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Constructing Large Scale Cohort for Clinical Study on Heart Failure with Electronic Health Record in Regional Healthcare Platform:Challenges and Strategies in Data Reuse 预览
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作者 Daowen Liu Liqi Lei +1 位作者 Tong Ruan Ping He 《中国医学科学杂志:英文版》 CAS CSCD 2019年第2期90-102,共13页
Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face ... Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform.In this paper,we propose methodology and process on constructing large scale cohorts which forms the basis of causality and comparative effectiveness relationship in epidemiology.We firstly constructed a Chinese terminology knowledge graph to deal with the diversity of vocabularies on regional platform.Secondly,we built special disease case repositories (i.e.,heart failure repository) that utilize the graph to search the related patients and to normalize the data.Based on the requirements of the clinical research which aimed to explore the effectiveness of taking statin on 180-days readmission in patients with heart failure,we built a large-scale retrospective cohort with 29647 cases of heart failure patients from the heart failure repository.After the propensity score matching,the study group (n=6346) and the control group (n=6346) with parallel clinical characteristics were acquired.Logistic regression analysis showed that taking statins had a negative correlation with 180-days readmission in heart failure patients.This paper presents the workflow and application example of big data mining based on regional EHR data. 展开更多
关键词 electronic health RECORDS CLINICAL terminology knowledge graph CLINICAL special disease case REPOSITORY evaluation of data quality large scale COHORT study
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华山医院国家老年疾病临床医学研究中心建设初探
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作者 刘威 陈洁 +3 位作者 李卡 王海鹏 黄蔚 陈靖 《中华医院管理杂志》 CSCD 北大核心 2019年第2期137-140,共4页
随着我国人口老龄化以及老年人群健康保障需求的逐步加大,我国的医疗服务机构面临严峻的挑战。医学知识具有指导临床实践的潜力,但不能直接应用于临床实践,需要在多元化的各类组织之间建立协同研究网络。作者使用主题分析法对阻碍建立... 随着我国人口老龄化以及老年人群健康保障需求的逐步加大,我国的医疗服务机构面临严峻的挑战。医学知识具有指导临床实践的潜力,但不能直接应用于临床实践,需要在多元化的各类组织之间建立协同研究网络。作者使用主题分析法对阻碍建立医学协同机制的因素进行阐述,并归纳和整理了复旦大学附属华山医院国家老年疾病临床医学研究中心探索和建设过程中的经验。针对缺乏对于其他医疗机构提供的临床证据的信任,缺少跨组织的信息共享系统、转诊流程工作规范、医院管理层面的明确要求,缺少完善的补偿分配机制等实践中面临的主要问题,建议医院强化临床医学研究职能,在临床研究生态体系内发挥更加重要的作用。 展开更多
关键词 临床 医学研究 协同机制 价值链
The clinical application of Yanghe Decoction 预览
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作者 Jin-Feng Liu Xiong-Zhi Wu 《TMR药物联合治疗》 2019年第2期75-84,共10页
Yanghe Decoction is a representative prescription of such prescriptions as warming up the yang and dissipating the cold.It has the functions of warming the blood and dispelling cold and stagnation.Yanghe Decoction has... Yanghe Decoction is a representative prescription of such prescriptions as warming up the yang and dissipating the cold.It has the functions of warming the blood and dispelling cold and stagnation.Yanghe Decoction has effects on many diseases.The principle of this kind of disease is blood deficiency and yang,and the clinical manifestation is cold stagnation.Such diseases often occur in multiple systems and in multiple aspects.This article summarizes the compatibility of Yanghe Decoction and its clinical application by reviewing the related literature analysis in recent years,and provides a broad idea for the application of Yanghe Decoction. 展开更多
关键词 Yanghe DECOCTION PRESCRIPTION compatibility CLINICAL APPLICATION
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巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害的疗效分析 预览
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作者 徐森华 毕庆国 +1 位作者 徐成兴 许迎烈 《中南医学科学杂志》 CAS 2019年第3期270-273,共4页
巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害具有一定的优势,对60例脾肾亏虚型遗忘型轻度认知损害患者分为巴戟天颗粒治疗组(观察组)和尼莫地平片治疗组(对照组),比较两组治疗前后中西医疗效及同型半胱氨酸(Hcy)、纤维蛋白原(FIB)水平... 巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害具有一定的优势,对60例脾肾亏虚型遗忘型轻度认知损害患者分为巴戟天颗粒治疗组(观察组)和尼莫地平片治疗组(对照组),比较两组治疗前后中西医疗效及同型半胱氨酸(Hcy)、纤维蛋白原(FIB)水平。其中,观察组总有效率高于对照组,两组患者治疗3个月后Hcy、FIB水平较治疗前均明显降低,且治疗3个月后两组比较,观察组Hcy、FIB水平降低较对照组更明显(P<0.05)。巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害有确切疗效,值得临床推广应用。 展开更多
关键词 巴戟天颗粒 脾肾亏虚型 遗忘型 轻度认知损害 临床
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Relationship between serum homocysteine levels and long-term outcomes in patients with ST-segment elevation myocardial infarction
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作者 Jin Si Xue-Wen Li +6 位作者 Yang Wang Ying-Hua Zhang Qing-Qing Wu Lei-Min Zhang Xue-Bing Zuo Jing Gao Jing Li 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第9期1028-1036,共9页
Background:The mortality of cardiovascular disease is constantly rising,and novel biomarkers help us predict residual risk.This study aimed to evaluate the predictive value of serum homocysteine (HCY) levels on progno... Background:The mortality of cardiovascular disease is constantly rising,and novel biomarkers help us predict residual risk.This study aimed to evaluate the predictive value of serum homocysteine (HCY) levels on prognosis in patients with ST-segment elevation myocardial infarction (STEMI).Methods:The 419 consecutive patients with STEMI,treated at one medical center,from March 2010 to December 2015 were retrospectively investigated.Peripheral blood samples were obtained within 24 h of admission and HCY concentrations were measured using an enzymatic cycling assay.The patients were divided into high HCY level (H-HCY) and low HCY level (L-HCY) groups.Short- and long-term outcomes were compared,as were age-based subgroups (patients aged 60 years and younger vs.those older than 60 years).Statistical analyses were mainly conducted by Student t-test,Chi-squared test,logistic regression,and Cox proportional-hazards regression.Results:The H-HCY group had more males (84.6% vs.75.4%,P=0.018),and a lower prevalence of diabetes (20.2% vs.35.5%,P<0.001),compared with the L-HCY group.During hospitalization,there were seven mortalities in the L-HCY group and 10 in the H-HCY group (3.3% vs.4.8%,P= 0.440).During the median follow-up period of 35.8 (26.9–46.1) months,33 (16.2%) patients in the L-HCY group and 48 (24.2%) in the H-HCY group experienced major adverse cardiovascular and cerebrovascular events (MACCE)(P=0.120).History of hypertension (hazard ratio [HR]:1.881,95% confidence interval [CI]:1.178–3.005,P=0.008) and higher Killip class (HR:1.923,95% CI:1.419–2.607,P<0.001),but not HCY levels (HR:1.007,95% CI:0.987–1.027,P=0.507),were significantly associated with long-term outcomes.However,the subgroup analysis indicated that in older patients,HCY levels were significantly associated with long-term outcomes (HR:1.036,95% CI:1.011–1.062,P=0.005).Conclusion:Serum HCY levels did not independently predict in-hospital or long-term outcomes in patients with STEMI;however,among elderly patients with STEMI,this study reveal 展开更多
关键词 HOMOCYSTEINE Acute ST-SEGMENT ELEVATION myocardial INFARCTION PERCUTANEOUS coronary INTERVENTION Clinical outcome
Clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer
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作者 Zi-Jun Zhao Xiao-Yuan Gu +1 位作者 Wei-Qiang Zhang Li Zhou 《海南医科大学学报(英文版)》 2019年第2期53-56,共4页
Objective:To investigate the clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer.Methods: Ninety-eight patients with non-small cell lung cancer admitted to our hospit... Objective:To investigate the clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer.Methods: Ninety-eight patients with non-small cell lung cancer admitted to our hospital from December 2015 to December 2017 were randomly divided into the control group (49 cases) and the experimental group (49 cases). The group was treated with conventional first-line chemotherapy (pemetrexed plus carboplatin). The experimental group was treated with bevacizumab plus afatinib. The therapeutic effects of the two groups were observed. Immune function, angiogenesis related indicators and incidence of adverse reactions.Results: The levels of CD3+, CD4+, CD4+/CD8+, IgG, IgM, IgA, VEGF, BFGF and HDGF were not significantly different between the two groups. After treatment, both groups were reduced, and the experimental group CD3+, CD4+, The levels of CD4+/CD8+, IgG, IgM and IgA were significantly higher than those of the control group. The levels of VEGF, BFGF and HDGF were significantly lower than those of the control group. The effective rate of the experimental group was significantly higher than that of the control group. There was no significant difference in the rate.Conclusion: Bevacizumab combined with afatinib can effectively improve the therapeutic effect of patients with non-small cell lung cancer. It has been the expression of angiogenic factors, improve the immune function of patients and increase the adverse reactions of patients, which is worthy of clinical promotion. 展开更多
关键词 BEVACIZUMAB AFATINIB NON-SMALL cell LUNG cancer CLINICAL EFFICACY
Respiratory virus infections and inflammatory cytokines in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease
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作者 赵春柳 《中国医学文摘:内科学分册(英文版)》 2019年第1期38-39,共2页
Objective To investigate the characteristics of respiratory viral infections, and correlation between inflammatory cytokines and respiratory virus infections in patients with acute exacerbations of chronic obstructive... Objective To investigate the characteristics of respiratory viral infections, and correlation between inflammatory cytokines and respiratory virus infections in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD). Methods A prospective cohort of patients with acute exacerbations of COPD was enrolled. The sputum of all patients were collected, and 15 respiratory viruses were detected using multi-channel real-time fluorescence quantitative PCR. The clinical characteristics associated with viral infections were analyzed. 展开更多
关键词 COPD SPUTUM CLINICAL
结直肠癌患者瘤组织中EGFR、COX-2表达及其临床意义 预览
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作者 谭志军 蒋宏 《世界最新医学信息文摘(电子版)》 2019年第17期11-12,共2页
目的考察结直肠癌患者瘤组织中EGFR、COX-2表达及其临床意义。方法以2013至2016年在我院接受手术治疗的结直肠癌患者为研究对象,收集患者临床资料,采用免疫组化法分析肿瘤样本中EGFR、COX-2表达水平,卡方检验比较EGFR、COX-2表达与患者... 目的考察结直肠癌患者瘤组织中EGFR、COX-2表达及其临床意义。方法以2013至2016年在我院接受手术治疗的结直肠癌患者为研究对象,收集患者临床资料,采用免疫组化法分析肿瘤样本中EGFR、COX-2表达水平,卡方检验比较EGFR、COX-2表达与患者临床病理特征的关系。结果 EGFR表达与患者瘤径(P<0.05)、N分期显著相关(P<0.05),COX-2表达与患者Dukes分期(P<0.01)、N分期(P<0.05)、肿瘤分级显著相关(P<0.01);EGFR表达与COX-2表达显著相关(P<0.05)。结论肿瘤组织中EGFR和COX-2的表达与结直肠癌瘤组织的病理学特征显著相关,可能与结直肠癌分化和转移有关。 展开更多
关键词 结直肠 肿瘤 临床
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滨州医学院研究生课程临床应用解剖学的改革与实践 预览
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作者 孔凡镇 李京敏 +4 位作者 张力 张璐萍 朱永林 赵冬梅 金昌洙 《中国继续医学教育》 2019年第2期12-13,共2页
分析传统授课过程中存在的问题,遵循以学生为主体的高等教育改革趋势,通过重新构建课程内容、改进课堂理论教学和实验操作训练方法、调整师资配备、改变考核办法等,着力将临床应用解剖学课程建设成为优质课程,达到研究生学习兴趣浓厚、... 分析传统授课过程中存在的问题,遵循以学生为主体的高等教育改革趋势,通过重新构建课程内容、改进课堂理论教学和实验操作训练方法、调整师资配备、改变考核办法等,着力将临床应用解剖学课程建设成为优质课程,达到研究生学习兴趣浓厚、临床技能水平大幅提升的目的。 展开更多
关键词 临床 解剖学 研究生 教学改革
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肝假性淋巴瘤的诊断及治疗 预览
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作者 于宽勇 江春平 《世界华人消化杂志》 CAS 2019年第2期107-111,共5页
假性淋巴瘤又称反应性淋巴组织增生或结节性淋巴组织样增生,可发生于胃肠道,胰腺,眼眶,皮肤等.而肝脏的假性淋巴瘤极少发生,目前文献多为个案报道,对其发病机制、诊断及治疗预后等多方面缺乏系统性认识.肝假性淋巴瘤的临床表现缺乏特异... 假性淋巴瘤又称反应性淋巴组织增生或结节性淋巴组织样增生,可发生于胃肠道,胰腺,眼眶,皮肤等.而肝脏的假性淋巴瘤极少发生,目前文献多为个案报道,对其发病机制、诊断及治疗预后等多方面缺乏系统性认识.肝假性淋巴瘤的临床表现缺乏特异性,影像学检查及肿瘤标志物常无明显特征.该病确诊主要依赖术后病理与免疫组化染色及基因学检查,及时完整的手术切除是目前首选的治疗方法. 展开更多
关键词 肝假性淋巴瘤 病理学 影像 临床 诊断 治疗 预后
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Clinical characteristics of 5375 cases of acute pancreatitis from a single Chinese center, 1996-2015
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作者 Shun-Wei Huang En-Qiang Mao +4 位作者 Hui-Si Wang Bing Zhao Ying Chen Hong-Ping Qu Er-Zhen Chen 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第10期1233-1236,共4页
Acute pancreatitis (AP) remains a common and lifethreatening gastrointestinal emergency, which is usually induced by gallstones, hyperlipidaemia, alcohol abuse, pancreatic carcinoma, and trauma.[1] According to the 20... Acute pancreatitis (AP) remains a common and lifethreatening gastrointestinal emergency, which is usually induced by gallstones, hyperlipidaemia, alcohol abuse, pancreatic carcinoma, and trauma.[1] According to the 2012 Atlanta consensus, AP is divided into three general grades of severity: mild (MAP), moderate (MSAP), and severe (SAP). 展开更多
关键词 CLINICAL characteristics ACUTE PANCREATITIS
共刺激分子B7H3、B7H4在T淋巴母细胞淋巴瘤/白血病中的表达及其临床意义
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作者 张国珍 李静 +3 位作者 白文启 步鹏 王慧文 郗彦凤 《中华病理学杂志》 CAS CSCD 北大核心 2019年第5期352-357,共6页
目的探讨共刺激分子B7H3、B7H4在T淋巴母细胞淋巴瘤/白血病(T-LBL/ALL)中的表达情况,及其与患者临床病理特征及预后的关系。方法应用免疫组织化学法(IHC)检测2001年1月至2017年6月山西省肿瘤医院诊断的100例T-LBL/ALL(实验组)和30例淋... 目的探讨共刺激分子B7H3、B7H4在T淋巴母细胞淋巴瘤/白血病(T-LBL/ALL)中的表达情况,及其与患者临床病理特征及预后的关系。方法应用免疫组织化学法(IHC)检测2001年1月至2017年6月山西省肿瘤医院诊断的100例T-LBL/ALL(实验组)和30例淋巴结反应性增生(LH,对照组)中B7H3与B7H4蛋白表达,应用即时荧光定量聚合酶链反应(real-time RT-PCR)检测50例T-LBL/ALL和30例LH中B7H3 mRNA与B7H4 mRNA的表达。结果(1)男性患者79例,女性患者21例。IHC:T-LBL/ALL组中B7H3、B7H4蛋白阳性率分别为23%(23/100)与54%(54/100)。(2)real-time RT-PCR:T-LBL/ALL组中B7H3 mRNA相对表达是LH组的2.5倍。B7H4 mRNA在T-LBL/ALL组与LH组中表达量均极低。(3)单因素分析:T-LBL/ALL组中B7H3蛋白表达与出现B症状、原发淋巴结内均有相关性(P<0.05)。B7H4蛋白表达与纵隔增宽、骨髓累犯相关(P<0.05)。B7H3蛋白、B7H3 mRNA、B7H4蛋白表达和国际预后指数评分与预后相关(P<0.05),且B7H3和B7H4联合表达与T-LBL/ALL预后相关(P<0.05)。(4)多因素Cox回归分析:B7H3 mRNA表达是影响T-LBL/ALL预后的独立危险因素(P<0.05)。结论B7H3、B7H4表达与T-LBL/ALL临床病理参数及预后密切相关,提示B7H3、B7H4表达在T-LBL/ALL的发展中起着重要作用。 展开更多
关键词 淋巴瘤 白血病 病理学 临床
Traditional Chinese Medicine Syndromes Distribution in Colorectal Cancer and its Association with Western Medicine Treatment and Clinical Laboratory Indicators
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作者 Meng-Die Yang Xiao-Le Chen +11 位作者 Xue-Qing Hu Xiao-Zheng Xie Wen-Jun Zhou Chun-Gen Zhou Bin Jiang Qing Ji Qi Li Peng Wang Zhi-Qiang Meng Wen-Hai Wang Yuan-Jia Hu Shi-Bing Su 《世界中医药杂志:英文版》 2019年第2期81-87,共7页
Objective:The objective of the study is to explore the traditional Chinese medicine (TCM) syndrome distribution in colorectal cancer (CRC) and its correlation with treatment methods and clinical laboratory indicators.... Objective:The objective of the study is to explore the traditional Chinese medicine (TCM) syndrome distribution in colorectal cancer (CRC) and its correlation with treatment methods and clinical laboratory indicators.Materials and Methods: Using the CRC cases report form of TCM,760 CRC patients with TCM four diagnosis information,western medicine treatment information and clinical laboratory indicators were collected,and TCM syndromes distribution in CRC were summarized.The correlation between TCM syndrome type and western medicine treatments,clinical laboratory indicators such as liver and kidney function,immune function,and tumor biomarkers was analyzed. Results:In 760 cases of CRC, Spleen deficiency syndrome (SDS, 25%),liver and kidney Yin deficiency syndrome (LKYDS, 13%), LKYDS-SDS,12%,spleen deficient Qi stagnation syndrome (SDQSS, 10%),and damp heat syndrome (DHS, 9%) were more common TCM syndrome types.LKYDS, SDS,LKYDS-SDS,and SDQSS were significantly distributed under different treatment methods (P < 0.001).There was no statistically significant difference in the distribution of immune fUnction and cytokine among the five TCM syndromes (P > 0.05),but there was statistically significant difference in the distribution of blood routine,liver and kidney function, and tumor biomarkers (P < 0.05). Conclusion: LKYDS,SDS,LKYDS-SDS, SDQSS,and DHS were the first five TCM syndromes in CRC.There were the significant correlations between the distribution of TCM syndrome and the clinical laboratory indicators,and the distribution of TCM syndromes was affected by surgery, radiotherapy,and chemotherapy. 展开更多
关键词 Clinical laboratory INDICATORS COLORECTAL cancer traditional Chinese medicine syndrome DISTRIBUTION treatment methods
未放化疗而长期无瘤生存的原发扁桃体弥漫性大B细胞淋巴瘤的临床和病理学特征
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作者 张晓敬 周小鸽 +2 位作者 位嘉 谢建兰 陈淑媛 《中华病理学杂志》 CAS CSCD 北大核心 2019年第5期358-363,共6页
目的探讨未放化疗而长期无瘤生存原发扁桃体弥漫性大B细胞淋巴瘤(DLBCL)的临床和病理学特征。方法收集首都医科大学附属北京友谊医院病理科2006年4月至2017年7月间,原发扁桃体DLBCL的会诊病例共80例,其中未放化疗而长期无瘤生存者10例... 目的探讨未放化疗而长期无瘤生存原发扁桃体弥漫性大B细胞淋巴瘤(DLBCL)的临床和病理学特征。方法收集首都医科大学附属北京友谊医院病理科2006年4月至2017年7月间,原发扁桃体DLBCL的会诊病例共80例,其中未放化疗而长期无瘤生存者10例为实验组,已治疗患者70例为对照组,对患者的临床资料、病理组织学、免疫组织化学染色及分子生物学检测结果进行回顾性分析。结果患者年龄6~79岁,平均年龄46.5岁,男性37例,女性43例。未放化疗而长期无瘤生存的DLBCL,病变大部分局限在扁桃体,切除活检显示结构仅部分破坏,病变比较新鲜,EB病毒编码的小RNA(EBER)检测和荧光原位杂交(FISH)检测t(14;18)结果均为阴性;基因重排检测为单克隆。未放化疗组在年龄、bcl-2表达、CMYC蛋白表达以及CMYC和bcl-2共表达方面与已治疗组相比,差异具有统计学意义(P<0.05);在性别、部位、分型、临床分期等方面,两者间差异无统计学意义(P>0.05);未放化疗组和已治疗组中位总生存期分别为81及20个月,差异无统计学意义(P>0.05)。在年龄<40岁的患者中,未放化疗组在部位和CMYC蛋白表达方面与已治疗组相比,差异有统计学意义(P<0.05),其他各方面差异均无统计学意义(P>0.05)。结论未放化疗而长期无瘤生存的原发扁桃体DLBCL具有相对独特的临床和病理学特征。生存分析结果显示未放化疗组可长期无瘤生存,可以使患者免受放疗和化疗带来的副作用。 展开更多
关键词 扁桃体肿瘤 淋巴瘤 大B-细胞 弥漫性 病理学 临床
Clinical and Epidemiological Evolution of Sheep Pox in Morocco 预览
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作者 Sara Lafar Khalil Zro +4 位作者 Andy Haegeman Mounir Khayli Kris De Clercq Renaud Lancelot My Mustapha Ennaji 《农业科学与技术:A》 2019年第2期103-113,共11页
Sheep pox is an infectious viral disease that affects specifically sheep and it is caused by the Capripoxvirus genus.The clinical signs include fever,diarrhea,difficulty breathing,nodules,lung lesions and death.In Mor... Sheep pox is an infectious viral disease that affects specifically sheep and it is caused by the Capripoxvirus genus.The clinical signs include fever,diarrhea,difficulty breathing,nodules,lung lesions and death.In Morocco,the 2010 epidemic of sheep pox was characterized by the emergence of a nodular form of the disease.The local strain was isolated and the analysis of affected animals was positively confirmed by virus isolation and real-time polymerase chain reaction(RT-PCR).The epidemiological analysis of 911 data records showed that the virus is endemic in the country;an average of 350 cases per year with an epizootic evolution was observed in 2010.The incidence varies depending on provinces and the disease appears confined to the central and the eastern regions of the country where a very intensive sheep breeding activity is taking place.The statistical analysis showed that there is a positive correlation between the endemicity and the significant factor of the rural market(p=0.006).The annual average morbidity and mortality rates were 2.96%(1.26%to 4.32%)and 0.71%(0.41%to 0.94%),respectively.The clinical findings associated to the epidemiological data analysis confirmed the presence of sheep pox in its nodular form and suggest that new pathogenic strains may have been introduced from Mauritania.The purpose of this work was to provide a better description of the spatiotemporal evolution of sheep pox disease based on some epidemiological indicators and to put forward plausible hypotheses regarding the emergence of the virus in order to implement an adequate control strategy. 展开更多
关键词 SHEEP pox Capripoxvirus EPIDEMIOLOGY CLINICAL SIGNS virus ISOLATION RT-PCR
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牙周内窥镜在临床教学中的应用研究 预览
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作者 王雷 高东辉 王莹 《全科口腔医学电子杂志》 2019年第22期6-7,共2页
通过借助牙周内窥镜的临床带教实习,学生可以更加真实的了解牙周生理病理结构,并直观老师牙周龈下治疗过程。在牙周临床教学中引入内窥镜辅助教学,加深了学生对牙周病学基本知识的理解和应用,培养了学生临床操作的动手能力,使牙周病学... 通过借助牙周内窥镜的临床带教实习,学生可以更加真实的了解牙周生理病理结构,并直观老师牙周龈下治疗过程。在牙周临床教学中引入内窥镜辅助教学,加深了学生对牙周病学基本知识的理解和应用,培养了学生临床操作的动手能力,使牙周病学科的临床教学更生动直观,更具灵活性和吸引力,教学效果更为显著。 展开更多
关键词 牙周内窥镜 教学 临床
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Prospects for immunotherapy as a novel therapeutic strategy against hepatocellular carcinoma 预览
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作者 Yu Akazawa Toshihiro Suzuki +3 位作者 Toshiaki Yoshikawa Shoichi Mizuno Yasunari Nakamoto Tetsuya Nakatsura 《世界荟萃分析杂志》 2019年第3期80-95,共16页
Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, with a poor clinical prognosis. Many standard therapies are often considered for HCC treatment today;however, these conventional therapies often... Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, with a poor clinical prognosis. Many standard therapies are often considered for HCC treatment today;however, these conventional therapies often fail to achieve sufficiently effective clinical results. Today, HCC therapy is set to undergo a major revolution, owing to rapid developments in cancer immunotherapy, particularly immune checkpoint inhibitor therapy. Cancer immunotherapy is a novel and promising treatment strategy that differs significantly from conventional therapies in its approach to achieve antitumor effects. In fact, many cancer immunotherapies have been tested worldwide and shown to be effective against various types of cancer;HCC is no exception to this trend. For example, we identified a specific cancer antigen called glypican-3 (GPC3) and performed clinical trials of GPC3-targeted peptide vaccine immunotherapy in patients with HCC. Here, we present an overview of the immune mechanisms for development and progression of HCC, our GPC3-based immunotherapy, and immune checkpoint inhibitor therapy against HCC. Finally, we discuss the future prospects of cancer immunotherapy against HCC. We believe that this review and discussion of cancer immunotherapy against HCC could stimulate more interest in this promising strategy for cancer therapy and help in its further development. 展开更多
关键词 Hepatocellular carcinoma CANCER IMMUNOTHERAPY Immune CHECKPOINT inhibitor GLYPICAN-3 CANCER vaccine Clinical trials CYTOTOXIC T-LYMPHOCYTES
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多灶性多中心性乳腺癌的临床病理特征分析
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作者 陈香蓉 权毅 《临床外科杂志》 2019年第1期55-58,共4页
目的探讨多灶性多中心性乳腺癌的临床病理特征。方法多灶性多中心性乳腺癌组56例,单一病灶性乳腺癌(对照组) 150例,分析多灶性多中心性乳腺癌的临床病理特征。结果多灶性多中心性乳腺癌组及对照组组织学类型为浸润性小叶癌者分别占8. 9%... 目的探讨多灶性多中心性乳腺癌的临床病理特征。方法多灶性多中心性乳腺癌组56例,单一病灶性乳腺癌(对照组) 150例,分析多灶性多中心性乳腺癌的临床病理特征。结果多灶性多中心性乳腺癌组及对照组组织学类型为浸润性小叶癌者分别占8. 9%、2. 0%,淋巴结转移率分别为69. 6%、51. 3%,淋巴脉管侵犯率分别为为35. 7%、13. 3%,行乳腺癌全乳切除术和保乳术者各占92. 9%、77. 3%和7. 1%、22. 7%,差异均有统计学意义(P <0. 05)。彩超对多灶性多中心性乳腺癌检出敏感性为73. 2%,乳腺钼靶X线摄影检查敏感率为为51. 8%,差异有统计学意义(P <0. 05),两者联合对该类病人检出敏感性为82. 1%。结论和单一病灶性乳腺癌比较,多灶性多中心性乳腺癌淋巴结转移多、淋巴脉管侵犯率高、为浸润性小叶癌的比例高。术前彩超联合钼靶检查能提高多灶性多中心性乳腺癌的诊断率。在切缘阴性的前提下,多灶性乳腺癌可行乳腺癌保乳术。 展开更多
关键词 乳腺癌 多灶性 多中心性 临床 病理
富血小板血浆(PRP)在毛发移植中的临床应用分析 预览
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作者 莫明添 闭陆祥 +1 位作者 邹建红 李兴东 《中国医疗美容》 2019年第7期11-14,共4页
目的探究PRP在毛发移植中的临床运用效果,为发掘PRP技术的功效及临床运用提供参考.方法查找以"PRP""毛发移植"等为关键词的相关研究文献,结合我院实际案例.纳入110例患者,其中52组对照组,58组观察组.对照组单纯使... 目的探究PRP在毛发移植中的临床运用效果,为发掘PRP技术的功效及临床运用提供参考.方法查找以"PRP""毛发移植"等为关键词的相关研究文献,结合我院实际案例.纳入110例患者,其中52组对照组,58组观察组.对照组单纯使用毛发移植术,观察组在对照组的基础上,使用术中注射4MLPRP血浆,术后1个月注射1次,3个月后改为3个月注射1次.对治疗前及治疗后的情况进行评分.结果观察组效果明显,且优于对照组(P<0.05),移植成活率提高8%.PRP可辅助传统的毛发移植术,也可单独地应用于毛发移植中,具有较高的临床应用价值.结论 PRP在毛发移植中具有独特的优势,应增加PRP在毛发移植中的相关研究及临床应用. 展开更多
关键词 PRP 毛发移植 临床应用
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新时代下妇产科临床教学的思考及探讨 预览
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作者 王玎 《中国继续医学教育》 2019年第3期34-36,共3页
妇产科临床教学具有较强的整体性,并且与诸多方面密切相关,由于近些年来生物科学技术的飞速发展,医学知识迅猛增加,医学教育随之发生较大的变化,一直以来以实践性强为特色,对医生的分析临床问题能力培养、完成手术和治疗以及和患者沟通... 妇产科临床教学具有较强的整体性,并且与诸多方面密切相关,由于近些年来生物科学技术的飞速发展,医学知识迅猛增加,医学教育随之发生较大的变化,一直以来以实践性强为特色,对医生的分析临床问题能力培养、完成手术和治疗以及和患者沟通能力的要求都很高。面对如此高的挑战,妇产科教学的难度也随之提高,应该以理论结合实践为基本原则。思维的单一和创新的缺失是在传统教育体系中教育出的学生里普遍存在的问题,教育的创新是对新一代医务工作者摆脱死记硬背的学习方法的根本解决办法,也是当前应解决的关键问题。为此本文特就新时代下妇产科临床教学的思考及探讨展开研究。 展开更多
关键词 新时代 妇产科 临床 教学 思考 探讨
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