENs.Eight cases of other SELs were misdiagnosed as NENs,including two cases of inflammatory lesions and one case each of gastrointestinal tumor,endometriosis,metastatic tumor,lymphoma,neurilemmoma,and hemangioma.The positive predictive value of EUS for rectal NENs was 80.9%(34/42),the negative predictive value was 92.0%(23/25),and the diagnostic accuracy wa 展开更多
关键词 RECTUM NEUROENDOCRINE NEOPLASMS ENDOSCOPIC ultraso
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Proteomic analysis of liver mitochondria from rats with nonalcoholic steatohepatitis 预览
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作者 Lin Li De-Zhao Lu +3 位作者 You-Ming Li Xue-Qun Zhang Xin-Xin Zhou Xi Jin 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2014年第16期4778-4786,共9页
AIM:To explore mitochondrial dysfunction in nonalcoholic steatohepatitis(NASH)by analyzing the proteome of liver mitochondria from a NASH model.METHODS:The NASH rat model was established by feeding rats a fat-rich die... AIM:To explore mitochondrial dysfunction in nonalcoholic steatohepatitis(NASH)by analyzing the proteome of liver mitochondria from a NASH model.METHODS:The NASH rat model was established by feeding rats a fat-rich diet for 24 wk and was confirmed using hematoxylin and eosin staining of liver tissue and by changes in the levels of serum alanine transaminase,aspartate aminotransferase,triglyceride,total cholesterol and other markers.Liver mitochondria from each group were isolated using differential centrifugation.The mitochondrial samples were lyzed,purified and further analyzed using two-dimensional electrophoresis combined with matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry.Bioinformatic analyses of assigned gene ontology and biological pathway was used to study functional enrichments in the abundant proteomic data.RESULTS:Eight up-regulated and sixteen down-regulated proteins were identified that showed greater than1.5-fold differences between the controls and the NASH group.These dysregulated proteins were predicted to be involved in different metabolic processes including fatty acidβ-oxidation processes,lipid metabolic processes,cell-cycle arrest,cell polarity maintenance,and adenosine triphosphate/sex hormone metabolic processes.Novel proteins that may be involved in NASH pathogenesis including the trifunctional enzyme Hadha,thyroxine,prohibitin,aldehyde dehydrogenase ALDH1L2,UDP-glucuronosyltransferase 2B31,and carbamoyl-phosphate synthase were identified using bioinformatics tools.The decreased expression of Hadha in NASH liver was verified by Western blotting,which was used as a complementary technique to confirm the proteomic results.CONCLUSION:This novel report on the liver mitochondrial proteome of a NASH model may provide a reservoir of information on the pathogenesis and treatment of NASH. 展开更多
关键词 NONALCOHOLIC STEATOHEPATITIS Hadha PROTEOMICS RAT
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Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease 预览 被引量:1
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作者 Xue-Qun Zhang Cheng-Fu Xu +2 位作者 Chao-Hui Yu Wei-Xing Chen You-Ming Li 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2014年第7期1768-1776,共9页
Nonalcoholic fatty liver disease(NAFLD)has emerged as a common public health problem in recent decades.However,the underlying mechanisms leading to the development of NAFLD are not fully understood.The endoplasmic ret... Nonalcoholic fatty liver disease(NAFLD)has emerged as a common public health problem in recent decades.However,the underlying mechanisms leading to the development of NAFLD are not fully understood.The endoplasmic reticulum(ER)stress response has recently been proposed to play a crucial role in both the development of steatosis and progression to nonalcoholic steatohepatitis.ER stress is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed due to the accumulation of unfolded or misfolded proteins.However,delayed or insufficient responses to ER stress may turn physiological mechanisms into pathological consequences,including fat accumulation,insulin resistance,inflammation,and apoptosis,all of which play important roles in the pathogenesis of NAFLD.Therefore,understanding the role of ER stress in the pathogenesis of NAFLD has become a topic of intense investigation.This review highlights the recent findings linking ER stress signaling pathways to the pathogenesis of NAFLD. 展开更多
关键词 Endoplasmic reticulum STRESS Unfolded PROTEIN resp
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Effects of pentoxifylline on nonalcoholic fatty liver disease: A meta-analysis 预览 被引量:2
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作者 Juan Du Yan-Yan Ma +1 位作者 Chao-Hui Yu You-Ming Li 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2014年第2期569-577,共9页
AIM:To evaluate the effects of pentoxifylline therapy in patients with nonalcoholic fatty liver disease(NAFLD).METHODS:We searched PubMed,Medline,Google Scholar,Embase,Web of Science,the Cochrane Library and the Chine... AIM:To evaluate the effects of pentoxifylline therapy in patients with nonalcoholic fatty liver disease(NAFLD).METHODS:We searched PubMed,Medline,Google Scholar,Embase,Web of Science,the Cochrane Library and the Chinese Biomedicine Database for all relevant controlled trials of pentoxifylline in patients with NAFLD from 1997 to July 2013.Five studies(3 randomized,double-blind,placebo-controlled trials and 2 prospective cohort studies with concurrent controls)were included in this meta-analysis.Statistical analysis was performed using RevMan 5.0 software.RESULTS:Five randomized trials of 147 patients with NAFLD/nonalcoholic steatohepatitis(NASH)were included.The results showed that compared to placebo,pentoxifylline therapy resulted in a signi?cant decrease in body weight(P=0.04),alanine aminotransferase (P<0.00001),aspartate transaminase(P=0.0006),glucose(P=0.0008)and tumor necrosis factor-α(P=0.007),but did not significantly affect body mass index(P=0.28),total cholesterol(P=0.80),triglyceride(P=0.98),alkaline phosphatase(P=0.29),γ-glutamyl transferase(P=0.39)and interleukin-6(P=0.38).With regard to histological changes,pentoxifylline only reduced the NAFLD activity score(P<0.00001)and improved lobular inflammation(P<0.0001).Improvements in steatosis grade(P=0.11),ballooning(P=0.10)and fibrosis(P=0.50)were not obvious.CONCLUSION:Pentoxifylline therapy results in weight loss,improved liver function and histological changes in patients with NAFLD/NASH.Therefore,pentoxifylline may be a new treatment option for NAFLD. 展开更多
关键词 PENTOXIFYLLINE NONALCOHOLIC FATTY LIVER DISEASE No
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Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study 预览
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作者 Ping Xu Cheng-fu Xu +5 位作者 Xing-yong Wan Chao-hui yu Chao Shen Peng Chen Gen-yun Xu You-ming Li 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2014年第33期11865-11870,共6页
AIM: To investigate the association between serum alpha-fetoprotein(AfP) levels and fatty liver disease(fLD) in a Chinese population.METHODS: A cross-sectional study was performed among subjects who presented for a he... AIM: To investigate the association between serum alpha-fetoprotein(AfP) levels and fatty liver disease(fLD) in a Chinese population.METHODS: A cross-sectional study was performed among subjects who presented for a health examination at the First Affiliated Hospital, College of Medicine, Zhejiang University in 2013. fLD was diagnosed based onan ultrasonography examination. Serum AfP levels were measured with a chemiluminescence immunoassay.RESULTS: Of the 9800 subjects enrolled, 2601 were diagnosed with fLD. Subjects with fLD had higher serum AfP levels than those without the disease. Subjects with high serum AfP levels had a higher prevalence of fLD, metabolic syndrome, and its components. Univariate logistic analysis showed that elevated serum AfP levels were associated with an increased risk of fLD(OR = 1.057, 95%CI: 1.031-1.084). however, after adjusting for covariates, AFP no longer remained significantly associated with the risk factors for fLD. CONCLUSION: Our results suggest that serum AfP levels are significantly associated with fLD and that AfP acts as a cofactor, but not as an independent factor, for fLD. 展开更多
关键词 FATTY LIVER ALPHA-FETOPROTEIN ASSOCIATION OBESITY
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Clonal immunoglobulin heavy chain and T-cell receptor γ gene rearrangements in primary gastric lymphoma 预览
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作者 Guo-Dong Shan Feng-Ling Hu +6 位作者 Ming Yang Hong-Tan Chen Wen-Guo Chen Yun-Gui Wang Li-Hua Chen You-Ming Li Guo-Qiang Xu 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第34期5727-5731,共5页
AIM:To study the diagnostic value of immunoglobulin heavy chain(IgH)and T-cell receptorγ (TCR-γ)gene monoclonal rearrangements in primary gastric lymphoma(PGL).METHODS:A total of 48 patients with suspected PGL at o... AIM:To study the diagnostic value of immunoglobulin heavy chain(IgH)and T-cell receptorγ (TCR-γ)gene monoclonal rearrangements in primary gastric lymphoma(PGL).METHODS:A total of 48 patients with suspected PGL at our hospital were prospectively enrolled in this study from January 2009 to December 2011.The patients were divided into three groups(a PGL group,a gastric linitis plastica group,and a benign gastric ulcer group)based on the pathological results(gastric mucosal specimens obtained by endoscopy or surgery)and follow-up.Endoscopic ultrasonography(EUS)and EUSguided biopsy were performed in all the patients.The tissue specimens were used for histopathological examination and for IgH and TCR-γ gene rearrangement polymerase chain reaction analyses.RESULTS:EUS and EUS-guided biopsy were successfully performed in all 48 patients.In the PGL group(n=21),monoclonal IgH gene rearrangements were detected in 14(66.7%)patients.A positive result for each set of primers was found in 12(57.1%),8(38.1%),and 4(19.0%)cases using FR1/JH,FR2/JH,and FR3/JH primers,respectively.Overall,12(75%)patients with mucosal-associated lymphoid tissue lymphoma(n=16)and 2(40%)patients with diffuse large B-cell lymphoma(n=5)were positive for monoclonal IgH gene rearrangements.No patients in the gastric linitis plastica group(n=17)and only one(10%)patient in the benign gastric ulcer group(n=10)were positive for a monoclonal IgH gene rearrangement.No TCRgene monoclonal rearrangements were detected.The sensitivity of monoclonal IgH gene rearrangements was 66.7%for a PGL diagnosis,and the specificity was96.4%.In the PGL group,8(100%)patients with stage IIE PGL(n=8)and 6(46.1%)patients with stage IE PGL(n=13)were positive for monoclonal IgH gene rearrangements.CONCLUSION:IgH gene rearrangements may be associated with PGL staging and may be useful for the diagnosis of PGL and for differentiating between PGL and gastric linitis plastica. 展开更多
关键词 IMMUNOGLOBULIN heavy chain T-CELL receptor γ Gene REARRANGEMENT Primary gastric lymphoma Endoscopic BIOPSY specimen
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Effects of probiotics on nonalcoholic fatty liver disease:A meta-analysis 预览 被引量:9
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作者 Yan-Yan Ma Lin Li +3 位作者 Chao-Hui Yu Zhe Shen Li-Hua Chen You-Ming Li 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第40期6911-6918,共8页
AIM:To investigate the relationship between the gutliver axis and nonalcoholic fatty liver disease(NAFLD),we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD.METHODS:We searched PubMed,... AIM:To investigate the relationship between the gutliver axis and nonalcoholic fatty liver disease(NAFLD),we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD.METHODS:We searched PubMed,Medline,Embase,Web of Science,the Cochrane Library and Chinese Biomedicine Database for all relevant randomized controlled trials on probiotics in patients with NAFLD/nonalcoholic steatohepatitis(NASH).A statistical analysis was performed using RevMan 5.0 software.RESULTS:Four randomized trials involving 134 NAFLD/NASH patients were included.The results showed that probiotic therapy signifcantly decreased alanine aminotransferase(ALT),aspartate transaminase(AST),total-cholesterol(T-chol),high density lipoprotein(HDL),tumor necrosis factor(TNF)-αand homeostasis model assessment of insulin resistance(HOMAIR)[ALT:weighted mean difference(WMD)-23.71,95%CI:-33.46--13.95,P【0.00001;AST:WMD-19.77,95%CI:-32.55--7.00,P=0.002;T-chol:WMD-0.28,95%CI:-0.55--0.01,P=0.04;HDL:WMD-0.09,95%CI:-0.16-0.01,P=0.03;TNF-α:WMD-0.32,95%CI:-0.48--0.17,P【0.0001;HOMA-IR:WMD-0.46,95%CI:-0.73--0.19,P=0.0008].However,the use of probiotics was not associated with changes in body mass index(BMI),glucose(GLU)and low density lipoprotein(LDL)(BMI:WMD 0.05,95%CI:-0.18-0.29,P=0.64;GLU:WMD 0.05,95%CI:-0.25-0.35,P=0.76;LDL:WMD-0.38,95%CI:-0.78-0.02,P=0.06).CONCLUSION:Probiotic therapies can reduce liver aminotransferases,total-cholesterol,TNF-αand improve insulin resistance in NAFLD patients.Modulation of the gut microbiota represents a new treatment for NAFLD. 展开更多
关键词 PROBIOTICS NONALCOHOLIC FATTY LIVER disease NONALCOHOLIC STEATOHEPATITIS LIVER function Insulin resistance META-ANALYSIS
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Potential role of Helicobacter pylori infection in nonalcoholic fatty liver disease 预览 被引量:1
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作者 Meng Li Zhe Shen You-Ming Li 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第41期7024-7031,共8页
Accumulating evidence has implicated Helicobacter pylori(H.pylori)infection in extragastrointestinal diseases,including obesity,type 2 diabetes mellitus,cardiovascular disease,and liver disease.Recently,there has bee... Accumulating evidence has implicated Helicobacter pylori(H.pylori)infection in extragastrointestinal diseases,including obesity,type 2 diabetes mellitus,cardiovascular disease,and liver disease.Recently,there has been a special focus on H.pylori infection as a risk factor for the development of nonalcoholic fatty liver disease(NAFLD).NAFLD is currently considered to be the most common liver disorder in western countries,and is rapidly becoming a serious threat to public health.The mechanisms of pathogenesis underlying NAFLD remain unclear at present and therapeutic options are limited.The growing awareness of the role of H.pylori in NAFLD is thus important to aid the development of novel intervention and prevention strategies,because the eradication of H.pylori is easy and much less expensive than long-term treatment of the other risk factors.H.pylori infection is involved in the pathogenesis of insulin resistance(IR),which is closely linked with NAFLD.It provides a new insight into the pathogenesis of NAFLD.This review probes the possible relationship between H.pylori and NAFLD,from the perspective of the potential mechanism of how H.pylori infection brings about IR and other aspects concerning this correlation. 展开更多
关键词 HELICOBACTER PYLORI NONALCOHOLIC FATTY liver disease INSULIN resistance Inflammation CYTOKINES
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Sonographic features of duodenal lipomas in eight clinicopathologically diagnosed patients 预览 被引量:2
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作者 Hong-Tan Chen Guo-Qiang Xu +2 位作者 Li-Jun Wang Yi-Peng Chen You-Ming Li 《世界胃肠病学杂志:英文版》 SCIE CAS CSCD 2011年第23期 2855-2859,共5页
瞄准:为十二指肠的脂肪瘤(DL ) 调查 sonographic 特征和内视镜的 ultrasonography (EUS ) 的诊断价值。方法:有病理地诊断的 DL 的八个连续病人的一个总数在学习被包括。一位 EUS 专家为所有损害考察了超声的图象,包括十二指肠的墙... 瞄准:为十二指肠的脂肪瘤(DL ) 调查 sonographic 特征和内视镜的 ultrasonography (EUS ) 的诊断价值。方法:有病理地诊断的 DL 的八个连续病人的一个总数在学习被包括。一位 EUS 专家为所有损害考察了超声的图象,包括十二指肠的墙,回响紧张和回响同质的原来的层。损害和 perifocal 结构的尺寸也被调查。由 EUS 的诊断与组织学的结果相比。结果:用平淡的内视镜检查法,仅仅一个案例正确地作为 DL 被诊断。四个案例作为 submucosal 肿瘤被分类,并且三个案例被错认作 stromal 肿瘤。所有肿瘤与在 EUS 上从 submucosal 层发源的不同前面的边阶作为圆或卵形的集中的 hyperechoic 损害出现了。肿瘤在尺寸从 8 ~ 36 公里,与 16 公里的一种平均尺寸。除了在肿瘤内有管状的结构的,同类的 echogenicity 在所有情况中被看见。回响变细在五种情况中在肿瘤后面仅仅在区域被观察,并且它在以后的边阶阴暗或不可见的三种在情况中在内并且在肿瘤后面被观察。七(87.5%) 案例正确地作为 DL 被诊断,并且(12.5%) 作为由 EUS 的 Brunners 腺腺瘤错误。病理地,所有肿瘤从 submucosal 层发源并且没有 heteromorphism,由成熟胖房间组成了。在胖房间之中,有渗入淋巴细胞,和丰富的含纤维的结缔组织的厚墙的容器的小数量。结论:在 EUS 上, DL 与显著回响变细并且没有 mucosa 的参与作为集中的同类的 hyperechoic submucosal 损害被展示。 展开更多
关键词 脂肪细胞 十二指肠 声像图 特征 患者 超声图像 诊断价值 确诊
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Effects of appendectomy and oral tolerance on dextran sulfate sodium colitis 预览 被引量:1
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作者 Min Yue Zhe Shen Chao-Hui Yu Hua Ye Yue-Fang Ye You-Ming Li 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2011年第19期2437-2445,共9页
瞄准:在大肠炎上评估阑尾切除术和口头的忍耐的伴随物效果。方法:在在正常和大肠炎下面的 ovalbumin (卵) 管理和免疫在 appendectomized 或假冒操作老鼠调节以后,延期类型超敏性(DTH ) 在 7-d 间隔被调查。为冒号的病理学的分数在... 瞄准:在大肠炎上评估阑尾切除术和口头的忍耐的伴随物效果。方法:在在正常和大肠炎下面的 ovalbumin (卵) 管理和免疫在 appendectomized 或假冒操作老鼠调节以后,延期类型超敏性(DTH ) 在 7-d 间隔被调查。为冒号的病理学的分数在提取冒号的蛋白质(CEP ) 和葡聚糖硫酸盐的正式就职的摄取以后被分级在 appendectomized 或假冒操作老鼠的钠(决策支持系统) 大肠炎。此后,在 Peyers 补丁和怒气淋巴细胞的 Th1 和 Th2 在对待的对待 CEP 、牛的浆液白朊(BSA ) 被检测控制老鼠。结果:在 appendectomized 老鼠, DTH 没在在卵管理以后并且在决策支持系统大肠炎的起始的阶段的白天 7 点被禁止,而它在白天 14 和白天 21 点被禁止。在假冒操作老鼠,然而,它在整个过程和决策支持系统大肠炎的发作期间被禁止。对决策支持系统大肠炎的 CEP 的保护的角色在假冒操作老鼠是在场的,与结肠的病理学的变化的占优势的改进,当消失在 appendectomized 老鼠时。到在 Peyers 补丁的 Th2 的从 Th1 的移动与 CEP 的摄取源于 Th1 房间的减少。与在假冒操作组的 BSA 相比,没有占优势的变化在 appendectomized 老鼠被观察。结论:阑尾切除术在口头的忍耐正式就职期间从 Th2 经由移动在决策支持系统大肠炎防碍 CEP 的保护的角色到 Th1。 展开更多
关键词 结肠炎 硫酸钠 葡聚糖 耐受 口服 脾淋巴细胞 尾和 牛血清白蛋白
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A study of the efficacy of bacterial biofilm cleanout for gastrointestinal endoscopes 预览 被引量:5
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作者 Fang, Ying Shen, Zhe +6 位作者 Li, Lan Cao, Yong Gu, Li-Ying Gu, Qing Zhong, Xiao-Qi Yu, Chao-Hui Li, You-Ming 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2010年第8期共6页
AIM:To compare the influence and clearance effect of enzymatic and non-enzymatic detergents against Escherichia coli (E. coli) biofilm on the inner surface of gastroscopes.METHODS:Teflon tubes were incubated in a mixt... AIM:To compare the influence and clearance effect of enzymatic and non-enzymatic detergents against Escherichia coli (E. coli) biofilm on the inner surface of gastroscopes.METHODS:Teflon tubes were incubated in a mixture of different detergents and E. coli culture (106 CFU/mL) for 72 h at 15℃,and biofilms on the inner surface of the teflon tubes were analyzed by bacterial count and scanning electron microscopy. To evaluate the clear-ance effect of detergents,after biofilms were formed on the inner surface o... 展开更多
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Early mortality of alcoholic hepatitis: A review of data from placebo-controlled clinical trials 预览 被引量:1
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作者 Yu, Chao-Hui Xu, Cheng-Fu +2 位作者 Ye, Hua Li, Lan Li, You-Ming 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2010年第19期共5页
AIM: To investigate the early mortality of placebo-treated alcoholic hepatitis patients. METHODS: Mortality data about alcoholic hepatitis patients who participated in randomized placebo-controlled trials were searche... AIM: To investigate the early mortality of placebo-treated alcoholic hepatitis patients. METHODS: Mortality data about alcoholic hepatitis patients who participated in randomized placebo-controlled trials were searched from PubMed, EMBASE, and Cochrane Library, extracted and analyzed. RESULTS: A total of 661 placebo-treated patients in 19 trials were included. The overall mortality rate was 34.19% with a median observation time of 160 d (range 21-720 d). Hepatic failure, gastrointestinal bleeding and infect... 展开更多
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