基金The authors are grateful to Dr. Xiaojiang Hao and ProL Shoei-Sheng Lee for their encouragement on this research topic. We thank Junjun Xu for technical assistances. The authors appreciate Dr. F. Guéritte and Prof. J. Stoeckigt for useful discussions. 0ne of the authors （Y. Zhao） would also like to express his thanks to the Chinese Ministry of Education as well as to Mr. Ka-shing Li for the ＂Cheung Kong Professorship＂ at Zhejiang University.
文摘23 compounds containing pyranone pharmaeophore of territrem B were designed and synthesized. Some of the analogues showed IC50 values of AChE inhibition at 10-5 mol/L.