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Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma 预览
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作者 Yan Cheng Mandy Pereira +10 位作者 Neha P.Raukar John L.Reagan Mathew Quesenberry Laura Goldberg Theodor Borgovan W Curt LaFrance Jr Mark Dooner Maria Deregibus Giovanni Camussi Bharat Ramratnam Peter Quesenberry 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期676-681,共6页
At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential bioma... At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI and evaluation of TBI severity.We hypothesize that the genetic profile of salivary extracellular vesicles in patients with head trauma differs from that in uninjured subjects.Findings from this hypothesis would help investigate the severity of TBI.This study included 19 subjects,consisting of seven healthy controls who denied history of head trauma,six patients diagnosed with concussion injury from an outpatient concussion clinic,and six patients with TBI who received treatment in the emergency department within 24 hours after injury.Real-time PCR analysis of salivary extracellular vesicles in participants was performed using TaqMan Human Inflammation array.Gene expression analysis revealed nine upregulated genes in emergency department patients(LOX5,ANXA3,CASP1,IL2RG,ITGAM,ITGB2,LTA4H,MAPK14,and TNFRSF1A)and 13 upregulated genes in concussion clinic patients compared with healthy participants(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,LTB4R2,LTB4R,PTAFR,CYSLTR1,CES1,KLK1,MC2R,and PTGER3).Each patient group had a unique profile.Comparison between groups showed that 15 inflammation-related genes had significant expression change.Our results indicate that inflammation biomarkers can be used for diagnosis of TBI and evaluation of disease severity.This study was approved by the Institutional Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16). 展开更多
关键词 chronic TRAUMATIC encephalopathy emergency department extracellular vesicles INFLAMMATION OUTPATIENT CONCUSSION clinic real-time PCR analysis SALIVA TRAUMATIC brain injury
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Epidemiological and Clinical Profile of Cervix Cancer at Bamako Radiotherapy Center 预览
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作者 A. Diakité A. S. Koné +8 位作者 Y. L. Diallo K. Diabaté I. M. Diarra M. Ndiaye M. A. Camara M. M. Traoré A. Traoré F. M. Sidibé S. Sidibé 《妇产科期刊(英文)》 2019年第1期92-97,共6页
Cervical cancer remains a major public health problem in Africa, particularly in Mali. The goal of this work was to investigate the epidemiological and clinical aspects of cervix cancer seen at the radiation therapy c... Cervical cancer remains a major public health problem in Africa, particularly in Mali. The goal of this work was to investigate the epidemiological and clinical aspects of cervix cancer seen at the radiation therapy center. This was a descriptive study on the retrospective collection of data on patients found in the Radiation Therapy Centre of Bamako, for invasive cervical cancer be-tween April 2014 and April 2017. The average age of our population was 52 ± 12.5 years with extremes ranges from 18 to 95 years. The most represented age group was [50 - 65 years] with 44.2%. The predominant histological type was squamous carcinoma (CE) with 94.2%. Bleeding were found in almost all patients, most often associated with foul smelling hydrorrhea;80.3% of our patients were stage III and 12.9% of stage IV according to the IFGO classifi-cation. Cervix cancer remains a major public health problem in Mali. The di-agnosis is often late, therefore, resulting in late care and unfavorable progno-sis. Sensitization, vulgarization of vaccination and systematization of screen-ing could be helpful in the fight against this cancer. 展开更多
关键词 EPIDEMIOLOGY CLINIC CERVIX Cancer
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Epidemiological and Clinical Profile of Breast Cancer at Bamako Radiotherapy Center 预览
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作者 A. S. Kone A. Diakite +4 位作者 I. M. Diarra K. Diabate M. A. Camara Y. L. Diallo S. Sidibe 《癌症治疗(英文)》 2019年第9期739-746,共8页
Breast cancer is a major public health problem because of its incidence and mortality. Purpose: To establish the epidemiological and clinical characteristics of breast cancer seen at the radiotherapy center at the Mal... Breast cancer is a major public health problem because of its incidence and mortality. Purpose: To establish the epidemiological and clinical characteristics of breast cancer seen at the radiotherapy center at the Mali Hospital of Bamako. Patients and methods: It was a retrospective, descriptive study of data from patients seen for breast cancer at the Center of Radiotherapy of Mali Hospital between April 2014 and December 2016. The parameters studied were: age, sex, family history of breast cancer, menopausal status, parity, breast tumor location, histological type, histological grade, cancer classification stage. Results: 134 cases of breast cancer were collected, with a frequency of 15%. The sex ratio (H/F) of 0.007. The patient’s mean age was 47 ± 11 years old. The most represented age groups were 33 - 47 years old with 45.5% and 48 - 62 years old with 39%. Three percent (3%) of patients had a family history of breast cancer. Fifty (50%) of the patients were menopausal. The main clinical signs found were : mammary nodules (98%), mastodynia (65%), nodes (67%). Invasive ductal carcinomas were found in 94% of patients, followed by infiltrating lobular carcinomas with 3.7% and metaplastic carcinomas with 1.7%. SBR Grades II and III were mostly found with 37% and 23%. The average tumor size was 87 mm ± 43. Stage III was predominantly represented with 72%, followed by Stage II with 24% and Stages I and IV with 2% each. Conclusion: Breast cancer is common and reaches both before and after 50 years;the diagnosis is usually late;hence it is the importance of raising awareness and screening before the age of 50 and popularizing some complementary tests to better understand the prognosis of this disease and promote more targeted and conservative treatments that will improve survival. 展开更多
关键词 BREAST Cancer EPIDEMIOLOGY CLINIC
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Clinic Evaluation of Heart Failure of Old People in the Department of Internal Medicine of Point G University Hospital from 2008 to 2012 预览
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作者 Assétou Soukho Kaya Abdel Kader Traoré +17 位作者 Djibril Sy Djenebou Traoré Ilo Diall Youssouf Fofana Ibahima Amadou Dembélé Boua Daoud Camara Mamadou Saliou Karim Dao Mamadou Cissoko Kaly Kéï ta Barry Boubacar Sangaré Mamadou Mallé Alassane A. Doumbia Hadiza A. Kaï lou Mamadou Dembélé Hamar Alassane Traoré 《内科学期刊(英文)》 2019年第3期83-88,共6页
Justification: Heart failure (HF) is the evolutionary end of all cardiac diseases. Given the aging population, the rate of incidence is increasing among the elderly. Objectives: The study aims to determine the prevale... Justification: Heart failure (HF) is the evolutionary end of all cardiac diseases. Given the aging population, the rate of incidence is increasing among the elderly. Objectives: The study aims to determine the prevalence of heart failure in the elderly;to describe the clinical aspects;describe etiologies;describe the therapeutic aspects;and describe the evolution of heart failure among the elderly. Method: This was a retrospective study over five years on the operating records of patients hospitalized in the internal medicine department of Hospital Point G. Result: The study included records of 22 elderly patients who were with heart failure of a total of 595 patients hospitalized from 1st January 2008 to 31st December 2012. The prevalence rate was 3.7%, and the average age was 67 ± 7.79 years. The sex ratio was equal to 1. HTA accounted for the cardiovascular risk factors in 77.3%. 72.7% of patients had the symptom of dyspnea and 95.5% of patients had the symptom of IMO. According to the cardiac ultrasound, dilation of the OG represented 68.2% of cases, followed by impaired LVEF (63.6%). The etiologies of IC were represented by dilated cardiomyopathy (95.5%), followed by 13.6% in cardiothyreosis. Drug treatment was dominated by the use of diuretics, ACE inhibitors and sodium diet respectively 95.5%;81.8% and 45.5% of cases. The clinical outcome was favorable in 73%. We recorded four (4) cases of death, which accounted for 18% of patients. 展开更多
关键词 HEART Failure CLINIC ETIOLOGY THERAPEUTICS The ELDER
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Epidemiological, Clinical and Therapeutic Issues of Epulis at Campus University Teaching Hospital of Lom&#233;: About 33 Cases 预览
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作者 Saliou Adam Hamza Dolè +15 位作者 s Sama Palokina Agoda Haré gué na Bissa Winga Foma Essobozou Plaoudé zina Pegbessou Bathoké ou Amana Essoham Boko Eyawè lohn Kpemissi 《口腔学期刊(英文)》 2019年第7期168-174,共7页
Introduction: The epulis is a hyperplastic tumor-like of the gingival or cheek mucosa that would be due to inflammatory reactions. Its pathogenesis remains incompletely understood. It appears to be common in Africa, b... Introduction: The epulis is a hyperplastic tumor-like of the gingival or cheek mucosa that would be due to inflammatory reactions. Its pathogenesis remains incompletely understood. It appears to be common in Africa, but no study has been conducted in Togo. Our purpose was to describe epidemiological, clinical and therapeutic aspects of the epulis at the Campus University Teaching Hospital in Lomé. Patients and methods: This was a retrospective descriptive study on 33 cases at the Odontostomatology Department, from January 1st, 2014 to December 31st, 2016. Results: The prevalence of epulis was 0.88%. The average age of the patients was 36.92 years old. The most affected age group was 20 - 29 years old (30.30%). The sex ratio was 0.57. Low education and poor socio-economic conditions were found to be predisposing factors. Mucous swelling was the main reason for consultation. A local irritative factor was found in more than half of the cases. The preferred seat was gum (63.63%). Inflammatory epulis was found in 36.36% of cases. Biopsy-excision was performed in 96.96% of patients, with a cure without sequelae in 100%. Conclusion: The epulis is a rare benign affection of the gum. Its favoring factors are mechanical or infectious local irritation, or hormonal factors. His diagnosis is essentially clinical, but requires histological confirmation to distinguish it from other serious tumors. Biopsy-excision is the main treatment. No sequelae are observed in all patients of our series. 展开更多
关键词 EPULIS Epidemiology CLINIC Treatment TOGO
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利用加权秩和比法评估兰州市医院血液透析门诊丙型肝炎病毒传播风险 预览
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作者 刘瑞芳 齐跃军 +5 位作者 雷苗 李刚刚 高文龙 李元林 施岱瑜 陈继军 《中国感染控制杂志》 CAS CSCD 北大核心 2019年第11期1014-1019,共6页
目的采用加权秩和比(WRSR)法对兰州市血液透析门诊丙型肝炎病毒(HCV)传播风险进行评估。方法根据WRSR法选取5项指标,利用变异系数确定指标权重,按风险高低划分成高、中、低三个等级,对兰州市17所医院血液透析门诊进行HCV传播风险评估。... 目的采用加权秩和比(WRSR)法对兰州市血液透析门诊丙型肝炎病毒(HCV)传播风险进行评估。方法根据WRSR法选取5项指标,利用变异系数确定指标权重,按风险高低划分成高、中、低三个等级,对兰州市17所医院血液透析门诊进行HCV传播风险评估。结果WRSR值与概率单位存在高度相关性(r=0.981,线性回归方程为:WRSR=0.164×Y-0.311)。分档结果显示Y16和Y17两所医院血液透析门诊感染HCV为低风险,Y1医院血液透析门诊HCV感染有高风险,其他14所医院为中等风险。结论兰州市医院血液透析门诊中HCV传播风险等级差异很大,大部分处于中、低风险水平。血液透析门诊应根据自身薄弱环节采取针对性的措施,加强HCV传播的防控工作。 展开更多
关键词 加权秩和比法 风险评估 血液透析 门诊 丙型肝炎病毒
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基于医护合作的遗传性肠癌门诊的管理
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作者 吴晓丹 姜武 +1 位作者 李原 丁培荣 《中国护理管理》 CSCD 北大核心 2019年第1期16-19,共4页
目的 :构建基于医护合作的遗传性肠癌门诊并评价其实践效果,以规范遗传性肠癌患者的管理、改善其亲属肿瘤防治的效果并推动遗传性肿瘤诊疗及研究的规范化发展。方法 :构建基于医护合作的遗传性肠癌门诊,由经过严格选拔并培训的1名结直... 目的 :构建基于医护合作的遗传性肠癌门诊并评价其实践效果,以规范遗传性肠癌患者的管理、改善其亲属肿瘤防治的效果并推动遗传性肿瘤诊疗及研究的规范化发展。方法 :构建基于医护合作的遗传性肠癌门诊,由经过严格选拔并培训的1名结直肠外科主任医师和1名肿瘤专科护士出诊,规范了出诊医生及护士的资质和培训要求,确立接诊对象为有遗传性肠癌风险的患者及亲属。由护士预约、询问患者家族史并绘制家系图、收集患者及家属的诊治资料,主任医师接受就诊对象的遗传咨询。结果 :经过2年半的实践,共接诊502人次,收集并绘制家系图223个,确诊并随访管理遗传性肠癌家系120个;患者亲属中,检出携带高危风险基因52例,肠镜筛查检出肠癌5例,息肉8例。结论 :遗传性肠癌门诊的设立,使遗传性肠癌患者得以确诊,并提高高危亲属的基因检测及肿瘤筛查率,促进高危人群的早期诊断、早期治疗,为遗传性肿瘤门诊的构建提供了实践依据。 展开更多
关键词 结直肠肿瘤 遗传性 医护合作 门诊 遗传咨询 风险管理
Hepatocellular carcinoma staging systems:Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population 预览
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作者 Laura Bainy Rodrigues de Freitas Larisse Longo +2 位作者 Deivid Santos Ivana Grivicich Mário Reis Alvares-da-Silva 《世界肝病学杂志:英文版(电子版)》 2019年第9期678-688,共11页
BACKGROUND Despite being the world’s most widely used system for staging and therapeutic guidance in hepatocellular carcinoma(HCC)treatment,the Barcelona clinic liver cancer(BCLC)system has limitations,especially reg... BACKGROUND Despite being the world’s most widely used system for staging and therapeutic guidance in hepatocellular carcinoma(HCC)treatment,the Barcelona clinic liver cancer(BCLC)system has limitations,especially regarding intermediate-grade(BCLC-B)tumors.The recently proposed Hong Kong liver cancer(HKLC)staging system appears useful but requires validation in Western populations.AIM To evaluate the agreement between BCLC and HKLC staging on the management of HCC in a Western population,estimating the overall patient survival.METHODS This was a retrospective study of HCC patients treated at a university hospital in southern Brazil between 2011 and 2016.Demographic,clinical,and laboratory data were collected.HCC staging was carried out according to the HKLC and BCLC systems to assess treatment agreement.Overall survival was estimated based on the treatment proposed in each system.RESULTS A total of 519 HCC patients were assessed.Of these,178(34.3%)were HKLC-I;95(18.3%)HKLC-IIA;47(9.1%)HKLC-IIB;29(5.6%)HKLC-IIIA;30(5.8%)HKLCIIIB;75(14.4%)HKLC-IV;and 65(12.5%)HKLC-V.According to the BCLC,25(4.9%)were BCLC-0;246(47.4%)BCLC-A;107(20.6%)BCLC-B;76(14.6%)BCLCC;and 65(12.5%)BCLC-D.The general agreement between the two systems was 80.0%-BCLC-0 and HKLC-I(100%);BCLC-A and HKLC-I/HKLC-II(96.7%);BCLC-B and HKLC-III(46.7%);BCLC-C and HKLC-IV(98.7%);BCLC-D and HKLC-V(41.5%).When sub-classifying BCLC-A,HKLC-IIB,HKLC-IIIA and HKLC-IIIB stages according to the up-to-7 in/out criterion,13.4,66.0,100 and 36.7%,respectively,of the cases were classified as up-to-7 out.CONCLUSION In a Western population,the general agreement between the two systems was 80.0%,although in BCLC-B cases the agreement was low,suggesting that some individuals could be candidates for the curative treatment recommended by the HKLC.The authors suggest that the BCLC system should be routinely employed,although for BCLC-B cases it should be associated with the HKLC system. 展开更多
关键词 BARCELONA CLINIC LIVER CANCER STAGING system Hepatocellular carcinoma Hong Kong LIVER CANCER STAGING system
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论《灵枢·终始》理论在针灸临床处方选穴中的运用
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作者 王海宽 王继红 《广州中医药大学学报》 CAS 2019年第8期1291-1296,共6页
探讨《灵枢·终始》篇中关于寸口人迎脉法的具体运用。主要从以下6个方面进行阐述:①寸口人迎脉的具体位置;②寸口人迎脉法指导辨证分经;③寸口人迎脉法指导临床选穴;④补、泻、导法的临床运用;⑤寸口人迎脉法判断临床疗效;⑥验案... 探讨《灵枢·终始》篇中关于寸口人迎脉法的具体运用。主要从以下6个方面进行阐述:①寸口人迎脉的具体位置;②寸口人迎脉法指导辨证分经;③寸口人迎脉法指导临床选穴;④补、泻、导法的临床运用;⑤寸口人迎脉法判断临床疗效;⑥验案举例。针灸临床治疗疾病时以寸口人迎脉法为指导可以达到取穴少而效专力宏的效果。《灵枢·终始》篇具有重要的临床意义。 展开更多
关键词 灵枢 寸口人迎脉法 针灸 临床 选穴
经颅直流电对痉挛的治疗作用研究进展 预览
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作者 焦睿 陈尚杰 余淑芳 《新医学》 2019年第7期481-484,共4页
痉挛是中枢神经系统损伤后常见的症状,如果不能及时有效治疗会严重影响患者的日常生活能力及预后。目前临床上对痉挛的治疗方法较多,效果不一。经颅直流电是新兴的脑刺激技术的一种,其对痉挛是否有治疗作用目前仍争论不一,该文综述了近... 痉挛是中枢神经系统损伤后常见的症状,如果不能及时有效治疗会严重影响患者的日常生活能力及预后。目前临床上对痉挛的治疗方法较多,效果不一。经颅直流电是新兴的脑刺激技术的一种,其对痉挛是否有治疗作用目前仍争论不一,该文综述了近几年的相关文献,为临床治疗提供指引。 展开更多
关键词 经颅直流电 痉挛 临床
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Application of the painless technique for visual induced abortion in early pregnancy clinic female 预览
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作者 WANG Liqi 《国际英语教育研究:英文版》 2019年第1期37-39,共3页
Objective: This project is to analyze and evaluate the efYect of the painless technique in the visual induced abortion. Methods: 300 pregnant women who needed induced abortion and had no contraindication were selected... Objective: This project is to analyze and evaluate the efYect of the painless technique in the visual induced abortion. Methods: 300 pregnant women who needed induced abortion and had no contraindication were selected as the research objects. Under the condition of the informed consent of the pregnant women, they were divided into two groups according to the different methods of the induced abortion. 150 cases in the observation group were treated with the painless technique for visual abortion, and 150 cases in the control group were treated with the painless technique for the blind curettage. Relevant surgical indicators and complications were compared between the two groups. Results: The operation time, the vaginal bleeding time, the induced abortion syndrome, the uterine aspiration incompleteness, and the postoperative infection in the observation group were significantly lower than those in the control group. The difference between the two groups was significant (P 0.05), with the statistical significance. The incidence of complications in the observation group (8.33%) was significantly lower than that in the control group (37.50%). The difference between the two groups was significant (P 0.05), with the statistical significance. Conclusion: The visual induced abortion with the painless technique is of great value in the outpatient induced abortion, and it is worth adopting and applying. 展开更多
关键词 PAINLESS technique VISUAL induced ABORTION early PREGNANCY CLINIC women APPLICATION
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无创助产技术与传统助产在初产妇自然分娩中的应用效果对照研究 预览
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作者 邱霞 《实用妇科内分泌电子杂志》 2019年第11期8-10,共3页
目的对比分析在临床分娩过程中应用无创助产技术与传统助产技术的效果。方法选取我院2017年01月~2018年06月收治的阴道分娩的初产妇117例进行研究,按照数字表法随机分为对照组、观察组,对照组患者(58例)应用传统助产技术,观察组患者(59... 目的对比分析在临床分娩过程中应用无创助产技术与传统助产技术的效果。方法选取我院2017年01月~2018年06月收治的阴道分娩的初产妇117例进行研究,按照数字表法随机分为对照组、观察组,对照组患者(58例)应用传统助产技术,观察组患者(59例)应用无创助产技术。观察并比较两组患者的临床疼痛程度、临床分娩结局、并发症发生情况以及产后的相关观察指标。结果观察组的下床活动时间(1.28±0.70)d、住院天数(3.03±0.22)d显著低于对照组的下床活动时间(2.71±0.40)d、住院天数(5.90±0.11)d;观察组的舒适度(9.53±0.43)分、0级疼痛率(81.36%)显著高于对照组的舒适度(6.01±0.50)分、0级疼痛率(39.66%),差异具有统计学意义(P<0.05)。结论无创助产技术在临床分娩过程中具有较好的临床应用效果,能够有效改善临床分娩结局,降低相关并发症发生率,提高产妇舒适度。 展开更多
关键词 传统助产 无创助产 临床 应用效果
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红外热成像在腰椎间盘突出症诊断中的应用 预览
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作者 张劢 《中国卫生标准管理》 2019年第1期123-124,共2页
目的探讨红外热成像在门诊腰椎间盘突出症诊断中的应用效果。方法将我院收治的300例疑似腰椎间盘突出症患者作为本次研究的观察对象,对所有患者进行CT/MRI检查均确诊为腰椎间盘突出症,并对所有患者进行红外热成像检测。记录观察红外热... 目的探讨红外热成像在门诊腰椎间盘突出症诊断中的应用效果。方法将我院收治的300例疑似腰椎间盘突出症患者作为本次研究的观察对象,对所有患者进行CT/MRI检查均确诊为腰椎间盘突出症,并对所有患者进行红外热成像检测。记录观察红外热成像表现以及红外热成像与CT/MRI检测符合的阳性率和阴性率。结果患者红外热成像图呈现出显著的不对称性。损伤部位图像色彩不匀,脊柱力线呈现间断且不完整;肢体两侧和臀部呈现明显热度不对称,呈现出局部片状高温或低温;腰骶部菱形窝表现为热度不对称。经红外热成像检测阳性274例,阴性26例,红外热成像检测与CT/MRI检测诊断的符合率为91.3%。结论采用红外热成像对腰椎间盘突出症进行诊断,可有效显示病变位置,其准确率高。 展开更多
关键词 CT MRI 红外热成像 门诊 腰椎间盘突出症 诊断
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Green tea and its active compounds in cancer prevention and treatment 预览
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作者 Yi Lu Lu Xu +1 位作者 Hai-Tao Chen Qing-Hua Yao 《TMR食疗与健康管理》 2019年第2期50-55,共6页
Green tea is now widely considered as anticancer substance or food in global.Catechin,the main anticancer component in green tea,exhites the strong biological activity which not only eliminate free radicals showing an... Green tea is now widely considered as anticancer substance or food in global.Catechin,the main anticancer component in green tea,exhites the strong biological activity which not only eliminate free radicals showing antioxygenic function,but also suppress cell proliferation as well as induce cancer cell apoptosis via blocking corresponding signaling pathway.Furthermore,several studies have demonstrated it could regulate the gut microbiota.It also could regulate gut microbiota.Through these functions,it plays important roles in the occurrence and development of cancer.Here,the anticancer compounds in green tea,the theoretical basis of TCM,the clinic applications,as well as the anticancer mechanism are reviewed. 展开更多
关键词 Green TEA ANTI-CANCER COMPOSITIONS TCM theory CLINIC application ANTICANCER mechanism
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中医药治疗放射性肺纤维化临床研究进展 预览
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作者 董广通 张解玉 侯炜 《中国中医药信息杂志》 CAS CSCD 2019年第4期141-144,共4页
放射性肺损伤是胸部放疗常见并发症之一,早期主要表现为放射性肺炎,后期出现不可逆的放射性肺纤维化,严重降低患者生活质量,甚至引发呼吸衰竭而危及患者生命。同时,放射性肺损伤极大限制了放射剂量,影响疗效,或使治疗被迫中断。中医药... 放射性肺损伤是胸部放疗常见并发症之一,早期主要表现为放射性肺炎,后期出现不可逆的放射性肺纤维化,严重降低患者生活质量,甚至引发呼吸衰竭而危及患者生命。同时,放射性肺损伤极大限制了放射剂量,影响疗效,或使治疗被迫中断。中医药治疗放射性肺纤维化效果确切,可提高患者有效生存期,不良反应小。本文从放射性肺纤维化的病名归属、病因病机及临床治疗研究方面做一综述,为该病临床治疗提供参考。 展开更多
关键词 放射性肺纤维化 中医药 病名 病因 病机 临床 综述
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基于微课的翻转课堂在病理学教学中的应用研究 预览
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作者 梁华 张娇娇 +1 位作者 南鹏飞 宫惠琳 《中国继续医学教育》 2019年第26期13-16,共4页
在当代临床医学建设背景下,国家对医学院校提出了新的教学标准和原理,要求建立“立德树人”“人才化”教学机制。以改革当代医学教学质量,得到国家临床医学专业的认可。医学院校在教学中不断改革教学模式,创新教学体系,为国医学人才开... 在当代临床医学建设背景下,国家对医学院校提出了新的教学标准和原理,要求建立“立德树人”“人才化”教学机制。以改革当代医学教学质量,得到国家临床医学专业的认可。医学院校在教学中不断改革教学模式,创新教学体系,为国医学人才开发建设做出了重要贡献。在微课和翻转课堂建设下,医学核心专业基础课程教学内容和形式都得到了改变。文章结合“微课翻转课堂”教学模式对病理学教学影响,对教学现状、微翻转课堂教学原理、当代医学人才建设要求进行分析,最后总结了微课和翻转课堂运用的教学质量,希望能够探讨改革病理学教学效果的方法。 展开更多
关键词 医学 临床 病理学 微课 翻转课堂 教学现状 教学质量
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食管神经内分泌癌107例的临床及病理特点分析
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作者 孟宇 练延帮 +4 位作者 李珊珊 勾贺 王亚梦 陈洁 宋敏 《中华消化杂志》 CAS CSCD 北大核心 2019年第8期533-538,共6页
目的探讨食管神经内分泌癌(ENEC)患者的临床表现及病理特点。方法纳入2011年1月至2018年11月郑州大学第一附属医院经病理复诊为ENEC的107例患者,分析其临床表现、肿瘤的部位、肿瘤大小、临床病理分型和免疫组织化学标志物情况。计量资... 目的探讨食管神经内分泌癌(ENEC)患者的临床表现及病理特点。方法纳入2011年1月至2018年11月郑州大学第一附属医院经病理复诊为ENEC的107例患者,分析其临床表现、肿瘤的部位、肿瘤大小、临床病理分型和免疫组织化学标志物情况。计量资料采用统计描述,分类资料采用卡方检验。结果107例ENEC患者中,首发症状以进食梗噎最常见,占63.6%(68/107);其次为胸背疼痛,占13.1%(14/107)。60.7%(65/107)的患者经内镜活组织检查确诊,39.3%(42/107)的患者经手术病理确诊。肿瘤位于食管胸上段相对较少,占13.1%(14/107);位于胸中段和胸下段分别占45.8%(49/107)和41.1%(44/107)。肿瘤长径为0.7~9.0 cm,中位数为2.5 cm,其中≤2.5 cm者占57.0%(61/107),>2.5 cm者占43.0%(46/107)。107例患者中,溃疡型50例(46.7%),髓质型32例(29.9%),蕈伞型16例(15.0%),隆起型9例(8.4%)。107例患者中,纯神经内分泌癌(P-NEC) 96例(其中小细胞型95例,大细胞型1例),占89.7%;混合性神经内分泌癌(M-NEC)11例(其中小细胞癌鳞状细胞癌混合型9例,小细胞癌腺癌混合型2例),占10.3%。突触素阳性率为99.0%(104/105),CD56阳性率为98.0%(100/102),嗜铬粒蛋白A(CgA)阳性率为31.5%(17/54),Ki-67为>90%~100%占47.7%(51/107)。肿瘤最大径>2.5 cm的P-NEC占42.1(45/107),M-NEC占0.9%(1/107),P-NEC组的肿瘤最大径大于M-NEC组,差异有统计学意义(χ^2=4.311,P=0.038)。结论ENEC是一种临床表现不特异且有高度侵袭性的恶性肿瘤,确诊主要靠组织病理及免疫组织化学检查。 展开更多
关键词 神经内分泌 食管 免疫组织化学 病理学 临床
映射模式在门诊疾病诊断名称标准化工作中的应用
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作者 曾跃萍 宋菲 +2 位作者 田明月 张欣 刘帅 《中国病案》 2019年第7期4-6,共3页
目的通过门诊疾病诊断名称与就诊原因编码系统的映射和定期维护,实现门诊疾病诊断名称的规范化、统一化和标准化。方法将2015年门诊医生工作站的全部疾病诊断名称导出20余万条,经过去重后逐一筛选,去除不规范及口语化名称,保留相对规范... 目的通过门诊疾病诊断名称与就诊原因编码系统的映射和定期维护,实现门诊疾病诊断名称的规范化、统一化和标准化。方法将2015年门诊医生工作站的全部疾病诊断名称导出20余万条,经过去重后逐一筛选,去除不规范及口语化名称,保留相对规范化的20余万条诊断库名称,与就诊原因编码系统建立映射模式。结果 3万余条不规范诊断疾病名称简写或过于详细情况最多,10 617条,占32%。通过映射工作模式,规范了疾病诊断、缩短了录入时间、保证了数据上传的准确性、为住院疾病诊断名称标准化工作奠定了基础。结论门诊疾病名称的规范化提高了门诊病案数据质量,为处方点评、传染病上报、病例随访等工作提供基础数据支持,提升门诊病历质量监控水平,更大地发挥病案的价值,更好地服务于临床。 展开更多
关键词 疾病诊断 门诊 标准化 映射 病历质量
加强医患沟通在神经疾病临床教学中的应用探索 预览
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作者 赖玉洁 程媛媛 犹秋香 《中国当代医药》 2019年第9期184-186,共3页
近年来,医患矛盾已逐渐成为一个社会问题,我国医患矛盾形势越来越严峻,与社会价值观的扭曲、医疗体制机制不完善有密切的联系,而很大一部分则与人文关怀的缺失、医患沟通不到位有关。良好的医患沟通和交流不仅能提升患者满意度和依从性... 近年来,医患矛盾已逐渐成为一个社会问题,我国医患矛盾形势越来越严峻,与社会价值观的扭曲、医疗体制机制不完善有密切的联系,而很大一部分则与人文关怀的缺失、医患沟通不到位有关。良好的医患沟通和交流不仅能提升患者满意度和依从性,还能有效避免医患纠纷事件发生。提高临床医师与患者及家属的沟通能力对于构建和谐的医患关系及减少不必要的医疗纠纷具有重要的意义。即将踏上工作岗位的临床医师,在大学理论课期间,只学过医患沟通相关理论知识,缺乏基本的医患沟通能力及技巧。本文结合神经疾病科临床实际,从如何培养一个合格的具备良好医患沟通能力的医师出发,提出更合理化的医学教学方法,希望探索出一套对提高神经疾病科临床医师医患沟通能力有帮助的临床教学方法,将医患沟通纳入常规教学,并推广应用。让学生在掌握理论技能的同时,掌握医患沟通的方法,增强实践性,为临床工作的顺利进行提供保障。 展开更多
关键词 神经病学 临床 教学 沟通 探索
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原发CD5阳性弥漫大B细胞淋巴瘤9例临床病理分析 预览
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作者 李青 张云岗 +3 位作者 路军 曹勍 潘静 金木兰 《临床与实验病理学杂志》 CAS CSCD 北大核心 2019年第4期388-392,共5页
目的探讨原发CD5阳性弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)临床病理特征、诊断及鉴别诊断。方法回顾性分析9例DLBCL临床特点、组织学特征及免疫表型,并进行随访。结果8例患者为女性,1例为男性,年龄56~83岁,中位年龄7... 目的探讨原发CD5阳性弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)临床病理特征、诊断及鉴别诊断。方法回顾性分析9例DLBCL临床特点、组织学特征及免疫表型,并进行随访。结果8例患者为女性,1例为男性,年龄56~83岁,中位年龄70岁。9例均有结外累及,包括骨髓、肺及肾上腺、鼻咽部、回盲部、脾脏、乳腺、胸壁。光镜下见中-大异型淋巴样细胞弥漫浸润,核仁显著。免疫表型:9例CD5、CD20、CD79a呈弥漫阳性,8例BCL-2呈阳性,6例BCL-6呈阳性,5例MUM-1呈阳性,4例CD10呈阳性,Ki-67增殖指数40%~80%。Hans分型:6例为生发中心B细胞(germinal center B-cell,GCB)亚型,3例为活化B细胞(activated B-cell,ABC)亚型。随访6.5~23.5个月,1例死亡,6例存活,但病情均进展或复发,2例失访。结论CD5阳性DLBCL患者的病程呈侵袭性,多见于老人,常累及结外。免疫组化标记BCL-2多为阳性,CD10多为阴性。常规化疗效果不佳,预后较差。 展开更多
关键词 弥漫大B细胞淋巴瘤 CD5 临床 病理 免疫组织化学
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