期刊文献+
共找到165,238篇文章
< 1 2 250 >
每页显示 20 50 100
Redox,immune and genetic biomarker system for personalized treatments in colorectal cancer 预览
1
作者 Anna Maria Berghella Anna Aureli +3 位作者 Angelica Canossi Tiziana Del Beato Alessia Colanardi Patrizia Pellegrini 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第2期117-138,共22页
BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC)onset that could improve clinical strategies.AIM To determine valid targets and a predictiv... BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC)onset that could improve clinical strategies.AIM To determine valid targets and a predictive biomarker’s system of chronicization of inflammation for cancer treatment.METHODS A group of 147 CRC patients was studied.Clinical diagnosis was confirmed histopathologically,and patients were sub-typed using the pathological tumornode-metastasis classification.Thirteen colon adenoma patients and 219 healthy subjects were also studied.A system biology study on Thioredoxin1/CD30 redox-immune systems(Trx1/CD30),T helper cytokines and polymorphisms of killer immunoglobulin-like receptors,FcγRIIa-131H/R and FcγRIIIa-158V/F was carried out.Enzyme-linked immunosorbent assay was performed to analyze sera.Genetic study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method.Statistical analysis was performed by using the“Statgraphics software systems”.RESULTS We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age.With respect to the gender relationships,there were distinct differences.Females showed a primary relationship between transforming growth factor beta(TGFβ)with Trx1,whereas males had one with TGFβand RTrx1.Trx1/CD30 controls the redox immune homeostasis,and an imbalance in the relationship between the Trx1/RTrx1 and sCD30 levels is linked to the onset and progression of tumor.This event happens through different gender-specific cytokine pathways.Our study demonstrated that the serum levels of Trx1/RTrx1,TGFβ/interleukin(IL)6 and TGFβ/IL4 combinations and the sCD30,IFNγand IL2 combination constitute a predictive gender specific biomarker system.This is relevant for clinical screening to detect the risk of the potential development or progression of a tumor.CONCLUSION Oxidative stress on Trx1/CD30 is a trigger of cancer disease,and the selected oxidation and immune products are a biomarker system for aging a 展开更多
关键词 AGING and CANCER BIOMARKER CANCER personalized treatments Oxidation and IMMUNE biomarkers Trx1/CD30 target KIRs and FCΓR polymorphisms Th cytokines AGING and disease Cancer-related mechanisms
在线阅读 免费下载
碳离子治疗恶性肿瘤研究进展
2
作者 陈威佐 唐君霞 +2 位作者 赵达 关泉林 潘婷婷 《中国肿瘤》 CAS CSCD 北大核心 2019年第3期208-213,共6页
碳离子束放射治疗因其精确的剂量分布、理想的生物效应及动态束流监控等优点,在强力杀伤肿瘤的同时可明显降低对正常组织的损伤及缩减治疗时间,对腺样囊性癌、骨肉瘤、软骨肉瘤、肝细胞肝癌等的治疗疗效被广泛认可,该项技术在德国、日... 碳离子束放射治疗因其精确的剂量分布、理想的生物效应及动态束流监控等优点,在强力杀伤肿瘤的同时可明显降低对正常组织的损伤及缩减治疗时间,对腺样囊性癌、骨肉瘤、软骨肉瘤、肝细胞肝癌等的治疗疗效被广泛认可,该项技术在德国、日本等国家发展较迅速,我国目前正处于临床试验阶段。文章就碳离子治疗肿瘤的原理、优势及临床研究现状进行综述。 展开更多
关键词 碳离子束 恶性肿瘤 肺癌 肝癌 放射治疗
Photodynamic therapy as salvage therapy for residual microscopic cancer after ultra-low anterior resection: A case report 预览
3
作者 Si-Qi Zhang Kui-Jie Liu +5 位作者 Hong-Liang Yao San-Lin Lei Zhen-Dong Lei Wen-Jun Yi Li Xiong Hua Zhao 《世界临床病例杂志》 2019年第6期798-804,共7页
BACKGROUND The rate of positive resection margins (R1) in patients with low rectal cancer is substantial. Recommended remedies such as extended resection or chemoradiotherapy have their own serious drawbacks. It has b... BACKGROUND The rate of positive resection margins (R1) in patients with low rectal cancer is substantial. Recommended remedies such as extended resection or chemoradiotherapy have their own serious drawbacks. It has been reported that photodynamic therapy (PDT) as a remedial treatment for esophageal cancer. Colorectal cancer and esophageal cancer has many similarities, however, PDT as a salvage therapy for rectal cancer is rare. CASE SUMMARY Here, we describe a 56-year-old man who was admitted to the hospital due to a 6- mo history of hemafecia, which had been aggravated for 1 mo. Colonoscopy revealed a 3 × 4 cm ulcerated mass in the rectum 4 cm from the anus. Preoperative pathological examination showed villous adenoma, moderate-tohigh- grade dysplasia, good differentiation, and invasion of the mucosal muscle. The patient had R1 after ultra-low anterior resection, but he refused extended resection and experienced severe liver function impairment after 3 cycles of chemotherapy. Ultimately, the patient underwent PDT to remove R1. After five years of follow-up, there was no liver function impairment, recurrence, metastasis, sexual dysfunction, or abnormal defecation function. CONCLUSION This is the first case worldwide in which R1 of rectal cancer were successfully treated by PDT. 展开更多
关键词 Low rectal CANCER Photodynamic THERAPY Positive MICROSCOPIC DISTAL margin SALVAGE THERAPY Removal RESIDUAL MICROSCOPIC CANCER Case report
在线阅读 免费下载
营卫失常与癌病病机相关性研究
4
作者 丁元庆 《山东中医杂志》 2019年第1期9-13,共5页
探讨营卫特别是卫气失常在癌病发生过程中的病机转变以及防治中的作用,旨在阐明防治癌病的理论基础。①营卫特别是卫气失常与癌病发生关系密切,营卫失去防御能力,是导致癌自内生的发病基础;同时,营卫还是癌赖以在体内生存的基础。②通... 探讨营卫特别是卫气失常在癌病发生过程中的病机转变以及防治中的作用,旨在阐明防治癌病的理论基础。①营卫特别是卫气失常与癌病发生关系密切,营卫失去防御能力,是导致癌自内生的发病基础;同时,营卫还是癌赖以在体内生存的基础。②通常癌病难治,但可预防。导致癌病的原因众多,其中不健康生活方式位列诸因之首,因而保持健康生活方式,避免或减少营卫损伤,是预防癌病的基本条件。未病之先,增强体质以期预防癌病;既病之后,强壮身体则是治愈癌病或带病延年的基础。③营卫因不良生活方式而损伤,癌病因营卫损伤自内而生,据此提出通调营卫是癌病防治的指导思想。 展开更多
关键词 营卫失常 癌症 癌病 病因病机 通调营卫 癌病可防
2015年上海市恶性肿瘤流行特征分析 预览
5
作者 鲍萍萍 吴春晓 +9 位作者 张敏璐 彭鹏 王春芳 龚杨明 顾凯 向詠梅 施亮 庞怡 施燕 付晨 《中国癌症杂志》 CAS CSCD 北大核心 2019年第2期81-99,共19页
背景与目的:恶性肿瘤严重威胁着居民健康,已成为重大的公共卫生问题。本研究旨在描述和分析2015年上海市恶性肿瘤流行特征。方法:根据上海市恶性肿瘤病例报告登记系统收集的恶性肿瘤发病和死亡资料,按地区、性别分层,分别计算恶性肿瘤... 背景与目的:恶性肿瘤严重威胁着居民健康,已成为重大的公共卫生问题。本研究旨在描述和分析2015年上海市恶性肿瘤流行特征。方法:根据上海市恶性肿瘤病例报告登记系统收集的恶性肿瘤发病和死亡资料,按地区、性别分层,分别计算恶性肿瘤发病与死亡粗率、标化率、前10位恶性肿瘤发病与死亡顺位和构成等,并应用Joinpoint统计软件分析2002—2015年上海市肺癌发病和死亡趋势,估算总体和分阶段的年度变化百分比(annual percent change,APC)。采用Segi’s世界标准人口年龄构成计算标化率。结果:2015年上海市共报告恶性肿瘤新发病例71 610例,死亡病例38 445例。病理学诊断比例(percentage of morphologically verified cases,MV%)为78.42%,只有死亡医学证明书比例(percentage of death certifications only,DCO%)为0.21%,死亡发病比(mortality to incidence ratio,M/I)为0.55。上海市恶性肿瘤粗发病率为497.33/10万,标化发病率为228.82/10万,男性标化发病率低于女性,市区低于郊区。恶性肿瘤发病在40岁以后快速上升,在80~84岁年龄组达到高峰。全市发病前10位恶性肿瘤依次为肺癌、结直肠癌、甲状腺癌、胃癌、乳腺癌、肝癌、前列腺癌、胰腺癌、脑和中枢神经系统肿瘤以及膀胱癌,前10位恶性肿瘤占全部恶性肿瘤发病的76.59%。全市恶性肿瘤粗死亡率为267.00/10万,标化死亡率为95.99/10万,男性标化死亡率高于女性,市区和郊区基本持平。死亡率在45岁以后快速上升,在≥85岁年龄组达到高峰。死亡前10位恶性肿瘤依次为肺癌、结直肠癌、胃癌、肝癌、胰腺癌、乳腺癌、食管癌、胆囊癌、前列腺癌以及脑和中枢神经系统肿瘤,前10位恶性肿瘤占全部恶性肿瘤死亡的78.07%。截至2016年12月31日,上海市共有399 027例现患肿瘤病例,现患率为2.77%。市区现患率为3.07%,郊区为2.55%。乳腺癌是现患病例中最常见的恶性肿瘤,占15.33%。� 展开更多
关键词 恶性肿瘤 发病率 死亡率 趋势 肺癌
在线阅读 下载PDF
Prospects for immunotherapy as a novel therapeutic strategy against hepatocellular carcinoma 预览
6
作者 Yu Akazawa Toshihiro Suzuki +3 位作者 Toshiaki Yoshikawa Shoichi Mizuno Yasunari Nakamoto Tetsuya Nakatsura 《世界荟萃分析杂志》 2019年第3期80-95,共16页
Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, with a poor clinical prognosis. Many standard therapies are often considered for HCC treatment today;however, these conventional therapies often... Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, with a poor clinical prognosis. Many standard therapies are often considered for HCC treatment today;however, these conventional therapies often fail to achieve sufficiently effective clinical results. Today, HCC therapy is set to undergo a major revolution, owing to rapid developments in cancer immunotherapy, particularly immune checkpoint inhibitor therapy. Cancer immunotherapy is a novel and promising treatment strategy that differs significantly from conventional therapies in its approach to achieve antitumor effects. In fact, many cancer immunotherapies have been tested worldwide and shown to be effective against various types of cancer;HCC is no exception to this trend. For example, we identified a specific cancer antigen called glypican-3 (GPC3) and performed clinical trials of GPC3-targeted peptide vaccine immunotherapy in patients with HCC. Here, we present an overview of the immune mechanisms for development and progression of HCC, our GPC3-based immunotherapy, and immune checkpoint inhibitor therapy against HCC. Finally, we discuss the future prospects of cancer immunotherapy against HCC. We believe that this review and discussion of cancer immunotherapy against HCC could stimulate more interest in this promising strategy for cancer therapy and help in its further development. 展开更多
关键词 Hepatocellular carcinoma CANCER IMMUNOTHERAPY Immune CHECKPOINT inhibitor GLYPICAN-3 CANCER vaccine Clinical trials CYTOTOXIC T-LYMPHOCYTES
在线阅读 免费下载
DNA甲基转移酶3B-149C>T多态性与致癌风险相关性的Meta分析 预览
7
作者 吴雯 李萍 +5 位作者 左然 曾庆波 吴德生 谢妮 龙鼎新 袁建辉 《癌变.畸变.突变》 CAS 2019年第2期102-110,共9页
目的:评估DNA甲基转移酶3B-149C>T(DNMT3B-149C>T)多态性与致癌风险之间的相关性。方法:依据Newcastle-Ottawa Scale(NOS)文献质量评价量表,对1990~2017年国内外公开发表的相关文献进行评价并提取资料;对DNMT3B-149C>T各基因... 目的:评估DNA甲基转移酶3B-149C>T(DNMT3B-149C>T)多态性与致癌风险之间的相关性。方法:依据Newcastle-Ottawa Scale(NOS)文献质量评价量表,对1990~2017年国内外公开发表的相关文献进行评价并提取资料;对DNMT3B-149C>T各基因型模型进行比较,包括CC与TT、CT与TT、CC+CT与TT,综合分析其在病例组和对照组中的分布情况;通过Q检验和I^2值分析各研究间的异质性,应用Begg秩相关法和Egger回归法验证发表偏倚,使用Review Manager 5.0软件和STATA version 12.0进行统计分析,计算比值比(OR)及95%置信区间(95%CI),评估DNMT3B-149C>T多态性与致癌风险的相关性。结果:分析文献中的7612名癌症病例和9679名健康对照。按不同癌症类型进行亚组分析,DNMT3B-149C>T多态性与肺癌的患病存在相关性[OR=1.51,95%CI(1.08,2.12),P=0.02]。结论:DNMT3B-149C>T多态性可能是肺癌的易感性因素。 展开更多
关键词 DNA甲基转移酶3B 单核苷酸多态性 癌症 META分析 肺癌
在线阅读 下载PDF
Hong Kong female’s breast cancer awareness measure: Crosssectional survey 预览
8
作者 May Pui Shan Yeung Emily Ying Yang Chan +2 位作者 Samuel Yeung Shan Wong Benjamin Hon Kei Yip Polly Suk-Yee Cheung 《世界临床肿瘤学杂志(英文版)》 2019年第2期98-109,共12页
BACKGROUND In women worldwide, breast cancer is the most common cancer. Breast cancer accounted for 26.6% of all new cancers in females diagnosed in 2015 in Hong Kong. AIM To examine women’s awareness, perception, kn... BACKGROUND In women worldwide, breast cancer is the most common cancer. Breast cancer accounted for 26.6% of all new cancers in females diagnosed in 2015 in Hong Kong. AIM To examine women’s awareness, perception, knowledge, and screening practice of breast cancer in Hong Kong. METHODS We carried out a population-based survey using random telephone interviews to women aged 18 or above using the United Kingdom Cancer Research Breast Cancer Awareness Measure (United Kingdom CAM). The data was analysed using proportions, chi-square test (χ2-test) and adjusted odds ratios (ORs). RESULTS A total of 1000 participants completed the CAM questionnaire from 1,731 responses (response rate = 57.8%) from September to October 2017. One in five and one in four respondents recalled ≥ 3 early warning signs and ≥ 2 risk factors of breast cancer respectively. The majority (62.6%) reported they were not confident that they would notice a change in their breasts. Among the respondents, 16.8% would have regular mammography at least every two years.In general, 4 in 10 women had tried practices on preventing breast cancer. Respondents with better result in recalling breast cancer signs and symptoms were more likely to seek immediate medical help when noticed a change in their breasts (χ^2-test P = 0.038), and more likely had tried prevention practice (χ^2-test P < 0.001). Respondents received higher education (secondary school or above) had higher breast cancer awareness (OR = 2.83, CI: 1.61-4.97), more frequent screening (OR = 2.64, CI: 1.63-4.26) and more had tried prevention practices (OR = 2.80, CI: 1.96-4.02) when compared to those with lower education. Those in age groups 31- 45 and 46-60 had higher percentages in performing breast self-exam and mammography when compared to the 18-30 and 61 or above age groups. CONCLUSION Population-wide public health initiatives should emphasize on prevention and early detection of breast cancer in women, with targeted strategy for those with low education level and advance in age. 展开更多
关键词 BREAST CANCER CANCER AWARENESS MEASURE AWARENESS Screening practice Behaviour ATTITUDE
在线阅读 免费下载
Small molecule activators of the p53 response
9
作者 Marcus J.G.W.Ladds Sonia Lain 《分子细胞生物学报:英文版》 SCIE CAS CSCD 2019年第3期245-254,共10页
Drugging the p53 pathway has been a goal for both academics and pharmaceutical companies since the designation of p53 as the'guardian of the genome'.Through growing understanding of p53 biology,we can see mult... Drugging the p53 pathway has been a goal for both academics and pharmaceutical companies since the designation of p53 as the'guardian of the genome'.Through growing understanding of p53 biology,we can see multiple routes for activation of both wild-type p53 function and restoration of mutant p53?In this review,we focus on small molecules that activate wild-type p53 and that do so in a nongenotoxit manner.In particular,we will describe potential approaches to targeting proteins that alter p53 stability and function through posttranslational modification,affect p53's subcellular localization,or target RNA synthesis or the synthesis of ribonucleotides.The plethora of pathways for exploitation of p53,as well as the wide-ranging response to p53 activation,makes it an attractive target for anti-cancer therapy. 展开更多
关键词 CANCER P53 small MOLECULE cell BIOLOGY CANCER THERAPY
益气养阴解毒方辅助厄洛替尼靶向治疗对晚期非小细胞肺癌患者血清糖类抗原199、环氧化酶2和免疫功能的影响 预览
10
作者 吴春晓 缪佳 《河北中医》 2019年第2期238-242,共5页
目的 观察益气养阴解毒方辅助厄洛替尼靶向治疗对晚期非小细胞肺癌(NSCLC)患者血清糖类抗原199(CA199)、环氧化酶-2(COX-2)和免疫功能的影响。方法 将86例晚期NSCLC患者按照随机数字表法分为2组。对照组43例采用厄洛替尼靶向治疗;治疗... 目的 观察益气养阴解毒方辅助厄洛替尼靶向治疗对晚期非小细胞肺癌(NSCLC)患者血清糖类抗原199(CA199)、环氧化酶-2(COX-2)和免疫功能的影响。方法 将86例晚期NSCLC患者按照随机数字表法分为2组。对照组43例采用厄洛替尼靶向治疗;治疗组43例在对照组治疗基础上加用益气养阴解毒方治疗。2组均持续治疗2个月。观察2组治疗前后中医证候改善情况及血清CA199、COX-2水平,外周血CD3^+、CD4^+、CD8^+、自然杀伤(NK)细胞比例和CD4^+/CD8^+值,比较2组临床疗效。结果 治疗组病情控制率(83.72%)高于对照组(62.79%, P <0.05),临床疗效优于对照组。治疗组中医证候改善总有效率(88.37%)高于对照组(69.77%, P <0.05)。治疗后2组血清CA199、COX-2水平均较本组治疗前明显降低( P <0.05),且治疗组低于对照组( P <0.05)。治疗后治疗组CD3^+、CD4^+、NK细胞比例及CD4^+/CD8^+均较本组治疗前升高( P <0.05),CD8^+比例明显降低( P <0.05),且与对照组治疗后比较差异均有统计学意义( P <0.05)。结论 益气养阴解毒方配合厄洛替尼靶向治疗有助于提高晚期NSCLC患者治疗效果,降低血清CA199、COX-2水平,改善免疫功能。 展开更多
关键词 非小细胞肺癌 益气养阴 中药疗法 抗原 肿瘤相关 碳水化合物 糖类抗原199 环氧化酶2 免疫功能
在线阅读 免费下载
肿瘤疫苗临床研究评价及进展
11
作者 黄芸 高建鹏 王辉 《肿瘤学杂志》 CAS 2019年第3期196-201,共6页
肿瘤疫苗是近年来肿瘤疾病的新兴治疗手段之一,其种类繁多,疗效显著,有着良好的应用前景。肿瘤疫苗可分为全细胞疫苗、多肽疫苗、基因工程疫苗和单克隆抗体疫苗等类别。2011~2017年间有15个肿瘤疫苗类新药获批上市,实现了基础研发到临... 肿瘤疫苗是近年来肿瘤疾病的新兴治疗手段之一,其种类繁多,疗效显著,有着良好的应用前景。肿瘤疫苗可分为全细胞疫苗、多肽疫苗、基因工程疫苗和单克隆抗体疫苗等类别。2011~2017年间有15个肿瘤疫苗类新药获批上市,实现了基础研发到临床应用的迈进,为肿瘤的治疗模式带来了令人振奋的变革。全文就近几年肿瘤疫苗领域的新药从分类、作用机制及临床应用进展方面作一综述。 展开更多
关键词 肿瘤 肿瘤疫苗 免疫治疗
The regulatory pathways leading to stem-like cells underlie prostate cancer progression
12
作者 Chun-Jung Lin U-Ging Lo Jer-Tsong Hsieh 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第3期233-240,共8页
Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surge... Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surgery and radiation. For patients with distant metastases, androgen deprivation therapy (ADT) is a gold standard. Regardless of a favorable outcome of ADT, patients inevitably relapse to an end-stage castration-resistant prostate cancer (CRPC) leading to mortality. Therefore, revealing the mechanism and identifying cellular components driving aggressive PCa is critical for prognosis and therapeutic intervention. Cancer stem cell (CSC) phenotypes characterized as poor differentiation, cancer initiation with self-renewal capabilities, and therapeutic resistance are proposed to contribute to the onset of CRPC. In this review, we discuss the role of CSC in CRPC with the evidence of CSC phenotypes and the possible underlying mechanisms. 展开更多
关键词 CANCER STEM cell CASTRATION-RESISTANT prostate CANCER NEUROENDOCRINE differentiation TRANSDIFFERENTIATION
Stereotactic body radiation therapy for non-small cell lung cancer:A review 预览
13
作者 Kavitha M Prezzano Sung Jun Ma +3 位作者 Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh 《世界临床肿瘤学杂志(英文版)》 2019年第1期14-27,共14页
Stereotactic body radiation therapy(SBRT)is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC).A literature search primarily based on PubMed electronic databas... Stereotactic body radiation therapy(SBRT)is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC).A literature search primarily based on PubMed electronic databases was completed in July 2018.Inclusion and exclusion criteria were determined prior to the search,and only prospective clinical trials were included.Nineteen trials from 2005 to 2018 met the inclusion criteria,reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC.Patient eligibility,prescription dose and delivery,and follow up duration varied widely.Threeyears overall survival ranged from 43%to 95%with loco-regional control of up to 98%at 3 years.Up to 33%of patients failed distantly after SBRT at 3 years.SBRT was generally well tolerated with 10%-30%grade 3-4 toxicities and a few treatment-related deaths.No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT,central and peripheral lung tumors,or inoperable and operable patients.SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC.SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery.Decreasing fractionation schedules have been consistently shown to be both safe and effective.Distant failure is common,and chemotherapy may be considered for select patients.However,the survival benefit of additional interventions,such as chemotherapy,for early stage NSCLC treated with SBRT remains unclear. 展开更多
关键词 LUNG CANCER NON-SMALL cell LUNG CANCER STEREOTACTIC body radiation therapy STEREOTACTIC ABLATIVE radiotherapy DISTANT failure
在线阅读 免费下载
Is irreversible electroporation safe and effective in the treatment of hepatobiliary and pancreatic cancers? 预览
14
作者 Li-Ming Wu Le-Le Zhang +1 位作者 Xin-Hua Chen Shu-Sen Zheng 《国际肝胆胰疾病杂志:英文版》 SCIE CAS CSCD 2019年第2期117-124,共8页
Background:Irreversible electroporation(IRE)is a novel ablative technique for hepatobiliary and pancreatic cancers.This review summarizes the data regarding the safety and efficacy of IRE in the treatment of hepatobil... Background:Irreversible electroporation(IRE)is a novel ablative technique for hepatobiliary and pancreatic cancers.This review summarizes the data regarding the safety and efficacy of IRE in the treatment of hepatobiliary and pancreatic cancers.Data sources:Studies were identified by searching PubMed and Embase for articles published in English from database inception through July 31,2017.For inclusion,each clinical study had to report morbidity and survival data on hepatobiliary and pancreatic cancers treated with IRE and contain at least 10 patients.Studies that met these criteria were included for analysis.Two authors assessed each clinical study for data extraction.The controversial parts were resolved through discussion with seniors.Results:A total of 24 clinical studies were included.Fourteen focused on hepatic ablation with IRE comprising 437 patients with 666 lesions of different tumor types.Two patients(0.5%)died after the IRE procedure.Morbidity of hepatic ablation with IRE ranged from 7%to 35%.Most complications were mild.Complete response for hepatic tumors was reported as 57%–97%.Ten studies with 455 patients focused on pancreatic IRE.The overall mortality of IRE in pancreatic cancer was 2%.Overall severe morbidity of IRE in pancreatic cancer ranged from 0 to 20%.The median overall survival after IRE ranged from 7 to 23 months.Patients treated with IRE combined with surgical resection showed a longer overall survival.Conclusions:IRE significantly improves the prognosis of advanced hepatobiliary and pancreatic malignances,and companied with less complications.Hence,IRE is a relatively safe and effective non-thermal ablation strategy and potentially recommended as an option for therapy of patients with hepatobiliary and pancreatic malignances. 展开更多
关键词 IRREVERSIBLE ELECTROPORATION Hepatic CANCER PANCREATIC CANCER
在线阅读 下载PDF
Enhanced recovery after surgery protocol enhances early postoperative recovery after pancreaticoduodenectomy 预览
15
作者 Ramasamy Mahendran Mallika Tewari +1 位作者 Vinod Kumar Dixit Hari Shankar Shukla 《国际肝胆胰疾病杂志:英文版》 SCIE CAS CSCD 2019年第2期188-193,共6页
Background:Enhanced recovery after surgery(ERAS)protocol is a multimodal,multidisciplinary and evidence-based approach to reduce surgical stress and enhance recovery in the postoperative period.This study aimed to ana... Background:Enhanced recovery after surgery(ERAS)protocol is a multimodal,multidisciplinary and evidence-based approach to reduce surgical stress and enhance recovery in the postoperative period.This study aimed to analyze the outcome of ERAS protocol in patients after pancreaticoduodenectomy(PD).Methods:A total of 50 consecutive patients with pancreatic/periampullary cancer who underwent PD between January 2016 to August 2017 were included in the study.As per the institute ERAS protocol,nasogastric tube(NGT)was removed on postoperative day(POD)1 if output was less than 200 mL and oral sips were allowed;oral liquids were allowed on POD2;semisolid diet by POD3;abdominal drain was removed on POD 4 if output was less than 100 mL with no evidence of postoperative pancreatic fistula(POPF);normal diet was allowed on POD5.Discharge criteria on POD6 were afebrile,tolerating oral normal diet,pain free and no surgery related complications(defined as per the ISGPS definitions).Results:NGT was removed on POD1 in 45(90%)patients,abdominal drain removed by POD4 in 41(82%)and 43(86%)patients were discharged on POD6.There was no 30-day postoperative mortality.Three(6%)patients had delayed gastric emptying(DGE).None had postoperative hemorrhage and POPF.Readmission rate was 8%.A significant relation was found between the length of hospital stay(LOS)with age(P<0.05)and a marginal relation between LOS and postoperative albumin(P=0.05).Conclusions:ERAS protocol can be safely followed in the perioperative care of patients who undergo PD.Early removal of NGT and allowing oral diet restore bowel function early.ERAS decreases the LOS and postoperative complications. 展开更多
关键词 Enhanced RECOVERY PROTOCOL PANCREATIC CANCER Periampullary CANCER PANCREATICODUODENECTOMY Early DISCHARGE
在线阅读 下载PDF
Artificial intelligence system of faster region-based convolutional neural network surpassing senior radiologists in evaluation of metastatic lymph nodes of rectal cancer
16
作者 Lei Ding Guang-Wei Liu +11 位作者 Bao-Chun Zhao Yun-Peng Zhou Shuai Li Zheng-Dong Zhang Yu-Ting Guo Ai-Qin Li Yun Lu Hong-Wei Yao Wei-Tang Yuan Gui-Ying Wang Dian-Liang Zhang Lei Wang 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第4期379-387,共9页
Background: An artificial intelligence system of Faster Region-based Convolutional Neural Network (Faster R-CNN) is newly developed for the diagnosis of metastatic lymph node (LN) in rectal cancer patients. The primar... Background: An artificial intelligence system of Faster Region-based Convolutional Neural Network (Faster R-CNN) is newly developed for the diagnosis of metastatic lymph node (LN) in rectal cancer patients. The primary objective of this study was to comprehensively verify its accuracy in clinical use. Methods: Four hundred fourteen patients with rectal cancer discharged between January 2013 and March 2015 were collected from 6 clinical centers, and the magnetic resonance imaging data for pelvic metastatic LNs of each patient was identified by Faster R-CNN. Faster R-CNN based diagnoses were compared with radiologist based diagnoses and pathologist based diagnoses for methodological verification, using correlation analyses and consistency check. For clinical verification, the patients were retrospectively followed up by telephone for 36 months, with post-operative recurrence of rectal cancer as a clinical outcome;recurrence-free survivals of the patients were compared among different diagnostic groups, by methods of Kaplan-Meier and Cox hazards regression model. Results: Significant correlations were observed between any 2 factors among the numbers of metastatic LNs separately diagnosed by radiologists, Faster R-CNN and pathologists, as evidenced by rradiologist-Faster R-CNN of 0.912, rPathologist-radiologist of 0.134, and rPathologist-Faster R-CNN of 0.448 respectively. The value of kappa coefficient in N staging between Faster R-CNN and pathologists was 0.573, and this value between radiologists and pathologists was 0.473. The 3 groups of Faster R-CNN, radiologists and pathologists showed no significant differences in the recurrence-free survival time for stage N0 and N1 patients, but significant differences were found for stage N2 patients. Conclusion: Faster R-CNN surpasses radiologists in the evaluation of pelvic metastatic LNs of rectal cancer, but is not on par with pathologists. 展开更多
关键词 AI (Artificial Intelligence) Magnetic resonance imaging PATHOLOGY LYMPH NODES RECTAL cancer
STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression 预览
17
作者 Jian Wang Junling Shen +3 位作者 Kaili Zhao Jinmeng Hu Jiuxing Dong Jianwei Sun 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期100-108,共9页
Objective: Stromal interaction molecule 1(STIM1) overexpression has been reported to play an important role in progression of several cancers. However, the mechanism of STIM1 overexpression and its relationship with h... Objective: Stromal interaction molecule 1(STIM1) overexpression has been reported to play an important role in progression of several cancers. However, the mechanism of STIM1 overexpression and its relationship with hypoxia in pancreatic ductal adenocarcinoma(PDAC) remains unclear.Methods: STIM1 and HIF-1α expression was tested using immunohistochemistry in tissue microarray(TMA) including pancreatic cancer and matched normal pancreatic tissues, and their relationships with clinicopathological parameters were statistically analyzed. q-PCR, Western blot, Ch IP, and luciferase assay were employed to 030 analyze transcriptional regulation between HIF-1α and STIM1 in pancreatic cancer PANC-1 cells.Results: Both STIM1 and HIF-1α showed higher positive rates and up-regulated expression in cancer tissues compared to that of normal tissues(P < 0.05). The Kaplan–Meier method revealed that higher HIF-1α and STIM1 expression levels were significantly correlated with decreased disease-free survival(P = 0.025 and P = 0.029, respectively). The expression of HIF-1α showed a significant positive correlation with that of STIM1 in cancer tissues(rs = 0.3343, P = 0.0011) and pancreatic cancer cell lines.Furthermore, Ch IP and luciferase assays confirmed that HIF-1α bound to the STIM1 promoter and regulated its expression in PANC-1 cells.Conclusions: In hypoxia microenvironment, up-regulated expression of STIM1 mediated by HIF-1α promotes PDAC progression. HIF-1α and STIM1 are potential prognostic markers and/or therapeutic targets for PDAC treatment. 展开更多
关键词 PANCREATIC CANCER STIM1 HIF-1Α
在线阅读 下载PDF
Preoperative Short-Course Radiation Therapy in Rectal Cancer 预览
18
作者 Pham Nguyen Tuong Pham Nguyen Cuong +2 位作者 Le Trong Hung Nguyen Thanh Ai Huynh Thanh Hai 《美中医学:英文版》 2019年第2期100-104,共5页
Purpose:To evaluate the benefits of preoperative short-course radiotherapy in locally advanced rectal cancer.Patients and methods:A prospective study of 30 rectal cancer patients at T3-4M0 stage and ECOG 0-2 performed... Purpose:To evaluate the benefits of preoperative short-course radiotherapy in locally advanced rectal cancer.Patients and methods:A prospective study of 30 rectal cancer patients at T3-4M0 stage and ECOG 0-2 performed preoperative short-course radiation therapy at Hue Central Hospital Vietnam between June 2016 and July 2018,using pelvic 3D-Conformal Radiation Therapy with the total radiation dose being 25 Gy in 5 fractions over five days.Results:Mean age 57.1±13.6 with 46.7%of patients in the range of 41-60 year-old.Male/female ratio:2/1.Tumour stage T3 and T4 was 70%and 30%,respectively;stage III and stage IV was 86.7%and 13.3%,respectively.Positive lymph node rates on endoscopic ultrasound were 85.7%in T3 and 77.8%in T4.Downstaging rate for stage III,T4 and T3 was 65.4%,65.4%and 4.8%,respectively.For upper third of the rectum:100%of T3 stage patients got no downstaging.For middle rectum:downstaging rate for stage III,T4 and T3 was 55.6%,57.1%and 7.1%,respectively.For lower rectum:downstaging rate for stage III,T4 was 50.0%and 100.0%,respectively.No acute toxicity was seen,86.7%of the patients performed laparoscopic sphincter-preserving surgery.Conclusion:For the treatment of locally advanced rectal cancer,neoadjuvant therapy is standard.Preoperative short-course radiation therapy is a reasonable therapeutic option because it demonstrates benefits in tumour downstaging especially for middle and lower rectum. 展开更多
关键词 Rectal cancer short-course RADIATION THERAPY PREOPERATIVE DOWNSTAGING PELVIC 3D-conformal RADIATION therapy.
在线阅读 下载PDF
Diagnostic Value of 128-slice Spiral CT Combined with Virtual Colonoscopy for Colorectal Cancer 预览
19
作者 Wen-juan TANG Zhuang NIE +3 位作者 Wen-liang FAN Lan CHENG Zi-qiao LEI Ming YANG 《当代医学科学(英文)》 SCIE CAS 2019年第1期146-152,共7页
The objective of this study was to evaluate the diagnostic value of 128-slice spiral CT combined with virtual colonoscopy in diagnosis of colorectal cancer.We retrospectively analyzed 45 patients of colorectal disease... The objective of this study was to evaluate the diagnostic value of 128-slice spiral CT combined with virtual colonoscopy in diagnosis of colorectal cancer.We retrospectively analyzed 45 patients of colorectal diseases who underwent definition AS+128-slice spiral CT combined with virtual colonoscopy after bowel preparation and gas injection to evaluate the clinical diagnostic value of this technology.All the patients received electronic colonoscopy and were confirmed by pathology.In total,colorectal cancer was confirmed in 42 cases and inflammation in 3 cases.Diagnostic results shows:there were 17 cases of lump,10 cases of infiltration,6 cases of ulcer,9 cases of mixed type,4 cases of liver metastases,and 36 cases of lymph node metastasis.There was no significant difference between 128-slice spiral CT combined with virtual colonoscopy and electronic colonoscopy in detection,localization and characterization of colorectal tumors.CT virtual endoscopy has great advantages in observing the invasion around the lesion and the presence or absence of metastasis in distant organs and lymph node metastasis.It is also possible to understand the shape of the lesion in the intestinal lumen and the length of the lesion involving the lumen of the intestine. 展开更多
关键词 128-slice SPIRAL CT VIRTUAL ENDOSCOPY COLORECTAL cancer
在线阅读 下载PDF
中性粒细胞和淋巴细胞VCS参数与NLR对肿瘤患者化疗后细菌感染辅助诊断价值
20
作者 刘乐乐 李华 《中华肿瘤防治杂志》 CAS 北大核心 2019年第3期190-193,共4页
目的化疗是治疗恶性肿瘤的重要方式之一,但化疗药物会抑制骨髓增生,长期治疗后,机体产生免疫抑制很容易感染。肿瘤患者合并病原菌感染是肿瘤患者的死亡原因之一,本研究回顾性分析探讨白细胞计数(white blood cell count,WBC)、中性粒细... 目的化疗是治疗恶性肿瘤的重要方式之一,但化疗药物会抑制骨髓增生,长期治疗后,机体产生免疫抑制很容易感染。肿瘤患者合并病原菌感染是肿瘤患者的死亡原因之一,本研究回顾性分析探讨白细胞计数(white blood cell count,WBC)、中性粒细胞计数(neutrophil count,NC)、淋巴细胞计数、中性粒细胞和淋巴细胞VCS参数以及中性粒细胞和淋巴细胞计数比值(neutrophil and lymphocyte ratio,NLR)等指标对肿瘤患者化疗后发生细菌感染的辅助诊断价值。方法选取2015-03-01-2016-01-01山东大学附属山东省肿瘤医院接受化学治疗的305例肿瘤患者,根据细菌培养结果确诊为局部细菌感染的肿瘤患者190例(肿瘤感染组),未发生细菌感染的115例(肿瘤未感染组),同期健康体检者75名(健康对照组)。应用Beckman Coulter LH750血细胞分析仪进行血细胞分类计数检查,比较各项指标在三组中的差异,并采用受试者工作特征(receiver operating characteristic curve,ROC)曲线分析各项指标及其联合对肿瘤患者细菌感染的辅助诊断价值。结果 WBC、NC、中性粒细胞平均体积(mean neutrophil volume,MNV)、中性粒细胞平均传导值(mean neutrophil conductivity,MNC)、淋巴细胞平均光散射值(mean lymphocyte light scatter,MLS)、NLR在健康对照组、肿瘤未感染组以及肿瘤感染组中差异均有统计学意义,均P<0.05。通过ROC曲线分析各指标的诊断价值,各指标ROC曲线下面积(areas under curves,AUC)WBC为0.631,NC为0.654,MNV为0.639,MNC为0.632,MLS为0.717,NLR为0.708,其中MLS和NLR具有较高的辅助诊断价值。MLS临界值取69.700,灵敏度为73.20%,特异度为61.70%;NLR临界值取5.166,灵敏度为65.80%,特异度为69.60%。结论 MLS和NLR相比于WBC、NC等传统的炎症指标可以更好地辅助诊断肿瘤患者化疗后的细菌感染。 展开更多
关键词 中性粒细胞与淋巴细胞计数比值 VCS参数 肿瘤 感染
上一页 1 2 250 下一页 到第
使用帮助 返回顶部 意见反馈